CLUSTAL format seed alignment for MF_01470

_____________________________________________________________________________

Features found in the protein:_____________________________________________________________________________

Q3J7J6_NITOC      ------------------------------------------------------------
CAS1_PECAS        ------------------------------------------------------------
Q5NPQ6_ZYMMO      ------------------------------------------------------------
CAS1_PSEAB        ------------------------------------------------------------
E1V4T7_HALED      ------------------------------------------------------------
Q6NEQ3_CORDI      ------------------------------------------------------------
CAS1B_CHLTE       ------------------------------------------------------------
I3Y7Y6_THIV6      ------------------------------------------------------------
CAS1A_RHORT       ------------------------------------------------------------
CAS1C_METHJ       ------------------------------------------------------------
CAS1_ECOLI        ------------------------------------------------------------
CAS1_GEOSL        ------------------------------------------------------------
CAS1B_THET8       ------------------------------------------------------------
C7QEM2_CATAD      ------------------------------------------------------------
F4H8A4_CELFA      ------------------------------------------------------------
CAS1_CLOSS        ------------------------------------------------------------
Q03C58_LACP3      ------------------------------------------------------------
CAS1_STRTR        ------------------------------------------------------------
Q73QW5_TREDE      ------------------------------------------------------------
CAS1_NEIM8        ------------------------------------------------------------
A6GZS0_FLAPJ      ------------------------------------------------------------
CAS1B_METHJ       ------------------------------------------------------------
CAS1_THEPD        ------------------------------------------------------------
CAS1_MYCTU        ------------------------------------------------------------
CAS1_MYCTO        ------------------------------------------------------------
CAS1A_METHJ       ------------------------------------------------------------
Q8PS38_METMA      ------------------------------------------------------------
CAS1B_SACS2       ------------------------------------------------------------
CAS1A_SACS2       ----------------------------------------MVHKVSQREFSRCYKRNCDC
CAS1_KORCO        ------------------------------------------------------------
CAS1_HYPBU        ------------------------------------------------------------
CAS1A_ARCFU       ------------------------------------------------------------
CAS1B_METRM       ------------------------------------------------------------
CAS1C_METRM       ------------------------------------------------------------
Q7MR72_WOLSU      ------------------------------------------------------------
G0GAL1_SPITZ      ------------------------------------------------------------
CAS1A_PYRAE       ------------------------------------------------------------
CAS1B_PYRAE       ------------------------------------------------------------
CAS1A_THEYD       ------------------------------------------------------------
CS4F1_LEPIN       ------------------------------MGIHSLLYCERLFYLEEVEGILVADDRVYA
CS4F1_MYXXD       MSVVVTRYRGGGPQYMNASSTSPKPVVGEPSIRTHALHALAYCERLFYLEEVEELRVADA
CAS1_HALVD        ------------------------------------------------------------
CAS1_NANEQ        ------------------------------------------------------------
CAS1B_THEYD       ------------------------------------------------------------
CAS1_THEMA        ------------------------------------------------------------
CAS1_FUSNN        ------------------------------------------------------------
CAS1_THEKO        ------------------------------------------------------------
CAS1_PYRHO        ------------------------------------------------------------
D5VSN5_METIM      ------------------------------------------------------------
CAS1_METJA        ------------------------------------------------------------
CAS1B_ARCFU       ------------------------------------------------------------
CAS1_METTH        ------------------------------------------------------------
CAS1A_METRM       ------------------------------------------------------------
CAS1_CLOPS        ------------------------------------------------------------
CAS1C_THEYD       ------------------------------------------------------------
CAS1B_MOOTA       ------------------------------------------------------------
CAS1_AQUAE        ------------------------------------------------------------
CAS1_METKA        ------------------------------------------------------------
Q6ZEC7_SYNY3      ------------------------------------------------------------
CAS1A_THET8       ------------------------------------------------------------
CAS1C_RHORT       ------------------------------------------------------------
CAS1D_METHJ       ------------------------------------------------------------
CS4F1_GEOSL       -------------------------MAETDGSIPLIPVRMLNEHVYCPRLAYLMWVQGEF
CS4F1_RHORT       MAPSDTPPSAEDLPSQGELALFAPPATAEDALVPASMVNAWIYCPRLAVLEWGRGEKARS
CAS1C_THET8       ------------------------------------------------------------
CAS1A_MOOTA       ------------------------------------------------------------
CAS1_LEPIN        ------------------------------------------------------------
A6VNV5_ACTSZ      ------------------------------------------------------------
CAS1B_RHORT       ------------------------------------------------------------
Q0AZN9_SYNWW      ------------------------------------------------------------
CAS1A_CHLTE       ------------------------------------------------------------
                                                                              

Q3J7J6_NITOC      ----------------------------MPILPSHRQ-----------------------
CAS1_PECAS        ------------------MDNAFSPSDLKTILHSKRA-----------------------
Q5NPQ6_ZYMMO      -------------------MKPITSGDLKTILHSKRA-----------------------
CAS1_PSEAB        -------------------MDDISPSELKTILHSKRA-----------------------
E1V4T7_HALED      -------------------MDDLSPSDLKTILHSKRA-----------------------
Q6NEQ3_CORDI      ------------MPYSHDAIAFSTIPASHQIRLEDRL-----------------------
CAS1B_CHLTE       ------MKSNTLGDEGNPARLLIKVTRETLPQVKEKY-----------------------
I3Y7Y6_THIV6      ------------------MLKGRLGLETSRMPHADRH-----------------------
CAS1A_RHORT       -------------------MADPAFVPLRPIAIKDRS-----------------------
CAS1C_METHJ       --------------------MTPTLPDIKPIPIKERS-----------------------
CAS1_ECOLI        ----------------------MTWLPLNPIPLKDRV-----------------------
CAS1_GEOSL        --------------------MQPQLPPLKPIPIKDRI-----------------------
CAS1B_THET8       -----------------MPPVSSARNLKELPKFRDGL-----------------------
C7QEM2_CATAD      ---------------MAGPAQRGSSTPYQLPRIADRV-----------------------
F4H8A4_CELFA      ---------------MTKIPGVRPPDLSELTRAQDRI-----------------------
CAS1_CLOSS        -----------------------------MPRISDRV-----------------------
Q03C58_LACP3      -----------------MESGAKKADLTELSRVRERV-----------------------
CAS1_STRTR        --------------------------------MAGWR-----------------------
Q73QW5_TREDE      ---------------------------------MSWR-----------------------
CAS1_NEIM8        ---------------------------------MTWR-----------------------
A6GZS0_FLAPJ      ---------------------------------MIKR-----------------------
CAS1B_METHJ       ------------------------------------------------------------
CAS1_THEPD        -----------------------------------MR-----------------------
CAS1_MYCTU        ----------------------------------MVQ-----------------------
CAS1_MYCTO        ----------------------------------MVQ-----------------------
CAS1A_METHJ       ----------------------------------MNS-----------------------
Q8PS38_METMA      ---------------------------MKLLLLNGHG-----------------------
CAS1B_SACS2       -------------------------------MISVRT-----------------------
CAS1A_SACS2       ICRKPKQRRNVYLNYSLELLITIFKEVIPNLPMDKKI-----------------------
CAS1_KORCO        -----------------------------METTQYGH-----------------------
CAS1_HYPBU        ---------------------------------MPEV-----------------------
CAS1A_ARCFU       -----------------------------------MR-----------------------
CAS1B_METRM       -----------------------------------MK-----------------------
CAS1C_METRM       -----------------------------------MK-----------------------
Q7MR72_WOLSU      ---------------------------------MTKH-----------------------
G0GAL1_SPITZ      -------------------------------MAVLPH-----------------------
CAS1A_PYRAE       -----------------------------------ME-----------------------
CAS1B_PYRAE       -----------------------------------MQ-----------------------
CAS1A_THEYD       ----------------------------------MST-----------------------
CS4F1_LEPIN       GRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRI--------------QKRDGDWIP
CS4F1_MYXXD       AVFAGRRLHVQLQEEGEHVELELASEALGLHGRVDAV--------------KTREGTLVV
CAS1_HALVD        ---------------------------------MTKA-----------------------
CAS1_NANEQ        -----------------------------------MK-----------------------
CAS1B_THEYD       ----------------------------------MKK-----------------------
CAS1_THEMA        -----------------------------------ME-----------------------
CAS1_FUSNN        --------------------------MFCIGGVNMKR-----------------------
CAS1_THEKO        ---------------------------------MRKR-----------------------
CAS1_PYRHO        ---------------------------------MRKK-----------------------
D5VSN5_METIM      ---------------------------------MRKK-----------------------
CAS1_METJA        ---------------------------------MRKK-----------------------
CAS1B_ARCFU       ---------------------------------MRKK-----------------------
CAS1_METTH        ---------------------MNSAGLEQCGMIMTRK-----------------------
CAS1A_METRM       ---------------------------------MSKK-----------------------
CAS1_CLOPS        ----------------------------------MGR-----------------------
CAS1C_THEYD       -----------------------------------MR-----------------------
CAS1B_MOOTA       -----------------------------------MR-----------------------
CAS1_AQUAE        ----------------------------------MGR-----------------------
CAS1_METKA        -------------------------------MGAPND-----------------------
Q6ZEC7_SYNY3      ----------------------------------MTS-----------------------
CAS1A_THET8       -----------------------------------MT-----------------------
CAS1C_RHORT       ------------------MVGSGGTGAPPPRSSPMTT-----------------------
CAS1D_METHJ       -------MNIENEVHIENASESKREPKPPEGLLEDDT-----------------------
CS4F1_GEOSL       SHNEFTVDGVIRHRRVDAGGGVLPSETQEDSRIHARSVSLSSERLGITAKIDLVEGEGAY
CS4F1_RHORT       VDLIAGLRAHQATESGPTPALPDPMVLREDQSLKTRRLSLSSERLGLTAELDLLDVEEGM
CAS1C_THET8       ---------------------------MAEGGGGVGV-----------------------
CAS1A_MOOTA       ------------------------------MHILLNT-----------------------
CAS1_LEPIN        ------------------------------------------------------------
A6VNV5_ACTSZ      ------------------------------MRKLQNT-----------------------
CAS1B_RHORT       ------------------------------MKKLLNT-----------------------
Q0AZN9_SYNWW      ------------------------------MRRLLNT-----------------------
CAS1A_CHLTE       ------------------------------MKKHLNT-----------------------
                                                                              

Q3J7J6_NITOC      ------------------------------------------------------------
CAS1_PECAS        ------------------------------------------------------------
Q5NPQ6_ZYMMO      ------------------------------------------------------------
CAS1_PSEAB        ------------------------------------------------------------
E1V4T7_HALED      ------------------------------------------------------------
Q6NEQ3_CORDI      ------------------------------------------------------------
CAS1B_CHLTE       ------------------------------------------------------------
I3Y7Y6_THIV6      ------------------------------------------------------------
CAS1A_RHORT       ------------------------------------------------------------
CAS1C_METHJ       ------------------------------------------------------------
CAS1_ECOLI        ------------------------------------------------------------
CAS1_GEOSL        ------------------------------------------------------------
CAS1B_THET8       ------------------------------------------------------------
C7QEM2_CATAD      ------------------------------------------------------------
F4H8A4_CELFA      ------------------------------------------------------------
CAS1_CLOSS        ------------------------------------------------------------
Q03C58_LACP3      ------------------------------------------------------------
CAS1_STRTR        ------------------------------------------------------------
Q73QW5_TREDE      ------------------------------------------------------------
CAS1_NEIM8        ------------------------------------------------------------
A6GZS0_FLAPJ      ------------------------------------------------------------
CAS1B_METHJ       ------------------------------------------------------------
CAS1_THEPD        ------------------------------------------------------------
CAS1_MYCTU        ------------------------------------------------------------
CAS1_MYCTO        ------------------------------------------------------------
CAS1A_METHJ       ------------------------------------------------------------
Q8PS38_METMA      ------------------------------------------------------------
CAS1B_SACS2       ------------------------------------------------------------
CAS1A_SACS2       ------------------------------------------------------------
CAS1_KORCO        ------------------------------------------------------------
CAS1_HYPBU        ------------------------------------------------------------
CAS1A_ARCFU       ------------------------------------------------------------
CAS1B_METRM       ------------------------------------------------------------
CAS1C_METRM       ------------------------------------------------------------
Q7MR72_WOLSU      ------------------------------------------------------------
G0GAL1_SPITZ      ------------------------------------------------------------
CAS1A_PYRAE       ------------------------------------------------------------
CAS1B_PYRAE       ------------------------------------------------------------
CAS1A_THEYD       ------------------------------------------------------------
CS4F1_LEPIN       YEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDE
CS4F1_MYXXD       YEHKRGRHAPGGDAPEAWPSDRLQAGAYALLVEERFPGAPVECRVRYHQTDTTVRFPLDA
CAS1_HALVD        ------------------------------------------------------------
CAS1_NANEQ        ------------------------------------------------------------
CAS1B_THEYD       ------------------------------------------------------------
CAS1_THEMA        ------------------------------------------------------------
CAS1_FUSNN        ------------------------------------------------------------
CAS1_THEKO        ------------------------------------------------------------
CAS1_PYRHO        ------------------------------------------------------------
D5VSN5_METIM      ------------------------------------------------------------
CAS1_METJA        ------------------------------------------------------------
CAS1B_ARCFU       ------------------------------------------------------------
CAS1_METTH        ------------------------------------------------------------
CAS1A_METRM       ------------------------------------------------------------
CAS1_CLOPS        ------------------------------------------------------------
CAS1C_THEYD       ------------------------------------------------------------
CAS1B_MOOTA       ------------------------------------------------------------
CAS1_AQUAE        ------------------------------------------------------------
CAS1_METKA        ------------------------------------------------------------
Q6ZEC7_SYNY3      ------------------------------------------------------------
CAS1A_THET8       ------------------------------------------------------------
CAS1C_RHORT       ------------------------------------------------------------
CAS1D_METHJ       ------------------------------------------------------------
CS4F1_GEOSL       VSPVDYKRGKRPHVAGGAYEPERVQLCAQGLLLREHGFASDGGALYFVASRERVPVAFDD
CS4F1_RHORT       VIPVEIKVGKRPSVDEGAYLPERAQVCAQALLLREAGYTCLEGALWFAESRERVTVDLTE
CAS1C_THET8       ------------------------------------------------------------
CAS1A_MOOTA       ------------------------------------------------------------
CAS1_LEPIN        ------------------------------------------------------------
A6VNV5_ACTSZ      ------------------------------------------------------------
CAS1B_RHORT       ------------------------------------------------------------
Q0AZN9_SYNWW      ------------------------------------------------------------
CAS1A_CHLTE       ------------------------------------------------------------
                                                                              

Q3J7J6_NITOC      ------------------------------------------------------------
CAS1_PECAS        ------------------------------------------------------------
Q5NPQ6_ZYMMO      ------------------------------------------------------------
CAS1_PSEAB        ------------------------------------------------------------
E1V4T7_HALED      ------------------------------------------------------------
Q6NEQ3_CORDI      ------------------------------------------------------------
CAS1B_CHLTE       ------------------------------------------------------------
I3Y7Y6_THIV6      ------------------------------------------------------------
CAS1A_RHORT       ------------------------------------------------------------
CAS1C_METHJ       ------------------------------------------------------------
CAS1_ECOLI        ------------------------------------------------------------
CAS1_GEOSL        ------------------------------------------------------------
CAS1B_THET8       ------------------------------------------------------------
C7QEM2_CATAD      ------------------------------------------------------------
F4H8A4_CELFA      ------------------------------------------------------------
CAS1_CLOSS        ------------------------------------------------------------
Q03C58_LACP3      ------------------------------------------------------------
CAS1_STRTR        ------------------------------------------------------------
Q73QW5_TREDE      ------------------------------------------------------------
CAS1_NEIM8        ------------------------------------------------------------
A6GZS0_FLAPJ      ------------------------------------------------------------
CAS1B_METHJ       ------------------------------------------------------------
CAS1_THEPD        ------------------------------------------------------------
CAS1_MYCTU        ------------------------------------------------------------
CAS1_MYCTO        ------------------------------------------------------------
CAS1A_METHJ       ------------------------------------------------------------
Q8PS38_METMA      ------------------------------------------------------------
CAS1B_SACS2       ------------------------------------------------------------
CAS1A_SACS2       ------------------------------------------------------------
CAS1_KORCO        ------------------------------------------------------------
CAS1_HYPBU        ------------------------------------------------------------
CAS1A_ARCFU       ------------------------------------------------------------
CAS1B_METRM       ------------------------------------------------------------
CAS1C_METRM       ------------------------------------------------------------
Q7MR72_WOLSU      ------------------------------------------------------------
G0GAL1_SPITZ      ------------------------------------------------------------
CAS1A_PYRAE       ------------------------------------------------------------
CAS1B_PYRAE       ------------------------------------------------------------
CAS1A_THEYD       ------------------------------------------------------------
CS4F1_LEPIN       ELRSKALKTIDRAKGLSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLF
CS4F1_MYXXD       ALRGAVVAAVARARLLRASRERPPVTQEERKCAKCSLAPVCLPEEERQVVGEERPRLFPE
CAS1_HALVD        ------------------------------------------------------------
CAS1_NANEQ        ------------------------------------------------------------
CAS1B_THEYD       ------------------------------------------------------------
CAS1_THEMA        ------------------------------------------------------------
CAS1_FUSNN        ------------------------------------------------------------
CAS1_THEKO        ------------------------------------------------------------
CAS1_PYRHO        ------------------------------------------------------------
D5VSN5_METIM      ------------------------------------------------------------
CAS1_METJA        ------------------------------------------------------------
CAS1B_ARCFU       ------------------------------------------------------------
CAS1_METTH        ------------------------------------------------------------
CAS1A_METRM       ------------------------------------------------------------
CAS1_CLOPS        ------------------------------------------------------------
CAS1C_THEYD       ------------------------------------------------------------
CAS1B_MOOTA       ------------------------------------------------------------
CAS1_AQUAE        ------------------------------------------------------------
CAS1_METKA        ------------------------------------------------------------
Q6ZEC7_SYNY3      ------------------------------------------------------------
CAS1A_THET8       ------------------------------------------------------------
CAS1C_RHORT       ------------------------------------------------------------
CAS1D_METHJ       ------------------------------------------------------------
CS4F1_GEOSL       ELIGRTLAAIDEMGRTALSGTMPPPLEDSPKCPRCSLVGICLPDEVRFLSHLSVEPRPII
CS4F1_RHORT       ALVTATLVATSDLRLTVASGRLPPPLDHSAKCPRCSLLPICLPDEIAWFRKGSIARTPPP
CAS1C_THET8       ------------------------------------------------------------
CAS1A_MOOTA       ------------------------------------------------------------
CAS1_LEPIN        ------------------------------------------------------------
A6VNV5_ACTSZ      ------------------------------------------------------------
CAS1B_RHORT       ------------------------------------------------------------
Q0AZN9_SYNWW      ------------------------------------------------------------
CAS1A_CHLTE       ------------------------------------------------------------
                                                                              

Q3J7J6_NITOC      --------GLYYLEHCRVMAKDERVVY--ACQEG--------------AFTKFFAIPPAN
CAS1_PECAS        --------NVYYLQHCRILVNGGRVEY--VTEEG-----------NQSLYWNI---PIAN
Q5NPQ6_ZYMMO      --------NIYYLEHCRVLVNGGRVEY--ITDRG-----------NKSLYWNI---PIAN
CAS1_PSEAB        --------NLYYLQHCRVLVNGGRVEY--VTDEG-----------RHSHYWNI---PIAN
E1V4T7_HALED      --------NLYYLQHCRVLVNGGRVEY--VTDEG-----------KQSRYWNI---PIAN
Q6NEQ3_CORDI      --------SFLYLEYCLIRQDRTGVIA--IQNGHNESSDEEEKLEPQILRIQL---PVAS
CAS1B_CHLTE       --------PFLYLEKGRIEIDDSSIKW--IDCDC--------------NVVRL---PVAM
I3Y7Y6_THIV6      --------GLIWFERGELCVIDGCLHF--FQGKD----------SLTPYSVQI---PHQT
CAS1A_RHORT       --------SIVFLQRGQLDVVDGAFVL--IDQEG--------------VRVQI---PVGG
CAS1C_METHJ       --------SVVFLGRGELDVIDGAFVL--VDTNG--------------IRMQI---PVGG
CAS1_ECOLI        --------SMIFLQYGQIDVIDGAFVL--IDKTG--------------IRTHI---PVGS
CAS1_GEOSL        --------SVLYVERGNLDVLDGAFVV--VDKTG--------------VRTHL---PVGG
CAS1B_THET8       --------SYLYVEHAVVEREAGGIGI--YDQEG---------------LTLA---PVAG
C7QEM2_CATAD      --------SFVYLERCTVHRDANAITA--QDADG---------------ITHI---PSAT
F4H8A4_CELFA      --------TFLYLERSVIHRDSNAITA--TDERG---------------TVHI---PAAS
CAS1_CLOSS        --------TYIYVEHSKINRVDGSITV--AESRG---------------IVRI---PASM
Q03C58_LACP3      --------TFLYLEHAKINRQDSAIVV--IDTGG---------------TVAI---PAAL
CAS1_STRTR        --------TVVVNIHSKLSYKNNHLIF--RNSYK---------------TEMI---HLSE
Q73QW5_TREDE      --------TVVISNRAKLDLHLNHLVV--RGEKT----------------QKV---FIEE
CAS1_NEIM8        --------SLLIQNGGKLSLQRRQLLI--QQNGE---------------SHTV---PLED
A6GZS0_FLAPJ      --------TLFFGNPAYLSTKNEQIVI--SYPNK------------EQETKTV---AIED
CAS1B_METHJ       ----------MGGFGAHIKSNRTEITI--QHKGK---------------ITDI---PIKD
CAS1_THEPD        --------LLVLRGVDEVTVSSRSTVV--IKSGN--------------RVFER---ALRD
CAS1_MYCTU        --------LYVSDSVSRISFADGRVIV--WSEEL--------------GESQY---PIET
CAS1_MYCTO        --------LYVSDSVSRISFADGRVIV--WSEEL--------------GESQY---PIET
CAS1A_METHJ       --------VLITGAGYRIRKRGDVLTI--ETGKD---------SDTAEPPRTL---SPLG
Q8PS38_METMA      --------INMHVDGAKLHIKDGRFST--TEEPQ----------------EYVFSPKRID
CAS1B_SACS2       --------LVISEYGAYVYVKKNMLVI--KKGDK---------------KVEI---SPSE
CAS1A_SACS2       --------AFVKDYGAYLKVEKGLITC--KIKNQ--------------VKWSI---APTE
CAS1_KORCO        --------LLIDGFGVSLRKRRGRILI--LSKGE---------------KKEI---PMKS
CAS1_HYPBU        --------LLVATPGTRIYVRRGVVYA--EAPSG---------------EKAV---VTAD
CAS1A_ARCFU       --------LVVDGFGKYLGIENGLIVV--KEKGK--------------ALRKV---RPED
CAS1B_METRM       --------LVVDGFGKSVAKRDNQIVI--KENGK--------------EINYY---LAKD
CAS1C_METRM       --------ILIEGYNKSIHKRDNQILIMEKEG----------------ELEKI---NIKK
Q7MR72_WOLSU      --------LYIDEYGSFVGKTSERLTV--SQGGE--------------LKAEI---PLSR
G0GAL1_SPITZ      --------LIVDEYGAFIGKHSERLVV--TKDKE--------------RLAQV---PLIH
CAS1A_PYRAE       --------VVVKDWGVSLGYSRGALVI--KKRGG---------------VDRI---PLFQ
CAS1B_PYRAE       --------IVVASYGARIRAKKGLLIV--EGREG---------------RREY---PLHQ
CAS1A_THEYD       --------VFIDRKDIEIRVDGNSISF--YAKGK--------------KDGSL---PLSP
CS4F1_LEPIN       PEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETG-----------EKSKSEKI---PIQE
CS4F1_MYXXD       DDVRQV--LHVATPGTRVGRAAEELVV--TPPEG------------EGAPSRQ---PGRM
CAS1_HALVD        --------NHHIFADGELSRKEGTLRI--DTLEG--------------ETKYL---PVES
CAS1_NANEQ        --------TIYILSIGKLYRGKNGLYF--INKDK--------------KKSPI---PLES
CAS1B_THEYD       --------SLYIISDGELKRKDNTLYF--ETSEE---------------RKYI---PVEN
CAS1_THEMA        --------SVYLFSSGTLKRKANTICL--ETESG---------------RKYI---PVEN
CAS1_FUSNN        --------SFFLYSNGTLKRKDNTITF--INEKD--------------EKRDI---PIEM
CAS1_THEKO        --------SLTLFSDGNLFRRENTLYF--ENAQG---------------RKPL---AVEG
CAS1_PYRHO        --------PLTIFSDGTLTRRENTLYF--ESAKG---------------RKPL---AIEG
D5VSN5_METIM      --------SLTLLTDGTLFRKENTIYF--ENKYG---------------KKPL---AIEG
CAS1_METJA        --------SLTLLSDGYLFRKENTIYF--ENARG---------------KKPL---AIEG
CAS1B_ARCFU       --------NYYLVSDGKLRRHENTIYF--ENEDG---------------KRPI---PINS
CAS1_METTH        --------NYYITTDGLLKRNENTLYF--INKDL---------------KRPI---PINK
CAS1A_METRM       --------NYYLLSEGILKRKENTIYF--VNEKG---------------SKPL---PINK
CAS1_CLOPS        --------DYYIFSNGRIKRKENTIYF--EDFEG--------------NKKGL---PIED
CAS1C_THEYD       --------NYYIFSNGRIRRKENTIYI--ENEQG--------------DRKAI---PIED
CAS1B_MOOTA       --------TYYIFSSGRLRRMDNTLAL--ELETE---------------RRVV---PVED
CAS1_AQUAE        --------VYYINSHGTLSRHENTLRF--ENAEV---------------KKDI---PVED
CAS1_METKA        --------TVIFLRRGKIERREDAFRI---------------------GKSKY---SAVR
Q6ZEC7_SYNY3      --------IYLTEPGTKVSYHNQQLQI--KQKSR---------------QVIT---RLAE
CAS1A_THET8       --------LHLTRQGATLRLRQGRLLL--EEEGR--------------EVAGF---PARQ
CAS1C_RHORT       --------LYVTQPGSVVRSEGGSLTV--WVETEADDPGPNDSPVRRKRLASV---EPHR
CAS1D_METHJ       --------IYITTPYGKISLDGGRIQV--KDSDG-------------EIVASF---PLEK
CS4F1_GEOSL       PADGRGLPLYVQSPKAYVRKDGDCLVI--EEERV--------------RVAEA---RLGE
CS4F1_RHORT       PASPALP-LYGQTPGARIGKKDYTLVI--QVEGE--------------ADRSL---ALDE
CAS1C_THET8       --------VYVLENEAYLSKEGGTLKV--SRRAG------------REVLLQK---PLIA
CAS1A_MOOTA       --------LYLMTPRTLVRLDHETVKI--EVEGE--------------LKMQI---PLHH
CAS1_LEPIN        ------------------------------------------------------------
A6VNV5_ACTSZ      --------LYITTQGSYLHKERETLVV--EQDRK--------------KVAQL---PVHS
CAS1B_RHORT       --------VYVTTEGTGLRKDGENLVA--ELDGV--------------QKGRV---PLHM
Q0AZN9_SYNWW      --------LYVTTPDSYLAREGENILI--RLEEK--------------IVFRI---PSHN
CAS1A_CHLTE       --------LFVTTQGSYLSKEGECVLI--SIDRV--------------EKTRI---PLHM
                                                                              

Q3J7J6_NITOC      TNVILLGSGT-SLTQAAARLLASEQVMVAFVGGG-----GSPLFL-----------ASQN
CAS1_PECAS        TSVVMLGTGT-SVTQAAMREFARAGVMIGFCGGG-----GTPLFAANEAEVAVSWLSPQS
Q5NPQ6_ZYMMO      TTTILLGTGT-SITQAAMRELGKAGVLVGFCGGG-----GTPLFSANEQETDVLWFSPQS
CAS1_PSEAB        TTSLLLGTGT-SITQAAMRELARAGVLVGFCGGG-----GTPLFSANEVDVEVSWLTPQS
E1V4T7_HALED      TTSLLLGTGT-SITQAAMRELAKAGVLVGFCGGG-----GTPLFAANEVDVDVAWLTPQS
Q6NEQ3_CORDI      LAVLCLGPGT-SISNAAMTSCTRSGCTVIFTGGG-----GVNAYS-----------HATP
CAS1B_CHLTE       LNCILLGPGT-TVTHEAVKVMAAANCGICWVGDD-----SLMFYA-----------SGQT
I3Y7Y6_THIV6      VSMILLGPGS-TVTHDALRLLARHGTLMAAVGED-----GVRCYT-----------APPL
CAS1A_RHORT       LACLMLEPGT-RITHAAIVLCARVGCLVIWVGER-----GTRLYA-----------AGQP
CAS1C_METHJ       LASLMLEPGS-RVSHAAVSLASKVGCLLVFVGEG-----GVRLYS-----------VGHP
CAS1_ECOLI        VACIMLEPGT-RVSHAAVRLAAQVGTLLVWVGEA-----GVRVYA-----------SGQP
CAS1_GEOSL        VACLMLEPGT-RVSHAAVTLASRIGCLLVWIGEA-----GVRLYA-----------SGQP
CAS1B_THET8       LGVLFLGPGT-RITHAAVRLLAENGCTVAWVGEG-----MARFYA-----------QGLG
C7QEM2_CATAD      IGTLLLGPGT-RITHQAMAVLGDCGANVAWVGEH-----GARFYA-----------AARS
F4H8A4_CELFA      LGALLLGPGT-TASHAAMTLLAESGSTAVWVGER-----GVRYYA-----------HGRS
CAS1_CLOSS        IGILLLGPGT-DISHRAMELLGDSGTSVAWVGEQ-----GVRNYA-----------HGRS
Q03C58_LACP3      ISVLMLGPGV-DVTHRAMELMGDAGMSVVWVGER-----GVRQYA-----------PGRA
CAS1_STRTR        IDILLLETTDIVLTTMLVKRLVDENILVIFCDDK-----RLPTAF----------LTPYY
Q73QW5_TREDE      ISVLIIETTAVSITAALLNELIKQKVKVIFCDEK-----RNPASE----------LIGYY
CAS1_NEIM8        IAVIIIENRETLITAPLLSALAEHGATLLTCDEQ-----FLPCGQ----------WLPYA
A6GZS0_FLAPJ      IGVIVLENQQITITNGLLEKLTNNNVALINCDQQ-----HLPIGL----------LMPL-
CAS1B_METHJ       LSHFLLIGGH-TIQTSTITSLVKEGVFISFCESD-----GEPVGY----------ISPYD
CAS1_THEPD        VDAVLVVGSGIKISSSLPPVLALHGIPLSILAKG-------HVAV----------LLNPV
CAS1_MYCTU        LDGITLFGRP-TMTTPFIVEMLKRERDIQLFTTD-----GHYQGR-----------ISTP
CAS1_MYCTO        LDGITLFGRP-TMTTPFIVEMLKRERDIQLFTTD-----GHYQGR-----------ISTP
CAS1A_METHJ       LDLLAIAGDH-SISTAAVRLVTSHGGAIALMDGL-----GNPFGH----------FLP--
Q8PS38_METMA      IDGIIIYGKSGNLTLEAIRWLIKHNVQVSILDWN-----GKLLTT-----------MLPP
CAS1B_SACS2       VDEILITVSC-SISTSALSLALTHGISVMFLNSR-----ETPWGI----------LLPSI
CAS1A_SACS2       LHSIVVLTNS-SISSEVVKVANEYGIEIVFFNKH------EPYAK----------LIPAK
CAS1_KORCO        VKEVVIIGKA-ALSSELLKALAQSGTDLLIATPT-----GRPVAR----------LIPAK
CAS1_HYPBU        TELVVLATGSVSVSGRALRRLAELGVRLVVLGQR-----GQVVAE----------HRPVD
CAS1A_ARCFU       LKQVLIIGKA-AISSDAIKLLLKNRVDVVFLDFN-----GEILGR-----------LSHP
CAS1B_METRM       ISQILLTGKG-SITFDALTLLAENDVDCVSINWK-----GHVDYR-----------LSAP
CAS1C_METRM       IDDITIIGKG-SITFDALRLISENNVRLMSIDYF-----GKINYT-----------LEYP
Q7MR72_WOLSU      LKSVNILKGGISLSSDIIEACSLRGIKIFFLDFR-----NVAHTA-----------ITST
G0GAL1_SPITZ      LEAVLITGNGVGISSDAVHACTERGIPIHFLTRN-----GTPYAS----------LYSAG
CAS1A_PYRAE       VDRIWILTGGVSISSRLVRALSHHFIDVVFFDAK-----GNPVAR----------LFPPE
CAS1B_PYRAE       VDEVLLLTGGISISTRALRALLRAGAVVAVFDQR-----GEPLGI----------FMKPV
CAS1A_THEYD       LKRVVIVGNV-KIETSVLYKLVNHGITVLFLTGK-----LKYSGI-----------LNGP
CS4F1_LEPIN       IESVNIHGNC-QISSQMIKFLVSEEIPVHWFSGG-----GNYIGG------------INI
CS4F1_MYXXD       VSALIAHGAV-QVSAQALAYCVENDIGVHWFTSG-----GRYLGG------------LGG
CAS1_HALVD        IDALYLHGQI-SFNTRALGLLNKHGVPVHIFGWK-----DYYRGS----------YLPKR
CAS1_NANEQ        IKEIFILNKV-SVTYNALKLLADRNIPIHFFYENTKKGISYYLGS----------FLPRQ
CAS1B_THEYD       TREILIFGEV-SMNKRLLEFLTESEIIIHFFNYY-----GYYIGS----------FYPRE
CAS1_THEMA        VMDIKVFGEV-DLNKRFLEFLSQKRIPIHFFNRE-----GYYVGT----------FYPRE
CAS1_FUSNN        VDDFYVMSEM-NFNTKFINYISQFGIPIHFFNYY-----TFYTGS----------FYPRE
CAS1_THEKO        IYDIYVYGHV-NISSQALHFLAQKGIPVHFFNHY-----GHYDGS----------FYPRE
CAS1_PYRHO        IYDIYIYGHV-NITSQALHYIAQKGILIHFFNHY-----GYYDGT----------FYPRE
D5VSN5_METIM      IYDIYIYGNV-NISSQALHYLAQKGIVVHFFNHY-----GYYDGT----------FYPRE
CAS1_METJA        IYDIYIYGKV-SISSQALHYLAQKGIALHFFNHY-----GYYDGS----------FYPRE
CAS1B_ARCFU       IYAIYALGSL-SITSKAISLLAKEGVCIHFFNRY-----GYYIGS----------FYPRE
CAS1_METTH        IYSIYSYGAL-TISSQALNLLSKEGIPIHFFNRY-----GFYSGS----------FYPRE
CAS1A_METRM       IYSMYAYGQI-TISSQVISLFAKEGIPIHFFNYY-----GYYNGS----------FYPRE
CAS1_CLOPS        IERLHIFGEV-DLNTKFLNYISRYSVLISIYNYY-----GFYSGS----------YYSKK
CAS1C_THEYD       VDTIHIFGEV-DLNTKLLNFICQQGKTVHFYNYY-----GFYSGS----------LMPRE
CAS1B_MOOTA       IDHIYCFSEL-DLNTRLLDFLAQKQICLHFFNYY-----GHYSGS----------FIPRE
CAS1_AQUAE        VEEIFVFAEL-SLNTKLLNFLASKGIPLHFFNYY-----GYYTGT----------FYPRE
CAS1_METKA        TTGIIIAGGA-QITTQAVRLALRNEVPIVYL-GG-----NRILGV----------TVPFS
Q6ZEC7_SYNY3      IDLLVLFPGV-QLTDVAIAVLMDQGIETIFLRRD-----GQFRGR-----------LQGQ
CAS1A_THET8       VRSVALWGNV-RLSTPALVFLLRQGVPVFFYSLE-----GFLHGV----------AGAYP
CAS1C_RHORT       LESLVLLGFT-TITANAMRLCMANKIAVSLLDGG-----GGLAAR-----------VVPP
CAS1D_METHJ       VCTMNVFGSA-SVSTPLLKHCSDKEVVINYFTNF-----GKYFGS----------FVP--
CS4F1_GEOSL       TSQVALFGNA-TLTTAALHECLRREIPVTWLSYG-----GWFMGH-----------TVST
CS4F1_RHORT       ISEVVLAGPV-SLTTPAIHELLRREIPVAWMSSG-----FWFLGS-----------TGGQ
CAS1C_THET8       VEEIVILGNA-VVTPALLKHCAQEGVGIHYLSPT-----GTYYAG-----------LTRT
CAS1A_MOOTA       LGSIVCFGDV-TLTTPLIMRCAEDKRLIVFHDQH-----GRFKAR-----------VEGP
CAS1_LEPIN        ------------------------------------------------------------
A6VNV5_ACTSZ      IGHIFCFGNV-LVSPFLMGFCGENNVNLAFFTEN-----GRFLGR-----------LQGR
CAS1B_RHORT       VGSVVVFGGT-YVSPGLMGACAAHGITIVLLDRV-----GRFQAR-----------VEGP
Q0AZN9_SYNWW      IEAIVYFGYP-GASPSLLGLCAEKGITVSFFSPN-----GRFLAR-----------VEGP
CAS1A_CHLTE       LNGIVCFGQV-SCSPFLLGHCAQLGVAVTFLTEH-----GRFLCQ-----------MQGP
                                                                              

Q3J7J6_NITOC      EYRPTEYCQAWMRLWQDNDQRLKVAKTFQRNRAEFLMQQWPKLAEPKP------------
CAS1_PECAS        EYRPTEYLQDWVSFWFDDEKRLAAAIAFQQVRITQIRQHWLGSRLSRESRFTF-------
Q5NPQ6_ZYMMO      EYRPTEYVQAWVKFWFDDEKRLRAAKALQLARSSRIKEQWLKPSLGKDGFLP--------
CAS1_PSEAB        EYRPTEYLQRWVGFWFDEEKRLVAARHFQRARLERIRHSWLEDRVLRDAGFAV-------
E1V4T7_HALED      EYRPTEYLQYWVRFWFDDEKRLDAARCFQLARLDRIEHLWGESRFQRDTGFTP-------
Q6NEQ3_CORDI      LTSTAKWAIAQACLVSNTEYQKKAALAFYKRQFGGNA-----------------------
CAS1B_CHLTE       PTSNTRNMTHQMKLAANPAKALEVARRLFAYRFPDAN-----------------------
I3Y7Y6_THIV6      MPDRSDIARRQAELWGSPRRRISVARQMYALRLGEVL-----------------------
CAS1A_RHORT       GGARADRLLFQARNALDETARLNVVREMYRRRFDDDP-----------------------
CAS1C_METHJ       GGARSDRLLYQARLALDEVLRLKVVKKMFSLRFGEDF-----------------------
CAS1_ECOLI        GGARSDKLLYQAKLALDEDLRLKVVRKMFELRFGEPA-----------------------
CAS1_GEOSL        GGARADRLLYQAKLALDDSARLKVVRKMYALRFREEP-----------------------
CAS1B_THET8       DTRSAARFYRQARAWADPALHLEVVMRLYRMRFSEPL-----------------------
C7QEM2_CATAD      LNRSSALVEAQATLWANRRTRLDIARAMYRMRF---------------------------
F4H8A4_CELFA      LARSSRLLLAQAELVTNQSSRLRVARQMYAMRF---------------------------
CAS1_CLOSS        LSHTSRFLELQAKLVSNTRSRLQVARKMYQMRF---------------------------
Q03C58_LACP3      LTHSSALLVAQAKLVSNNRLRVGVARQMYQMRF---------------------------
CAS1_STRTR        ARHDSSLQIARQIAWKENVKC-EVWTAIIAQKILNQSYYLGECSFFE-------------
Q73QW5_TREDE      GSHDTSEKIRLQIKWDKNIKQL-VWTEVVTEKIRQQKYLLEKLNLPQASL----------
CAS1_NEIM8        QYHR-QLKILKLQLNISEPLKKQLWQHIVRQKILNQAFVADETGNDL-------------
A6GZS0_FLAPJ      NGHTEQSERFKNQINASVPLKKNLWQQTISAKIMNQAGLLKEKGIPCRK-----------
CAS1B_METHJ       YSLFKEIQNLQ-KTAAPYSYALACANESIKSRILAIEKYAEEIGPEI-------------
CAS1_THEPD        GTKYNNYRALQY--TLPKNKALAIALEYLKSRVRGMASIIRNRGGRLPAL----------
CAS1_MYCTU        DVSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQD------------
CAS1_MYCTO        DVSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQD------------
CAS1A_METHJ       LGRSALIEQYEAQASAPEERRLEIARSICTGALENKRTLLSNLERIRGFD----------
Q8PS38_METMA      ESTNLRTKFAQYHAFEDKEARLEIAKKFIEAKFYKSKAVLDFLSQR--------------
CAS1B_SACS2       VTETVKTKKAQYEAIVV-RKDNRYGEEIISSKIYNQSVHLKYWAR---------------
CAS1A_SACS2       YAGSFKVWLKQLTAW--KRRKVEFAKAFIYGKVHNQWVTLRYYERKYGYNL---------
CAS1_KORCO        AGGTARNRYEQYKSLED-RRGIEIARAVIVGKIRNQASNLSYYSKARRMDEELSSE----
CAS1_HYPBU        RVNRTIEARMEQYRVKATGEALYYAAEMVYAKIVNQAKLLRYLAKSRREPWLRDAGYR--
CAS1A_ARCFU       LIGTAKTRREQYLAYGD-KRGVHLAKEFIKAKMANQMAILTNLAKARKDSNPEVAESLLK
CAS1B_METRM       DRKNAIVKKEQYFALTDSRSG-YLAKAFVRAKIENQKAVLGTLAKSREEKDYIIE-----
CAS1C_METRM       SNENIFLRKQQYKTSEN-HKGLIIAREMIMSKMINQKSTIKTLNKNKKLENVKI---FER
Q7MR72_WOLSU      ANHAVANVRKAQFLTIESNHGREIARTLIVGKLKNQRATLQYFYKYLKNTDKQSKK----
G0GAL1_SPITZ      LTGTVATRRAQLLAYHN-GLGLALVVKIASGKLTNQAAFLKYLAKYRKETDPPTHEALTH
CAS1A_PYRAE       ANGTVTHRRAQYEAYLT-GRGFELAKLVTYGKLINQARALRRLGQWKREHYGA-------
CAS1B_PYRAE       GDATGAKRLCQYAAATD-GRGLQLAKKWVWLKIRGQLENLKRWRRRLGK-----------
CAS1A_THEYD       LHNNGLLRVKQYQKSLS-GFSLKFAKELIKRKIVSQRDFLSEIREIKKALAMQ-------
CS4F1_LEPIN       NPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNE-------
CS4F1_MYXXD       GAGNVHRRLRQFEALRQASVCLGLARRLVAAKLEGQLRFLLRASRGDSESRQV-------
CAS1_HALVD        SQLSGNTVVEQVRAYDNTERRLRIGHRIIEASIHNMRANLQYYSGRRG------------
CAS1_NANEQ        KTKSGLVLVKQVEAYKDIEKRTEIALEIVDAIRYNCIKVLEKYHIDEVK-----------
CAS1B_THEYD       HLNSGYMILKQAEHYLDTGKRLNLAEKFVSGAIENIKKVLIYYHNRGKE-----------
CAS1_THEMA        YLNSGFLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKV---------------
CAS1_FUSNN        MNISGQLLVKQVEHYTNEQKRVEIAREFIEGASFNIYRNLRYYNGRGKD-----------
CAS1_THEKO        SLLSGDLIIKQAKHYLDQEKRLILAKLFVRGSALNMEKNLKRWK----------------
CAS1_PYRHO        TLLSGDLIIRQAEHYLNKEKRLFLAKSFVTGGTKNMERNLKNWGIKAK------------
D5VSN5_METIM      KLISGDLTVKQVEHYLNKEKRLELAKLFVFGAIKNIEHNLVKFKNKYK------------
CAS1_METJA        SLHSGYLVVNQVEHYLDKDKRLELAKLFIIGGIKNMEWNLLKFKNKTK------------
CAS1B_ARCFU       SLVSGEVVLRQAEHHLDSEKRLHLARAFVEGAILNMARVLKK------------------
CAS1_METTH        TLLSGDVIIKQAEHVIDHDKRIELARSFVRGAALNMRRVLSYYGIENG------------
CAS1A_METRM       SLLSGDLLIKQAEHNIDFSKRLKLAKLFVEGAAKNILKVLAYYKIENN------------
CAS1_CLOPS        KNVSGVLLVNQALAYDNYEFRVAIAKTFIDSAMHHILRNLRRYKE---------------
CAS1C_THEYD       RNVSGHIVVKQVEHFLDPERRFYLAYSFVEGAIFHMVRNLREYKN---------------
CAS1B_MOOTA       SQLSGFLLVRQVEHYLDQAKRLELARTFVEGALHNIRRNLEKR-----------------
CAS1_AQUAE        SSVSGHLLIKQVEHYLDAQKRLYLAKSFVIGSILNLEYVYKIS-----------------
CAS1_METKA        ERYA-TLRLKQYEIASQPSARLAFARPLIASSILARAAVLEFLANETGITG---------
Q6ZEC7_SYNY3      FATNPLTRIAQYRV-LDSTFGTALAQRLILGKVTNQRAILQRRHRDTGKKNNA-------
CAS1A_THET8       DPHPAHLRAQFA------AEGLPLARAFVVGKLRSALALLERH-----------------
CAS1C_RHORT       EARSADLRLHQYALHLDPPERLIRARAVVTAKLRNAAAVLRGIRSNQASSAA--------
CAS1D_METHJ       -SRNTIALVRRHQAGITKEKSLAICREIIHAKLQNSCVFLAR------------------
CS4F1_GEOSL       GHRNVETRTYQYQRSFDPETCLNLARRWIVAKIANCRTLLRRNWRGEGDEAKA-------
CS4F1_RHORT       GPRSAAVRTAQYALAGDERRRQAFARDLVSAKIRNGRTLLRRNWRGAEAE----------
CAS1C_THET8       PSKNAPARVAQFKAYLEPTWKLALAQRFVLGKIRNGLVFLRRN-----------------
CAS1A_MOOTA       VSGNVFLRHAQHEALSDSKKTTAIARNIVAGKIRNTRQVVLRGAREADNEDDRKA-----
CAS1_LEPIN        -----MIRKAQFKKSEIEKFRLEIARSIVAGKLQNCRSVLSRTARKSKNESEKQD-----
A6VNV5_ACTSZ      QSGNVLLRRAQYQRSESNP--VSIARNIIAAKIQASKRVLQRQIRNHGDNAE--------
CAS1B_RHORT       VAGNVLLRRAQYKASEAPE---DIVKSLILGKVSNQRAVLLRALRDHGADFPAAEALA--
Q0AZN9_SYNWW      QTGNVLLRRKQYRMADEENQVPVLAKYFIAAKILNSRAVLQRGRRDHPDKVGDS------
CAS1A_CHLTE       VKGNILLRRAQYRMADNYDQTATLARLFVIGKIGNARVTLARALRDHPEKTDGEK-----
                                                                              

Q3J7J6_NITOC      HKASLEKLAERYLADIELAGDN--------GTILAQEAKFAKKLYKFWANCTETE-----
CAS1_PECAS        KSEHLQALLDRYQKGLTDCRTS--------NDVLVQEAMMTKALYRLAANAVSYG-----
Q5NPQ6_ZYMMO      DERRLSALLHQSEHAIERASDI--------ATLLIEEARLTKALFKLASETVGY------
CAS1_PSEAB        DATALAVAVEDSARALEQAPNH--------EHLLTEEARLSKRLFKLAAQATRYG-----
E1V4T7_HALED      SKTELKALLTSSREAIGQAVDT--------TALLTEEARLTKKLFRLASHATDYG-----
Q6NEQ3_CORDI      ----------------ITGGSI--------SVMRGLEGRIMRNTYRENAKKAGI------
CAS1B_CHLTE       ----------------LENKTL--------PQMMGMEGLRVRKLYEEMAVKYKVG-----
I3Y7Y6_THIV6      PHRDL-------------------------DTLRGIEGSRVKATYQLMAQRYGIE-----
CAS1A_RHORT       ----------------PARRSV--------DQLRGMEGVRVREIYRLLAKKYAVD-----
CAS1C_METHJ       ----------------SDAYSV--------EQLRGLEGVRVREGYRKIARDTGVI-----
CAS1_ECOLI        ----------------PARRSV--------EQLRGIEGSRVRATYALLAKQYGVT-----
CAS1_GEOSL        ----------------PERRSV--------EQLRGIEGVRVRKMYELLARQHGVA-----
CAS1B_THET8       ----------------PEGLTL--------EQVRGLEGVRVRNAYARWSRETGVP-----
C7QEM2_CATAD      PDEDPSGFMR--------------------QQLLGMEGRRLKDCYRQQSQRTGVP-----
F4H8A4_CELFA      PGEDTSGLTM--------------------QQLRGREGARVRRTYREQAALHGIA-----
CAS1_CLOSS        PEEDVSSLTM--------------------QQLRAKEGARIRKIYRKMSAEYGVD-----
Q03C58_LACP3      PDDDVSTLSM--------------------QELRGKEGARVRRIYREESRRTGVE-----
CAS1_STRTR        KSQSIMELYHGLER----------------FDPSNREGHSARIYFNTL------------
Q73QW5_TREDE      LAEYITDIDI--------------------NDKTNKEAHAAKAYFAA---LFGAG-----
CAS1_NEIM8        AAKRLRTLASEVRS----------------GDTGNREAQAAALYFQAL------------
A6GZS0_FLAPJ      MELWAKEVTS--------------------GDALNHESRAAVFYWQSL------------
CAS1B_METHJ       LFSGELDILTGYAKELENMVLI--------EELRRIEQLVRDMYYEILGRLISPT-----
CAS1_THEPD        PEPPDPALYEDPARLE--------------SDIRSWEAAASNTLWDEVFKLLDPSAAREL
CAS1_MYCTU        VAESIRTMKHSLAWV-DRSGSL--------AELNGFEGNAAKAYFTALGHLVPQE-----
CAS1_MYCTO        VAESIRTMKHSLAWV-DRSGSL--------AELNGFEGNAAKAYFTALGHLVPQE-----
CAS1A_METHJ       LSREIRLVEDAQDKA-LECQSL--------DSLRGVEGSGAHAYFQGFSLAFDEE-----
Q8PS38_METMA      YPEINFDILDGLTKL-KDVKST--------REILGVEGTLAGKYWIEFSKAVPKE-----
CAS1B_SACS2       VTGTKNDYK---------------------ELLDKDEPAAARVYWQNISQLLPKD-----
CAS1A_SACS2       TSQELDRLAREITFVNTA------------EEVMQKEAEAAKVYWRGVKSLLPKS-----
CAS1_KORCO        LYDAAQQLKREMEELKNEEFPDIDEAR---KRIMARESKCANIYWEKIASIMEE------
CAS1_HYPBU        VEGHADRLRQIIENEEPTTP----------EVIRSIEAQAARDYWDAIAQIAPT------
CAS1A_ARCFU       AKKEIDACLNELDGVEAEMIDKVR------ERLLGIEGKASKHYWDAISLVIPEE-----
CAS1B_METRM       QREKVSEHIGKIEKLSNINSDNIR------NNILGIEGQASHEYWSAFASVLDEK-----
CAS1C_METRM       NINEAIKQIGSLRFGERTDIEKSK------MKMMGIEGSASVDYWLAVNELLPKE-----
Q7MR72_WOLSU      LESAIEKIKETIESLKNIELSNNKHWS---QIIMGKEGGMAAIYFDAIGAELLEE-----
G0GAL1_SPITZ      AIETITTHRRQLSRILERTPSPGDHLTRLRSDIMGEEGRAANAYWEAIAHILPAS-----
CAS1A_PYRAE       LAEAASKIADLAGRI-PSCADV--------QCVLGHEGAAASLYWDAVSKT---------
CAS1B_PYRAE       YGTYAESISKAINALASAATP---------REVMEAEAAAAEAYWAAYREI---------
CAS1A_THEYD       ADRAIEILNKAISNIEVTPISI--------DSLRGIEGAASSIYFITYSKIFPNS-----
CS4F1_LEPIN       TESYLATIRSGLKNI-ESADSP--------SQLLGIEGSSARAYFSGLPALLKNSDP---
CS4F1_MYXXD       LASAVRDLRALLPKC-EEAPSL--------EVLLGLEGAGAARYFGALPYLQGEDVDTR-
CAS1_HALVD        DFDSVVETLRELKTAVSDTQRI--------DELRAVEGDARKRYYDCFDSILEAP-----
CAS1_NANEQ        ELRKIDVWKMFEESLNDWKDAI--------NIIRGIESNIWNLFYQGLDKILKL------
CAS1B_THEYD       LSEIISKIQEIATNI-PDCSTT--------DELMAIEGNIRDYYYQSFDIILDNEH----
CAS1_THEMA        RADSLTRYKKKA----EEASNV--------SELMGIEGNAREEYYSMIDSLVSDER----
CAS1_FUSNN        LKLYMDQIEELRKHL-KEVNNV--------EELMGYEGNIRKIYYEAWNIIVNQE-----
CAS1_THEKO        VADGFSGLLDELFEELESARKI--------TEVMNVEARIRGEYYTRWDNALPEG-----
CAS1_PYRHO        LSDYLDEL--------NDARKI--------TEIMNVEARIRQEYYAKWDENLPEE-----
D5VSN5_METIM      FNNELKRL--------ESVKKI--------TEVMNIEGIVRAKYYSLWDETLKDE-----
CAS1_METJA        FSSYIEEL--------NNCNKI--------TEVMNVEGRVRTEYYRLWDETLPDD-----
CAS1B_ARCFU       AEQDDSDVIASLQHL-SSAKSI--------VELMGAEAAARNAYYTKFDEILKN------
CAS1_METTH        ISDTLMDL--------DSSNSV--------TDVMNVEGRIRSDYYNAIDSILPEG-----
CAS1A_METRM       IKNTLTEL--------NESSKI--------TEVMNVEGRIRAEYYQYFDDILPDE-----
CAS1_CLOPS        KTSEFVKAIENERKIMKEAKTI--------EEVMGAEGRARKKYYESYNAFLKFLKND--
CAS1C_THEYD       TDEFQEKIKKELSNA-VETTKI--------SELMGCEGRARDFYYEAFNTFLKSD-----
CAS1B_MOOTA       EYDDICSKLDEIREGIGKTASI--------EELMSLEAHARKAYYDTWEEITG-------
CAS1_AQUAE        ADTYLNKV--------KETNSI--------PELMSVEAEFRKLCYKKLEEVTG-------
CAS1_METKA        LEDAADEVRSEAERA-LNAGST--------DALRGYEGRAACRYFRALAEVLPD------
Q6ZEC7_SYNY3      LAEAIDLIGAYRLSLRSGLGNSSR------DQLMGIEGICAKHYYQVFQFCLPEG-----
CAS1A_THET8       RLPEAGGVVEALARA-EGASEL--------ERLRGAEGEGSRVYFQGLARLLGP------
CAS1C_RHORT       LASAITQTEASAEAAAAAVSA---------ESLLGIEGNGAHQYFAGLRTAFVGG-----
CAS1D_METHJ       KRVEVPSLLKELRDRSLHAVSV--------DSLRGIEGEAASIYFPMLSSSLPDE-----
CS4F1_GEOSL       PPGLLMSLQDDMRHA-MRAPSL--------EVLLGIEGASAGRYFQHFSRMLRGGDGEGM
CS4F1_RHORT       RQIALDRLARLAERA-TTAETT--------ACLLGIEGEAAAVYFRAFPQLFTQAVTTLP
CAS1C_THET8       GAEGWERLKEALLEA-ERAQDE--------EALRGAEGRAADLYFRAFAELLPEE-----
CAS1A_MOOTA       LQETARELAHGLDAL-SRSPDL--------EQIRGIEGNAARHYFATLDRMVRVNREA--
CAS1_LEPIN        IKEAIGKIEKNISLL-EKAESI--------ESIRGYEGASAKTYFSVFDYCIIQQKED--
A6VNV5_ACTSZ      IQTAVSALNSSLMQL-KKAENL--------ELIRGIEGDAASRYFGVFGQLLKAESG---
CAS1B_RHORT       VKDAIDRMAHILRKVGASAEDA--------DHLRGAEGEAASLYFGVFGQLIRSPDGD--
Q0AZN9_SYNWW      IERSIALLAGSVKKV-FDSENL--------NDIRGLEGDAAQRYFSEVDNLILEQKQD--
CAS1A_CHLTE       LKNAQHVLAGCIRRL-QEATDQ--------ELIRGIEGEAAKAYFSVFDECITADDPA--
                                                      *       :               

Q3J7J6_NITOC      ----NFTRDPGK------RDFNDPFNSYLDHGNY-LVYGIAAAVLWVLGIPHSLPVIH-G
CAS1_PECAS        ----DFTR-AKR------GGGTDLANRFLDHGNY-LAYGLAAVSTWVLGLPHGLAVLH-G
Q5NPQ6_ZYMMO      ---SDFTR-SKR------GTGIDPANRFLDHGNY-LAYGLGATATWVLGIPHGLAILH-G
CAS1_PSEAB        ----EFVR-AKR------GSGGDPANRFLDHGNY-LAYGLAATATWVLGIPHGLAVLH-G
E1V4T7_HALED      ----DFTR-VKR------GQGVDPANRFLDHGNY-LAYGLAATATWVLGIPHGLAVLH-G
Q6NEQ3_CORDI      ---RGFKR-DTK--------AADPVNVGLNISNS-ILYGAAATVCTAIGVNPALGIIHRG
CAS1B_CHLTE       ---WKGRR-FEP----GKFEMSDTTNKILTASNA-ALYSIILSAVHSMGYSPHIGFIHSG
I3Y7Y6_THIV6      ---WKGRH-YDR----ANPNATDIPNQAINHAAT-AVQAAAAIAVQAVAAIPQLGFIHED
CAS1A_RHORT       ---WNARR-YDH----NDWDGADIPNRCLSAATA-CLYGLCEAAILAAGYAPAIGFLHRG
CAS1C_METHJ       ---WNGRR-YDP----HSWGSADLPNRCLSAATA-SLYGICEAAVLAAGYSPSIGFLHTG
CAS1_ECOLI        ---WNGRR-YDP----KDWEKGDTINQCISAATS-CLYGVTEAAILAAGYAPAIGFVHTG
CAS1_GEOSL        ---WKARN-YDH----TQWESGDVPNRCLSSATA-CLYGICEAAILAAGYAPAVGFIHTG
CAS1B_THET8       ---WYGRS-YDR----GNWRAADPVNRALSAGAS-YLYGLAHAAIVSLGFSPALGFIHTG
C7QEM2_CATAD      ---WHGRQ-YTP----GNFNAGDAINQAITAAAQ-CMYGVAHTIITALGCSPGLGFIHSG
F4H8A4_CELFA      ---WEKRR-YDP----DDFTSGDPVNQALSAATT-ALYGIVHAVVVALGCSPGLGFVHTG
CAS1_CLOSS        ---WNGRT-YDP----DDFEGGDPVNQALSAANV-ALYGLAYSAIAAMGLATGLGFVHTG
Q03C58_LACP3      ---WTHRE-YDP----ENYQSGSIINQALTAAHA-ALYGLSYSVIVALGASPGLGFVHTG
CAS1_STRTR        -----FGNDFTR-------ESDNDINAALDYGYT-LLLSMFAREVVVCGCMTQIGLKHAN
Q73QW5_TREDE      ---FS-------------RSLDIPINAALNYGYS-ILLSAFNREIIANGYITQLGIFHDN
CAS1_NEIM8        -----FGE-KFT------RNDNNAVNAALNYTYA-VLRAAVARTLTLYGWLPALGLFHRS
A6GZS0_FLAPJ      ---ITVPN-FTR------GQKGIPPNNLLNYGYA-ILRAITARAIVSSGMLPTLGIFHRN
CAS1B_METHJ       ---YLFKR-RTS------RPYLDPVNAIFSFGYG-MLSSACTRAVIGGHLDPGHGYLNR-
CAS1_THEPD        RERYGFAG-RKP-------GHPDPLNKAISAMYA-VLYTLSTKALVAAGLDPTYGFLHRT
CAS1_MYCTU        ---FAFQG-RST------RPPLDAFNSMVSLGYS-LLYKNIIGAIERHSLNAYIGFLHQD
CAS1_MYCTO        ---FAFQG-RST------RPPLDAFNSMVSLGYS-LLYKNIIGAIERHSLNAYIGFLHQD
CAS1A_METHJ       ---WGFLG-RSQ------NPATDPVNSLLSYGYG-MLYIQARQALVLSGYSPYYGAYHET
Q8PS38_METMA      ---YDFCN-RID-QFRRAMGSGDMINTMLNYGYS-LLEAECLKAINSVGLDTHVGFLHEM
CAS1B_SACS2       ---IGFDG-RDV-------DGTDQFNMALNYSYA-ILYNTIFKYLVIAGLDPYLGFIHKD
CAS1A_SACS2       ---LGFKG-RMK----RVSDNLDPFNRALNIGYG-MLRKVVWGAVISVGLNPYIGFLHKF
CAS1_KORCO        ---WKFRG-REK-RTDLEGNVIDPVNLCLNVCYN-LLSAQIWKNVLRFGLDPFLGYLHVE
CAS1_HYPBU        ----PFPG-RQP------RG-EDHLNMALSYGYA-ILYSIAHDALTVAGLDPYAGFLHAD
CAS1A_ARCFU       ---YRFNG-RRGIEIGSPRYAKDIVNAMLNYGYS-ILLAECVKAVELAGLDPYAGFLHVD
CAS1B_METRM       ---WEFFG-RSG------RGAKDPVNSLLNYGYA-VIESEIWKSIYLAGLDPYCGFLHSE
CAS1C_METRM       ---IGFFS-RNN------RHPNDITNASLNYAYA-ILASEVNKALVINGLDSYCGFLHFD
Q7MR72_WOLSU      ---CDFTT-RIG------RGAEDIMNSALNYGYA-ILTSFVWQSIINAGLEAYAGVLHTN
G0GAL1_SPITZ      ---LGFPG-RVR------RGARDPLNSALNYGYA-ILYGEAERALLLAGLDPYAGFLHAD
CAS1A_PYRAE       ---TGLPG-RNP-------EAADPLNLALNYGYG-VLKYAVWRQAVIHGLDPYAGYIHAD
CAS1B_PYRAE       ---TGFPG-RDQ-------EGRDPVNAGLNYGYG-ILKALCFKSILLAGLDPYVGFLHAD
CAS1A_THEYD       ---LKFVR-RIK------RPPKDPVNAMLSLCYT-LLHYEIVREIQLIGLDPTIGFYHQF
CS4F1_LEPIN       ---FLVPNGRSK------RPPKDPFNATLSFLYS-LLYKSVRQAIIAVGLDPSFGFYHTP
CS4F1_MYXXD       ---LRFEG-RNR------RPPRDRFNAVLGFLFG-LVHREVEAAIRAVGLDVAFGFYHQP
CAS1_HALVD        ---FRLAK-REY------NPPSNETNALISFLNG-MVYTSCVSAIRKTALDPTVGFVHEP
CAS1_NANEQ        ---YKLER-RTR------RPPKNEANTIVSFANT-LLYGVTLTEIYKTHLDPTISFLHEL
CAS1B_THEYD       ---FIFET-RTK------RPPKNRINALISFANS-LVYTTCLSEIYQTHLDPRIGYLHAT
CAS1_THEMA        ---FRIEK-RTR------RPPKNFANTLISFGNS-LLYTTVLSLIYQTHLDPRIGYLHET
CAS1_FUSNN        ---IDFEK-RVK------NPPDNMINSLISFVNT-LFYTKVLGEIYKTQLNPTVSYLHQP
CAS1_THEKO        ---FKIVK-RTR------RPPENEMNALISFLNS-RLYATIVSELYNTQLAPTVSYLHEP
CAS1_PYRHO        ---FKIVK-RTR------RPPKNEMNALISFLNS-RLYATIITEIYNTQLAPTISYLHEP
D5VSN5_METIM      ---FKIVK-RTR------KPPKNEMNALISFLNS-RLYATIISEIYNTQLNPSVSYLHEV
CAS1_METJA        ---FKIVK-RTR------RPPKNEMNALISFLNS-RLYPAIITELYNTQLTPTVSYLHEP
CAS1B_ARCFU       ---FEFGK-RSR------MPPENEVNAMISFGNS-LLYSAVLSEIYHTQLNPAISYLHEP
CAS1_METTH        ---FRIGK-RTR------RPPENMTNAMISFGNS-LLYSTVITELYNTQLNPTISYLHEP
CAS1A_METRM       ---FKMEG-RSR------QPPTNMINSLISFGNS-MMYASVITELYNTQLNPTISYLHEP
CAS1_CLOPS        ---FHFNK-REK------KPPNDPINALISFGNS-MMYTTVLGEIYKTQLDPTISYLHEP
CAS1C_THEYD       ---FSMGK-REK------RPPRNPINALISFANS-MIYTTVLNEIYHTQLNPTVSYLHEP
CAS1B_MOOTA       ---WEFGS-RSK------RPPANALNALISFGNA-MMYTVVLKEIYRTALNPTISYLHEP
CAS1_AQUAE        ---WELEK-RTK------RPPQNPLNALISFGNS-LTYAKVLGEIYKTQLNPTVSYLHEP
CAS1_METKA        ---WAFSGRRTR------RPPRDPFNAAISFGYAGVLLPVLLSRTVAAGLEPFLGFLHGP
Q6ZEC7_SYNY3      ---WSFTG-RNR------RPPKDPVNALLSWGYG-VLLARVFSAIVQAGLDPYLGFFHAT
CAS1A_THET8       ---YGFGG-RTR------RPPRDPVNAALSYGYA-LLLGRVLVAVRLAGLHPEVGFLHAE
CAS1C_RHORT       ---IPFLG-RAQ------RPPPDPANSLLSFGYV-LLGNRLTGLLEARGVDPCLGFFHDL
CAS1D_METHJ       ---WRSDK-RTR------RPPRDELNALLSLTYT-MVNTEVISALRQYNLDPFIGVMHVD
CS4F1_GEOSL       G--FDFTT-RNR------RPPKDPVNALLSFAYA-MLTREWTVALAAVGLDPYRGFYHQP
CS4F1_RHORT       A--FAFER-RNR------RPPADPVNACLSLCYA-VLTRTLSSALSIAGLDPWKGFYHTE
CAS1C_THET8       ---FAFGE-RSR------RPPRDPANSLLSLAYT-LLAKECESALLVAGLDPYVGYLHEV
CAS1A_MOOTA       ---FKITH-RNR------RPPLDRMNALLSYIYA-LLLNDCLSAAEGVGLDPQIGYLHVL
CAS1_LEPIN        ---FQFHK-RTR------RPPRSRTNALLSFLYS-LLTNDCIAVCQAVGLDPYIGFLHDE
A6VNV5_ACTSZ      ---FVFDG-RNR------RPPRDGVNALLSFLYS-ILGKDISGALQGVGLDPQVGFLHAD
CAS1B_RHORT       ---FAFRG-RSR------RPPLDPTNALLSFLYT-LLTHDCRSACESVGLDPAVGFLHRD
Q0AZN9_SYNWW      ---FFMAA-RSR------RPPLDNVNALLSFFYT-LLVHECRAALESVGLDPAVGFLHRD
CAS1A_CHLTE       ---FRFEG-RSR------RPPLDRVNCLLSFVYT-LMTHDIRSALESCGLDPAAGFLHKD
                                           *  .                            :  

Q3J7J6_NITOC      TTRRGALVFDVADIIKDTCVMPIAFQHAAAGRS-DQEM-------RQACIAWLDESHAMT
CAS1_PECAS        KTRRGGLVFDVADLIKDALVLPQAFIAAMEGE--DEQE--F----RQRCLTAFQQSEALD
Q5NPQ6_ZYMMO      KTRRGGLVFDVADLVKDATILPQAFLSAMAGD--EESS--F----RQKSIAALTHSESLD
CAS1_PSEAB        KTRRGGLVFDVADLIKDSLILPQAFLSAMRGD--EEQD--F----RQACLDNLSRAQALD
E1V4T7_HALED      KTRRGGLVFDVADLVKDAIILPQAFLSAMKGD--EEQE--F----RQACIERLTRTESLD
Q6NEQ3_CORDI      DTR--SLLFDLADLYKASIVIPLVFSHA------KDED--PVTNIRRHLRREIHSRKIMA
CAS1B_CHLTE       SP--LPFIYDLADLYKQQVSIDLAFSLTADMAGYYDRH--------------KIASEFRK
I3Y7Y6_THIV6      SGQ--SFILDIADLFREAITLKIAFTVAKKAET-DTQT--IDRLVRREAATVFRKQDVIP
CAS1A_RHORT       KPQ--SFVYDVADLYKVETVVPTAFSIAAKIAAGKGDDSPPERQVRIACRDQFRKSGLLE
CAS1C_METHJ       KP--LSFVYDIADLFKFETVVPAAFKTAALNPREPERE--V----RYACRDLFRETQLLK
CAS1_ECOLI        KP--LSFVYDIADIIKFDTVVPKAFEIARRNPGEPDRE--V----RLACRDIFRSSKTLA
CAS1_GEOSL        KPQ--SFVYDIADIFKFETVVPVAFRIAAKKPRDPERE--V----RLACRDAFRQSKILH
CAS1B_THET8       KL--LSFVYDIADLYKADYLVPAAFRTVAESEEAVERR--VRRALREAIQEGRLLERMAE
C7QEM2_CATAD      HE--LSFVMDIADLYKTEIGIPVAFDTAAE----DSTD--IGPRTRRALREQIRTTRLLE
F4H8A4_CELFA      HVR--SFVFDIADLYKADYAIPCAFETAAA----GYSD--IGAETRRAMRDRFRDGHLLE
CAS1_CLOSS        HD--LSFVYDIADLYKADITVPVAFEIASEYE--EGDN--VGKISRQKVRDKFIGGKLFA
Q03C58_LACP3      HD--LSFVYDFADLYKAEVTIPIAFTVAANAT--EQDD--IGQLTRLAVRDAFVDGKLMI
CAS1_STRTR        QFNQFNLASDIMEPFRP-IIDRIVYQ-------------------NRHNNFVKIKKELFS
Q73QW5_TREDE      MFNPFNLGSDLMEPFRP-LVDAEVFKL-------NPQK--F----EHEEKLKIVSVINKK
CAS1_NEIM8        ELNPFNLADDFIEPLRP-LADLTVIHLYEQGRLKAELTPGIKQHLIKTLHYQISIERQHF
A6GZS0_FLAPJ      KYNAYCLADDIMEPYRP-YVDLIVCHIID-----TEDS--YD----------ELTIEIKK
CAS1B_METHJ       --GNQALVQDLMNCWKPKMIDNHAIGFLRSGRL-HQNG--YE---RTKDRC-ILHDEVIE
CAS1_THEPD        QYSVP-LAFDYAEAFKPLAVE-AALDLVNEEGL------------PTLSEDGDLDKDSLN
CAS1_MYCTU        SRGHATLASDLMEVWRAPIIDDTVLRLIADGVV-DTRA--FSK--NSDTGAVFATREATR
CAS1_MYCTO        SRGHATLASDLMEVWRAPIIDDTVLRLIADGVV-DTRA--FSK--NSDTGAVFATREATR
CAS1A_METHJ       YKKQEALVYDLVEEFRQPVVDRTVVTFLAKHMA-TPDD--FT---YPDEGGCMIGTMAKK
Q8PS38_METMA      APSKNSLAYDLQEPFR-FIVDLAVISLIESGAM-ESKD--FI---RTENYNLRLKPTGAR
CAS1B_SACS2       RPGNESLVYDFSEMFKP-YIDFLLVRALRSG---------F----RLKVKGGLIEENSRG
CAS1A_SACS2       RSGRISLVFDLMEEFRSPFVDRKLIGLARESAD-KVTD--------------------LK
CAS1_KORCO        RPGRISLVYDLMEPFRP-MVDRFVFSYLRGM---SPSL--F----SSNIVSGTIASLRSR
CAS1_HYPBU        RSGRPSLTYDYADTYKPIAVDKPLLTAP------RKTD-------CLDTYMGALTYNARR
CAS1A_ARCFU       VSGRSSLAIDLMENFRQQVVDRVVLRLISYRQI-KPED---C---EKRNMVCQLSDNARR
CAS1B_METRM       RYGRASLVYDLIEEFRQQIVDKTVLSIVNRNQI-TPDD--F----EEDGNYIKIHERARR
CAS1C_METRM       RQKRTSLTFDLMEEFRQQLVDKVVFSLVNTKQI-SNDD--------LDKRNNSISLDVRK
Q7MR72_WOLSU      RPGKPSLVLDVMEEYRAWVVDRNIIKLR-----------------SSLAGKKELDAELKK
G0GAL1_SPITZ      RPGKPAMVLDFVEEFRTPVVDRTIIGLATKGVSFDQEE------------DGLLARETRL
CAS1A_PYRAE       KSGRPSLVLDLMEEFRP-HVDLLVIRLRPSADW---------------ADGGVLKREIRA
CAS1B_PYRAE       KSGRPSLVLDFMEQWRPR-VDAVVAQLAE----------------ELEAENGLLTHKSRL
CAS1A_THEYD       EYGRESLACDLVELFR-VNVDRFVYELFKAKHL-GNRD--FMKD-EESGGV-YLKKTGRK
CS4F1_LEPIN       RSSAEPLVLDLMELFRVSLCDMTLIGSINRKSW-IDED--F----EITKNKVWLSESGRK
CS4F1_MYXXD       RGTAGPLGLDVMELFRVPLADMPLVASVNRRAWDADAD--F----EVTSEHVWLSKAGRA
CAS1_HALVD        GERRFTLSLDIADIFKPILADRLVFRLVNRKQI-TTDD--F----ETELAGCLLTEQGRL
CAS1_NANEQ        RDTRYSLALDLSENFKPIITFRILIWLVNQGII-KDTH--F----VKGLNGVLLNEQGKK
CAS1B_THEYD       NFRRFTLNLDVAEIFKPIIADRAIFSIVNKRIV-KPQH--F----EKKLDGIVLNDKGKQ
CAS1_THEMA        NFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQI-NEKH--F----DEISEGLMLNDEGKS
CAS1_FUSNN        STRRFSLSLDISEVFKPLIVDRLIFSLLNKNQI-TEKS--F----VKDFEYLRLKEDVSK
CAS1_THEKO        GERRFSLALDLSEIFKPIIADRIANRLVKQGII-KREH--F----RGELNGVLLTKEGMK
CAS1_PYRHO        SERRFSLSLDLSEIFKPIIADRVANRLVKKGSL-KKEH--F----REDLNGVLLTEEGMK
D5VSN5_METIM      GTRRFSLALDLSEIFKPIYVDRLANRLVKQNII-KKSH--F----RDDLNGMLLTDEGMR
CAS1_METJA        HERRFSLALDLSEIFKPMIADRLANRLVKQGII-QKKH--F----RDDLNGVLLNKEGMK
CAS1B_ARCFU       SERRFSLALDIAELFKPVIVDRLIFYLVNNGIV-TESD--F----DSRLGGILLSEEGKK
CAS1_METTH        FERRYSLALDLSEIFKPTLIDRMIISLIKKKAI-KAED--F----EHGMNHCLLNNSGKR
CAS1A_METRM       AERRFSLALDLSEIFKPIIVDRVIFYLVNKKMI-TEKD--F----NQDLNCCLLNDKGRA
CAS1_CLOPS        STKRFSLSLDLAEIFKPLIVDSVIFNMINKGMI-KKSD--F----DTDEGICYLNENGRK
CAS1C_THEYD       SERRYSLSLDIAEIFKPLLADAIIFKLINNNMI-KLDD--F----EEDVNYCYLNESGRK
CAS1B_MOOTA       SERRYSLALDVAEIFKPVFVDRLIFRLINLNML-KETH--F----DTNVNFVYLTEGGRK
CAS1_AQUAE        STKRFSLSLDVAEVFKPIFVDNLIIRLIQENKI-DKTH--F----STELNMTFLNEIGRK
CAS1_METKA        RGRRPGLILDLMEEWRALAVDVPVLRRFLDGSL-SREM--FR---WKGDAVLLRDLDAVS
Q6ZEC7_SYNY3      QPYRPNLALDLMEEFRPVVVDQAIVRLLRSGIL-DPLD--FEP--SYDGLGIWLGITAKK
CAS1A_THET8       GRRSPALALDLMEEFRVPVVDQVVLSAFRRGLL-TPSH--AE---VREGGV-YLNEEGRR
CAS1C_RHORT       RPGRPSLALDLLEELRHPVVDRLALRICNLRKI-QPQH--FEPD-AERPGGVKLTVDGRK
CAS1D_METHJ       RHGKPALALDLLEEFRPVFCDAFVARLINKRMI-TKDD--F-------TQGSRLNDTAFK
CS4F1_GEOSL       RFGRPALALDMMEPFRPLIADSTVLMAINNGEI-RTGD--F----VRSAGGCNLTDSARK
CS4F1_RHORT       RPGRPALALDLIESFRPVLADSTVLMVLNNGEI-GTND--F----LYAGGGCALKPNARR
CAS1C_THET8       RYGRPSLALDLMEEFRSVLADSVVLSLLNNRRV-TLED--F----DDSEGFPRLRKEAWP
CAS1A_MOOTA       RSGRPALALDLMEEFRAILADRLALTLVNRRQI-DERD--FV---ERPGGAVHINDNARK
CAS1_LEPIN        RPGRPSLALDMMEEFRP-FIDRLVFTLINRKQI-QVSD--FL---EKPGSVFFINDDSRK
A6VNV5_ACTSZ      RPGRDSLAQDILEEFRAWWVDRMVLSLINRGQI-KPDD--FT---QEAGGAVNIKPDVRK
CAS1B_RHORT       RPGRPSLALDLMEELRPVLVDRLALSLINRRQL-RATD--FQ---RLDGGAVLLTDEARK
Q0AZN9_SYNWW      RPGRPSLALDLMEELRPYLGDRMVLSLINRKQI-NKDD--FI---TKENGAVYVLPDTRK
CAS1A_CHLTE       RPGRPSLALDMLEEFRSYIGDRLVLSLINRGQI-HAKD--FD---ISETGAVAMKDDARK
                        :  *  :  .                                            

Q3J7J6_NITOC      FLFQ-SIKRVAQL-----------------------------------------------
CAS1_PECAS        VMIG-SLQDVASKL-----------------------SQVVR------------------
Q5NPQ6_ZYMMO      FMID-TIKKIALSMEAEPAL----------------------------------------
CAS1_PSEAB        FMID-TLKDVAQRSTVSA------------------------------------------
E1V4T7_HALED      FMID-TLKAVALD---------------------------------LGGP-EA-------
Q6NEQ3_CORDI      GMLE-ALMEVLTPYLPNR----NDDRLIGDSDEVKGHIQYGKEIN---------------
CAS1B_CHLTE       RVIEIDLLGKIGPDIE---------------------TILGKKQ----------------
I3Y7Y6_THIV6      AMID-RIKKVIRMEETDA----------------------------SGHDRDP-------
CAS1A_RHORT       KIIP-DIEEILRAGGLEPPL--DAPEAVDPVIPPEE-PSGDDGH--RG------------
CAS1C_METHJ       RIIP-TIEEVLTAGGISAPAPPDWVVPPAIPVDEEG------------------------
CAS1_ECOLI        KLIP-LIEDVLAAGEIQPPAPPEDAQPVAIPLPVSLGDAGHRSS----------------
CAS1_GEOSL        RIIP-TIEQVLAAG--------GMDVPTPPPESVEAVIPNKEGI--GDAGHRG-------
CAS1B_THET8       DLLN-LFRGLGLPEEEDPVE--EDPTRPGGLWDLEG-EVEGGVA--YGGDDPG-------
C7QEM2_CATAD      RCVD-DVKALLTTPNNEPGSSDATDTGFFDQVQLQS--DRETEV--EGGRNYA-------
F4H8A4_CELFA      RCSS-DIHNLLLPAEPDEATA-DLGPDVVRLWDGGTRTVAGGTS--WGDEVDW-------
CAS1_CLOSS        TIVR-DIQLLFGIKEEEQLN--VEPLSLWDNREGNIKYGINYSN--ENED----------
Q03C58_LACP3      RMVA-DLKMLLGDVDDDLDA--DVVNLWDDKLGLQK-FGVSYRE--STEDGQS-------
CAS1_STRTR        IFSE-TYLYN------------GKEMYLSNIVSDYT-KKVIKALNQLGEEIPE-------
Q73QW5_TREDE      VLIN-NKEHYLNKAIE------IFVHSIFDALNEKD-ISQINFY--RNEL----------
CAS1_NEIM8        STLA-AIDKMVSSFQAGVTDKNAKQLKLPEILPLKE-YQYE-------------------
A6GZS0_FLAPJ      HLLS-IATIDVCID--------GKNSPLMVAMSRTT-HSLQECF--AGAARKI-------
CAS1B_METHJ       ELIH-LFSKSIQEE----------------LINTQI-DVLIQSL--RGEA-QF-------
CAS1_THEPD        KAMK-RLYRYLSAKHRE-----TGKTPYQQ-IHLKA-FCLAKHL--EGKCSRE-------
CAS1_MYCTU        SIAR-AFGNRIARTATYIKGD-PHRYTFQYALDLQL-QSLVRVI--EAGH-PSRLVDIDI
CAS1_MYCTO        SIAR-AFGNRIARTATYIKGD-PHRYTFQYALDLQL-QSLVRVI--EAGH-PSRLVDIDI
CAS1A_METHJ       KYAA-AVLTRIHGKVKYEEQ------TFQDIFKRQA-ERIGKAL--TEGD-EY-------
Q8PS38_METMA      KIVN-EFSNTLNKKVSYQ----GKESTWSYVIFLKV-RELAHYL--TSKKEKLDFTKPEY
CAS1B_SACS2       DLAK-LIRKGMEENVKEESD--HNPKTLIQAIRAHA-VKLASSI--REGK-EY-------
CAS1A_SACS2       TVYS-LFSDVKEDE-----------------IYTQA-RRLVNAI--LNDE-EY-------
CAS1_KORCO        FFSD-FMNWRLDYK--------GRKLGMETIMFLYV-RDIVSFL--RGGKEPT-------
CAS1_HYPBU        CIATLVLENIYKTPYPDSR---GRKKTLRDHIYTYA-WNLAAAI--RQHK-PY-------
CAS1A_ARCFU       LLLA-SLLERLDSKTQYR----GRNLAYSSIILLHA-RDVVAFL--RGER-RY-------
CAS1B_METRM       LLIA-KILDKLNSKIMFH----SKNISYSDIILYQG-KLMADYL--TNGV-PY-------
CAS1C_METRM       LIIG-RVLDKVNSNINYE----GENLSYAQIIDKQA-KKIVNYL--INGE-KY-------
Q7MR72_WOLSU      KIIT-EINATMNKKHLYN----GKNLSLQGVMQRQV-YRLVGAF--MQQN-RY-------
G0GAL1_SPITZ      MIAE-KILERLETPAPFR----GKRHPLRAIIQIQA-RSIATFF--RGERKDY-------
CAS1A_PYRAE       MLVE-EWTGERLEPVIARQV-----------------GLAVAHL--HGQR-AY-------
CAS1B_PYRAE       RLAA-AVLEEFN----------ATGRPLSAEIHREA-RSIAKAL--CTS-----------
CAS1A_THEYD       KFYP-LYEQWVQQQ--------------RTIWRGEV-QGFARRI--LEEK-DI-------
CS4F1_LEPIN       KATQ-LYETRLDDTWKHPVV--NYSLSYYRMIELEV-RLLEKEW--SGEANIF-------
CS4F1_MYXXD       KAIE-LYERRKRETWKNNVL--GYSLSYARLVELEV-RLLEKEW--TGKPGLF-------
CAS1_HALVD        TVLE-EFERSLDQTVQHPRL--KRKVSFKTLIQTDV-YSLKKHL--LTGE-PY-------
CAS1_NANEQ        LVIK-EFNKRLDETIKLKS---GLKRSMRWYIKAQA-YNLERFL--LDGR-KF-------
CAS1B_THEYD       ILLQ-EMDERLRSTIQHKKL--GRHVSYRQLIRLEL-YKIQKHL--MEEE-EY-------
CAS1_THEMA        LFVK-NYEQALRETVFHKKL--NRYVSMRSLIKMEL-HKLEKHL--IGEQ-VF-------
CAS1_FUSNN        LIVQ-EFEDRLKQIITHKDL--NRKISYQYLVRLEC-YKLIKHL--LGEK-KY-------
CAS1_THEKO        VVLK-AYNEELGRSVKHPGL--KKNVTKQRLIRLEA-YKLIKHL--VGVK-DY-------
CAS1_PYRHO        IVTK-AYNEELQKSVKHPKI--GSNVTRQRLIRLEA-YKLIKHL--VGVE-EY-------
D5VSN5_METIM      LVIK-FFNELLESTVKHPKL--NKNVSKKRLIRLEC-YKLIKHL--LEVN-KY-------
CAS1_METJA        VVLE-HFNKEMDKTVNHKKL--KKNVSKRRLIRLEA-YKLVKHL--VGQK-RY-------
CAS1B_ARCFU       KFVR-HFNERLEKTVKHRKL--NRKVSYQRLIRLEC-YKLVKHF--TAVE-KY-------
CAS1_METTH        KFLA-EYDRRLGKTVKHREL--GRKVSYRRLIRLEA-YKLIKHL--IGQK-SY-------
CAS1A_METRM       TFVK-EYNKRLETTIKHKDL--GRKVSYQRLIRLEA-YKLKKHV--FGMK-EY-------
CAS1_CLOPS        KFIK-EYENKLSTTVRHRTL--NRNVSYRELIRLEC-YKLIKML--LGDE-DY-------
CAS1C_THEYD       KFIR-EFDQKLSTTIKHRKL--KRNVSYRTIIRIEC-YKLIKHF--IGDE-VY-------
CAS1B_MOOTA       VFVK-EFEETLEKTILHRKL--KRNIRYKSLVRLDL-YKLIKHL--LGEE-KY-------
CAS1_AQUAE        VFLK-AFNELLETTIFYPKL--NRKVSHRTLIKLEL-YKLIKHL--LEEE-VY-------
CAS1_METKA        APVL-TVLSRVRGGLLEAVD--RRIREVRDGVSRQSPPEPLEFD--PEDV----------
Q6ZEC7_SYNY3      LFLT-ELESILQTSFLYSPQ--SRRLKLQQIILEQA-RCLGRCC--LESSLDY-------
CAS1A_THET8       RLIQ-LFEERLLEGVSHPL---GFRKPLGETIEVQA-QRLKAAL--LGRG-RY-------
CAS1C_RHORT       IFLE-EWEGHLARPLREPGVAAEHRLDVHRLLQRQV-DRLVSDL--RGGE-PY-------
CAS1D_METHJ       KYLG-FYHDFMEESLKHPRF--KYSVSRKKAIQIQA-IIFRKAI--CGELKGY-------
CS4F1_GEOSL       RFIA-GFERRMEQEVTHPIF--KYTISYRRLLEVQA-RLLTRYL--SGEIPAY-------
CS4F1_RHORT       GLIA-AYERRLDQETTHPVF--GYQLSMRRLIQVQA-RLLARFV--SGDIPRY-------
CAS1C_THET8       KFLR-AWEGRLNERIQHPLL--GKRLAYREILLAQA-RILVKHL--LGELPRY-------
CAS1A_MOOTA       EIAI-AYQKRKQEEVLHPVL--NRKVPLGLVPHIQA-RLLARVL--RGDAEEY-------
CAS1_LEPIN        ELIK-SYQERKKEEIFHPWL--NIKSTVGELPYLQA-RIFARTL--RGDLKYY-------
A6VNV5_ACTSZ      LIFQ-TLQAKKQEKITHPFL--GEEVEIGLLPYIQS-MLLARHL--RGDLAEY-------
CAS1B_RHORT       TVLS-AWQERKKQERRHPFL--EESAPLGLVPYLQA-QMLARHL--RGDLDAY-------
Q0AZN9_SYNWW      MLLT-VWQKRKQEEIIHPYL--EEKIPIGLLPYTQA-LLLARFL--RGDLDAY-------
CAS1A_CHLTE       TLIT-AYQQRKQEEIEHPFV--GEKMAVGLLWHMQA-MLLARYI--RGDIDMY-------
                                                                              

Q3J7J6_NITOC      ------------------------------------------------------------
CAS1_PECAS        ------------------------------------------------------------
Q5NPQ6_ZYMMO      ------------------------------------------------------------
CAS1_PSEAB        ------------------------------------------------------------
E1V4T7_HALED      ------------------------------------------------------------
Q6NEQ3_CORDI      ------------------------------------------------------------
CAS1B_CHLTE       ------------------------------------------CSS---------------
I3Y7Y6_THIV6      ------------------------------------------------------------
CAS1A_RHORT       ------------------------------------------------------------
CAS1C_METHJ       ------------------------------------------------------------
CAS1_ECOLI        ------------------------------------------------------------
CAS1_GEOSL        ------------------------------------------------------------
CAS1B_THET8       ------------------------------------------EGAEEPEG----------
C7QEM2_CATAD      ------------------------------------------DEL------------GTT
F4H8A4_CELFA      ------------------------------------------------------------
CAS1_CLOSS        ------------------------------------------------------------
Q03C58_LACP3      ------------------------------------------------------------
CAS1_STRTR        ------------------------------------------FRI---------------
Q73QW5_TREDE      ------------------------------------------------------------
CAS1_NEIM8        ------------------------------------------------------------
A6GZS0_FLAPJ      -----------------------------------------LYPI------------YV-
CAS1B_METHJ       ------------------------------------------SII------------KP-
CAS1_THEPD        ------------------------------------------KLA------------FT-
CAS1_MYCTU        TS----------------------------------------EPS------------GA-
CAS1_MYCTO        TS----------------------------------------EPS------------GA-
CAS1A_METHJ       ------------------------------------------VPY------------RYR
Q8PS38_METMA      EIERIDSYDIRQKILSISYVDWKKLGFSKGTLHYMKQNAKSDKPFTLNAHVLERVNKWE-
CAS1B_SACS2       ------------------------------------------RGF------------KLV
CAS1A_SACS2       ------------------------------------------RPY------------LAK
CAS1_KORCO        ------------------------------------------MPY-------------IP
CAS1_HYPBU        ------------------------------------------KPF------------IVG
CAS1A_ARCFU       ------------------------------------------EGF------------VQK
CAS1B_METRM       ------------------------------------------EGF------------SLR
CAS1C_METRM       ------------------------------------------TGF------------SLR
Q7MR72_WOLSU      ------------------------------------------KSY------------IFK
G0GAL1_SPITZ      ------------------------------------------TPY------------RMR
CAS1A_PYRAE       ------------------------------------------TPH------------QL-
CAS1B_PYRAE       ------------------------------------------------------------
CAS1A_THEYD       ------------------------------------------ISG---------------
CS4F1_LEPIN       ------------------------------------------AQA------------RLR
CS4F1_MYXXD       ------------------------------------------ATF------------RLR
CAS1_HALVD        ------------------------------------------HAT------------EK-
CAS1_NANEQ        ------------------------------------------KAF------------RLI
CAS1B_THEYD       ------------------------------------------KPF------------VTG
CAS1_THEMA        ------------------------------------------GSE------------E--
CAS1_FUSNN        ------------------------------------------KSF------------QM-
CAS1_THEKO        ------------------------------------------EPL------------VA-
CAS1_PYRHO        ------------------------------------------KPL------------VA-
D5VSN5_METIM      ------------------------------------------SPL------------IA-
CAS1_METJA        ------------------------------------------EPL------------VA-
CAS1B_ARCFU       ------------------------------------------SPF------------VM-
CAS1_METTH        ------------------------------------------EPF------------VM-
CAS1A_METRM       ------------------------------------------DPF------------VI-
CAS1_CLOPS        ------------------------------------------KPL------------KA-
CAS1C_THEYD       ------------------------------------------APF------------KA-
CAS1B_MOOTA       ------------------------------------------SPM------------KV-
CAS1_AQUAE        ------------------------------------------LPL------------NYG
CAS1_METKA        ---------------------------------------------------------GVV
Q6ZEC7_SYNY3      ------------------------------------------EPF------------TLS
CAS1A_THET8       ------------------------------------------TPF------------YL-
CAS1C_RHORT       ------------------------------------------RPF------------RFG
CAS1D_METHJ       ------------------------------------------YPF------------IYA
CS4F1_GEOSL       ------------------------------------------PNF------------VTR
CS4F1_RHORT       ------------------------------------------PHY------------CPR
CAS1C_THET8       ------------------------------------------EPF------------AVR
CAS1A_MOOTA       ------------------------------------------LPF------------MYR
CAS1_LEPIN        ------------------------------------------IPF--------------I
A6VNV5_ACTSZ      ------------------------------------------PPF------------LMR
CAS1B_RHORT       ------------------------------------------PPW--------------F
Q0AZN9_SYNWW      ------------------------------------------PAF--------------I
CAS1A_CHLTE       ------------------------------------------PPF--------------V
                                                                              

Q3J7J6_NITOC      ----------
CAS1_PECAS        ----------
Q5NPQ6_ZYMMO      ----------
CAS1_PSEAB        ----------
E1V4T7_HALED      ----------
Q6NEQ3_CORDI      ----------
CAS1B_CHLTE       ----------
I3Y7Y6_THIV6      ----------
CAS1A_RHORT       ----------
CAS1C_METHJ       ----------
CAS1_ECOLI        ----------
CAS1_GEOSL        ----------
CAS1B_THET8       ----------
C7QEM2_CATAD      W---------
F4H8A4_CELFA      ----------
CAS1_CLOSS        ----------
Q03C58_LACP3      ----------
CAS1_STRTR        ----------
Q73QW5_TREDE      ----------
CAS1_NEIM8        ----------
A6GZS0_FLAPJ      ----------
CAS1B_METHJ       ----------
CAS1_THEPD        WDKKRYIIHE
CAS1_MYCTU        ----------
CAS1_MYCTO        ----------
CAS1A_METHJ       T---------
Q8PS38_METMA      ALVSSQR---
CAS1B_SACS2       M---------
CAS1A_SACS2       ----------
CAS1_KORCO        W---------
CAS1_HYPBU        RL--------
CAS1A_ARCFU       W---------
CAS1B_METRM       W---------
CAS1C_METRM       W---------
Q7MR72_WOLSU      W---------
G0GAL1_SPITZ      W---------
CAS1A_PYRAE       ----------
CAS1B_PYRAE       ----------
CAS1A_THEYD       ----------
CS4F1_LEPIN       ----------
CS4F1_MYXXD       ----------
CAS1_HALVD        WW--------
CAS1_NANEQ        Y---------
CAS1B_THEYD       W---------
CAS1_THEMA        ----------
CAS1_FUSNN        WW--------
CAS1_THEKO        WF--------
CAS1_PYRHO        WF--------
D5VSN5_METIM      WF--------
CAS1_METJA        WF--------
CAS1B_ARCFU       WW--------
CAS1_METTH        WW--------
CAS1A_METRM       WW--------
CAS1_CLOPS        WW--------
CAS1C_THEYD       WW--------
CAS1B_MOOTA       WW--------
CAS1_AQUAE        GLK-------
CAS1_METKA        WDALEV----
Q6ZEC7_SYNY3      ----------
CAS1A_THET8       W-R-------
CAS1C_RHORT       TSRPG-----
CAS1D_METHJ       R---------
CS4F1_GEOSL       ----------
CS4F1_RHORT       ----------
CAS1C_THET8       ----------
CAS1A_MOOTA       ----------
CAS1_LEPIN        WK--------
A6VNV5_ACTSZ      ----------
CAS1B_RHORT       WK--------
Q0AZN9_SYNWW      WK--------
CAS1A_CHLTE       WR--------