Home | Contact

Species code:	CLOBB
Taxonomy:	Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium (TaxID: 508765) [NEWT/ NCBI]
Description:	Clostridium botulinum produces botulinum neurotoxin, one of deadliest toxins known. It inhibits acetylcholine release in neuromuscular junctions, causing paralysis by inhibiting muscle contraction. In most cases the affected person dies of asphyxiation or heart failure. Strains of C. botulinum are physiologically heterogeneous, and four distinct phenotypic groups (I to IV) are recognized. These four metabolically distinct groups do not, however, necessarily correlate with the serological specificities of the botulinum neurotoxin produced, which are classified into 7 serotypes, A-F. The type A toxin is used in minute doses to treat both painful muscle spasms and as a cosmetic treatment to temporarily remove frown lines between eyebrows. Type B nonproteolytic outbreaks of botulinum poisoning are often associated with the consumption of fish. The strains are usually psychrotrophs. C.botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism, although it does produce neurotoxin.
Properties:	Presence of flagella: Yes Human pathogen: not known Interaction: Saprophyte; Animal pathogen in Mammalia Number of membranes: 1 Number of inteins:0
Statistics:	Number of CLOBB entries in the UniProt Knowledgebase: 3473 (284 in UniProtKB/Swiss-Prot + 3189 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome EMBL accession number CP001056 (circular; 3,800,327 bp) (download entry) • Plasmid pCLL EMBL accession number CP001057 (circular; 47,642 bp) (download entry)
Reference(s):	[1] Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S. ; "Complete sequence of Clostridium botulinum strain Eklund."; Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
Web links:	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=28857 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Cbot_Eklund17B Pathema: http://pathema.jcvi.org/tigr-scripts/Clostridium/shared/GenomePage.cgi?org=bcb3  EBI Proteome Analysis page

• Perform a BLAST search against all proteins from this proteome
  
  
• Download all UniProt Knowledgebase entries of this proteome
  • in UniProt Knowledgebase format
  • in FASTA format
  
  
• Retrieve set of characterized or identified proteins for this proteome
  
  
• Retrieve set of proteins with 3D structure for this proteome

Swiss Institute of Bioinformatics | Disclaimer