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HAMAP: Escherichia coli O157:H7 (strain EC4115 / EHEC) complete proteome
General information

Species:  Escherichia coli O157:H7 (strain EC4115 / EHEC)
Species code: ECO5E
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia (TaxID: 444450) [NEWT/ NCBI]
Description: Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesizing appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.

E.coli O157:H7 is a enterohemorrhagic (EHEC) strain producing large quantities of one or more related, potent toxins that cause severe damage to the lining of intestine. These toxins are closely related to the toxin produced by Shigella dysenteriae. The acute disease caused by the bacterium is called hemorrhagic colitis and is characterized by severe cramping and diarrhea. Undercooked or raw hamburger has been implicated in nearly all documented outbreaks and in other sporadic cases. The identifier O157:H7 refers to the serotype of EHEC, and reflects the specific antigenic markers found on the surface of the cell. EHEC attaches and effaces to cells in the large intestine.
Properties: Presence of flagella: Yes
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of ECO5E entries in the UniProt Knowledgebase: 5279 (748 in UniProtKB/Swiss-Prot + 4531 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    EC4115 / EHEC
Genome structure:
• Chromosome EMBL accession number CP001164 (circular; 5,572,075 bp) (download entry)
• Plasmid pO157 EMBL accession number CP001163 (circular; 94,644 bp) (download entry)
• Plasmid pEC4115 EMBL accession number CP001165 (circular; 37,452 bp) (download entry)
Reference(s):
[1] Eppinger M., Sebastian Y., Ravel J. ;
"Complete genome sequence of Escherichia coli O157:H7 str. EC4115.";
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
Web links:
Official genome site(s):
http://msc.jcvi.org/o157h7/ec4115/index.shtml
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=27739
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ecol_157H7_EC4115
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p27739_Esc_coli
 EBI Proteome Analysis page



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