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HAMAP: Mycoplasma gallisepticum (strain R(high / passage 156)) complete proteome
General information

Species:  Mycoplasma gallisepticum (strain R(high / passage 156))
Species code: MYCGH
Taxonomy: Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma (TaxID: 710128) [NEWT/ NCBI]
Description: Mycoplasma gallisepticum is responsible for chronic respiratory disease in chickens and infectious sinusitis in turkeys resulting in important economic losses.

The virulent, low-passage M. gallisepticum strain R (Rlow) has been serially passaged in broth culture to generate an attenuated high-passage strain (Rhigh). Relatively few total genomic changes (64 loci) occurred, yet they are potentially responsible for the observed attenuation of this strain. Comparison of the virulent low passage R(low) strain, this avirulent high passage R(high) strain and the live attenuated vaccine strain F revealed possible virulence determinants. Changes in sugar metabolism and solute transport functions were apparent in both attenuated strains, indicating that metabolic substrate utilization may be a significant mechanism by which strains exhibit phenotypic differences in the host (adapted from PMID 20123709).
Properties: Presence of flagella: No
Human pathogen: No
Interaction: Animal pathogen in Aves
Number of membranes: 1
Number of inteins:0
Statistics: Number of MYCGH entries in the UniProt Knowledgebase: 763 (1 in UniProtKB/Swiss-Prot + 762 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    R(high / passage 156)
Genome structure:
Chromosome EMBL accession number CP001872 (circular; 1,012,027 bp) (download entry)
Reference(s):
[1] PubMed=20123709; [ NCBI , EBI , Israel , Japan ]
Szczepanek S.M., Tulman E.R., Gorton T.S., Liao X., Lu Z., Zinski J., Aziz F., Frasca S. Jr., Kutish G.F., Geary S.J. ;
"Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum.";
Infect. Immun. 78:1760-1771(2010).
Web links:
Official genome site(s):
http://www.pathobiology.uconn.edu/people/faculty/indeste.html
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=43299
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mgal_Rhigh
GOLD: http://genomesonline.org/GOLD_CARDS/Gi05914.html
 EBI Proteome Analysis page



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