HAMAP: Neisseria meningitidis serogroup A complete proteome
General information

Species:  Neisseria meningitidis serogroup A
Species code: NEIMA
Taxonomy: Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria (TaxID: 65699) [NEWT/ NCBI]
Description: Gram-negative meningococcal bacterium. Neisseria meningitidis colonizes the mucosal surface of the human nose and throat, usually as a commensal bacterium. Up to 15% of the human population are asymptomatic carriers. Sometimes the strains can invade the host, causing life-threatening invasive bacterial infections especially in young infants. They do so by gaining access to the blood and to the cerebrospinal fluid to cause meningitis and septicemia. Thus it is a major cause of morbidity and mortality. Strains from serogroup A are responsible for major epidemics and pandemics of meningococcal disease.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal commensal in Mammalia; Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of NEIMA entries in the UniProt Knowledgebase: 1887 (552 in UniProtKB/Swiss-Prot + 1335 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    Z2491 / Serogroup A / Serotype 4A
Genome structure:
Chromosome EMBL accession number AL157959 (circular; 2,184,406 bp) (download entry)
Reference(s):
[1] MEDLINE=20222556; PubMed=10761919; [ NCBI , EBI , Israel , Japan ]
Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. ;
"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491.";
Nature 404:502-506(2000).
Web links:
Official genome site(s):
http://www.sanger.ac.uk/Projects/N_meningitidis/
Other web sites:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Neisseria&GLspecies=meningitidis&GLstrain=A_Z2491
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid122587%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Nmen_Z2491
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=ntnm01
Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Neisseria_meningitidis.html
NMPDR: http://www.nmpdr.org/FIG/wiki/rest.cgi/NmpdrPlugin/SeedViewer?pattern=122587.1;page=SearchResult
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p252_Nei_menin
 EBI Proteome Analysis page



Tools