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HAMAP: Streptococcus pyogenes serotype M1 complete proteome
General information

Species:  Streptococcus pyogenes serotype M1
Species code: STRP1
Taxonomy: Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus (TaxID: 301447) [NEWT/ NCBI]
Description: The group A streptococci (GAS, Streptococcus pyogenes) are gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains. Serotype M3 strains cause a higher rate of lethal infections than strains of other M types. In addition, serotype M3 and other GAS strains can undergo rapid shifts in disease frequency and display epidemic behaviour. Strict human pathogen responsible for a wide variety of diseases, including pharyngitis, scarlet fever, impetigo, septicemia, toxic shock syndrome, flesh-eating disease, rheumatic fever and acute glomerulonephritis. MGAS5005 was isolated in 1996 from the cerebrospinal fluid of an infected patient in Ontario, Canada, and has been used extensively in studies of GAS pathogenesis.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 1
Number of inteins:0
Statistics: Number of STRP1 entries in the UniProt Knowledgebase: 2307 (422 in UniProtKB/Swiss-Prot + 1885 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    ATCC 700294 / SF370 / Serotype M1
Genome structure:
Chromosome EMBL accession number AE004092 (circular; 1,852,441 bp) (download entry)
Reference(s):
[1] MEDLINE=21192684; PubMed=11296296; [ NCBI , EBI , Israel , Japan ]
Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E. ;
"Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
Web links:
Official genome site(s):
http://www.genome.ou.edu/strep.html
Other web sites:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Streptococcus&GLspecies=pyogenes&GLstrain=SF370
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=269
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_SF370
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=ntsp01
Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Streptococcus_pyogenes.html
NMPDR: http://www.nmpdr.org/FIG/wiki/rest.cgi/NmpdrPlugin/SeedViewer?pattern=160490.1;page=SearchResult
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p269_Str_pyoge
 EBI Proteome Analysis page

Strain:    ATCC BAA-947 / MGAS5005 / Serotype M1
Genome structure:
Chromosome EMBL accession number CP000017 (circular; 1,838,554 bp) (download entry)
Reference(s):
[1] PubMed=16088826; [ NCBI , EBI , Israel , Japan ]
Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. ;
"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.";
J. Infect. Dis. 192:771-782(2005).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Streptococcus&GLspecies=pyogenes&GLstrain=MGAS5005
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=13888
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_MGAS5005
NMPDR: http://www.nmpdr.org/FIG/wiki/rest.cgi/NmpdrPlugin/SeedViewer?pattern=293653.3;page=SearchResult
 EBI Proteome Analysis page



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