AC   MF_00037;
DC   Protein; auto
TR   HAMAP; MF_00037; -; 1; level=0
XX
Names: MurB
XX
ID   MURB
DE   RecName: Full=UDP-N-acetylenolpyruvoylglucosamine reductase;
DE            EC=1.3.1.98;
DE   AltName: Full=UDP-N-acetylmuramate dehydrogenase;
GN   Name=murB;
XX
CC   -!- FUNCTION: Cell wall formation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-
CC         N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine;
CC         Xref=Rhea:RHEA:12248, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:68483, ChEBI:CHEBI:70757; EC=1.3.1.98;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the MurB family.
XX
DR   PROSITE; PS51387; FAD_PCMH; 1; trigger=yes
DR   Pfam; PF01565; FAD_binding_4; 1; trigger=no
DR   Pfam; PF02873; MurB_C; 1; trigger=no
DR   NCBIfam; TIGR00179; MurB; 1; trigger=no
XX
KW   Cell cycle
KW   Cell division
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Cytoplasm
KW   FAD
KW   Flavoprotein
KW   NADP
KW   Oxidoreductase
KW   Peptidoglycan synthesis
XX
GO   GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity
GO   GO:0009252; P:peptidoglycan biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: MURB_ECOLI (P08373)
FT   ACT_SITE        159
FT   Condition: R
FT   ACT_SITE        229
FT                   /note="Proton donor"
FT   Condition: [CS]
FT   ACT_SITE        325
FT   Condition: E
XX
Size: 258-383;
Related: None;
Template: P18579; P08373; P61431;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAN, BACCR, CORGL
Plasmid: None
Comments: Possible wrong start in NOSS1 and SYNY3.
 Divergent sequences in BIFLO and TREPA.
XX
# Revision 1.39 2023/06/01
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