AC   MF_00127;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
TR   HAMAP; MF_00127; -; 1; level=0
XX
Names: His_tRNA_synth
XX
ID   SYH
case <OC:Bacteria> or <OC:Archaea>
DE   RecName: Full=Histidine--tRNA ligase;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidyl-tRNA synthetase;
DE            Short=HisRS;
else case <OG:Chloroplast>
DE   RecName: Full=Histidine--tRNA ligase, chloroplastic;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidyl-tRNA synthetase;
DE            Short=HisRS;
end case
GN   Name=hisS;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC         histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC         Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
case <OC:Bacteria>
CC   -!- SUBUNIT: Homodimer.
end case
case not <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
end case
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
XX
DR   Pfam; PF00587; tRNA-synt_2b; 1; trigger=no
DR   Pfam; PF03129; HGTP_anticodon; 1; trigger=no
DR   NCBIfam; TIGR00442; HisS; 1; trigger=no
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1; trigger=no
XX
case not <OG:Chloroplast>
KW   Cytoplasm
end case
KW   Aminoacyl-tRNA synthetase
KW   Protein biosynthesis
KW   Ligase
KW   ATP-binding
KW   Nucleotide-binding
XX
GO   GO:0005524; F:ATP binding
GO   GO:0004821; F:histidine-tRNA ligase activity
GO   GO:0006427; P:histidyl-tRNA aminoacylation
case not <OG:Chloroplast>
GO   GO:0005737; C:cytoplasm
end case
case <OG:Chloroplast>
GO   GO:0009507; C:chloroplast
end case
XX
FT   None
XX
Size: 403-523;
Related: MF_00125;
Template: P60906; P60911; P56194;
Scope:
 Bacteria
 Archaea
 Plastid
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAN, BACC1, BACCR, BACCZ, BACHK, SHOC1
Plasmid: None
Comments: Divergent TROW8 and TROWT; not shown in alignment.
 It is difficult to distinguish between hisS and hisZ families.
XX
# Revision 1.45 2023/11/28
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