AC   MF_00130;
DC   Protein; auto
TR   HAMAP; MF_00130; -; 1; level=0
XX
Names: RecU
XX
ID   RECU
DE   RecName: Full=Holliday junction resolvase RecU;
DE            EC=3.1.21.10;
DE   AltName: Full=Recombination protein U homolog;
GN   Name=recU;
XX
CC   -!- FUNCTION: Endonuclease that resolves Holliday junction intermediates in
CC       genetic recombination. Cleaves mobile four-strand junctions by
CC       introducing symmetrical nicks in paired strands. Promotes annealing of
CC       linear ssDNA with homologous dsDNA. Required for DNA repair, homologous
CC       recombination and chromosome segregation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage at a junction such as a reciprocal
CC         single-stranded crossover between two homologous DNA duplexes
CC         (Holliday junction).; EC=3.1.21.10;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Binds 1 Mg(2+) ion per subunit.;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the RecU family.
XX
DR   Pfam; PF03838; RecU; 1; trigger=no
DR   NCBIfam; TIGR00648; RecU; 1; trigger=no
XX
KW   Cytoplasm
KW   DNA damage
KW   DNA repair
KW   DNA recombination
KW   Endonuclease
KW   Hydrolase
KW   Magnesium
KW   Metal-binding
KW   Nuclease
XX
GO   GO:0004519; F:endonuclease activity
GO   GO:0000287; F:magnesium ion binding
GO   GO:0007059; P:chromosome segregation
GO   GO:0006310; P:DNA recombination
GO   GO:0006281; P:DNA repair
GO   GO:0005737; C:cytoplasm
XX
FT   From: RECU_GEOKA (Q5KXY4)
FT   BINDING         84
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: T
FT   BINDING         86
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
FT   BINDING         99
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: [DE]
FT   BINDING         118
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: Q
FT   SITE            101
FT                   /note="Transition state stabilizer"
FT   Condition: K
XX
Size: 157-213;
Related: None;
Template: P39792; Q5KXY4;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.30 2023/06/01
//