AC   MF_00405;
DC   Protein; auto
TR   HAMAP; MF_00405; -; 1; level=0
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Names: FabA
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ID   FABA
DE   RecName: Full=3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase;
DE            EC=4.2.1.59;
DE   AltName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA;
DE   AltName: Full=Beta-hydroxydecanoyl thioester dehydrase;
DE   AltName: Full=Trans-2-decenoyl-[acyl-carrier-protein] isomerase;
DE            EC=5.3.3.14;
GN   Name=fabA;
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CC   -!- FUNCTION: Necessary for the introduction of cis unsaturation into fatty
CC       acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-
CC       (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can
CC       catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with
CC       saturated chain lengths up to 16:0, being most active on intermediate
CC       chain length.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O;
CC         Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O;
CC         Xref=Rhea:RHEA:41860, Rhea:RHEA-COMP:9638, Rhea:RHEA-COMP:9639,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:78466, ChEBI:CHEBI:78467;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP];
CC         Xref=Rhea:RHEA:23568, Rhea:RHEA-COMP:9639, Rhea:RHEA-COMP:9927,
CC         ChEBI:CHEBI:78467, ChEBI:CHEBI:78798; EC=5.3.3.14;
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the thioester dehydratase family. FabA
CC       subfamily.
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DR   Pfam; PF07977; FabA; 1; trigger=no
DR   NCBIfam; TIGR01749; FabA; 1; trigger=no
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KW   Cytoplasm
KW   Fatty acid biosynthesis
KW   Fatty acid metabolism
KW   Isomerase
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Lyase
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GO   GO:0008693; F:(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
GO   GO:0034017; F:trans-2-decenoyl-acyl-carrier-protein isomerase activity
GO   GO:0006633; P:fatty acid biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   From: FABA_ECOLI (P0A6Q3)
FT   ACT_SITE        71
FT   Condition: H
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Size: 170-184;
Related: MF_00406;
Template: P0A6Q3;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.33 2023/06/01
//