AC   MF_00559;
DC   Protein; auto
TR   HAMAP; MF_00559; -; 1; level=0
XX
Names: G3P_dehdrog_arch
XX
ID   G3P
DE   RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase;
DE            Short=GAPDH;
DE            EC=1.2.1.59;
DE   AltName: Full=NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase;
GN   Name=gap;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-
CC         phospho-glyceroyl phosphate + H(+) + NADPH; Xref=Rhea:RHEA:10296,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57604,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:59776; EC=1.2.1.59;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-
CC         phospho-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.59;
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 1/5.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the glyceraldehyde-3-phosphate dehydrogenase
CC       family.
XX
DR   PROSITE; PS00071; GAPDH; 1; trigger=no
DR   Pfam; PF02800; Gp_dh_C; 1; trigger=no
DR   Pfam; PF00044; Gp_dh_N; 1; trigger=no
DR   NCBIfam; TIGR01546; GAPDH-II_archae; 1; trigger=no
XX
KW   Cytoplasm
KW   Glycolysis
KW   NAD
KW   NADP
KW   Oxidoreductase
XX
GO   GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO   GO:0006096; P:glycolytic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: G3P_PYRHO (O59494)
FT   BINDING         12..13
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [TS]-[IV]
FT   BINDING         140..142
FT                   /ligand="D-glyceraldehyde 3-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:59776"
FT   Condition: S-C-N
FT   BINDING         192..193
FT                   /ligand="D-glyceraldehyde 3-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:59776"
FT   Condition: H-[AG]
FT   ACT_SITE        141
FT                   /note="Nucleophile"
FT   Condition: C
FT   BINDING         111
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: G
FT   BINDING         167
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: R
FT   BINDING         298
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: Q
XX
Size: 334-354;
Related: None;
Template: P10618; P39460; O59494;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in METAC, METBF
Plasmid: None
Comments: None
XX
# Revision 1.30 2023/06/01
//