AC   MF_00587;
DC   Protein; auto
TR   HAMAP; MF_00587; -; 1; level=0
XX
Names: tRNA_methyltr_TrmY
XX
case <OC:Archaea>
ID   TRMY
DE   RecName: Full=tRNA (pseudouridine(54)-N(1))-methyltransferase;
DE            EC=2.1.1.257;
GN   Name=trmY;
else case <OC:Bacteria>
ID   TRMYL
DE   RecName: Full=Putative pseudouridine methyltransferase;
DE            EC=2.1.1.-;
end case
XX
case <OC:Archaea>
CC   -!- FUNCTION: Specifically catalyzes the N1-methylation of pseudouridine at
CC       position 54 (Psi54) in tRNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) +
CC         N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:55292, Rhea:RHEA-COMP:14140, Rhea:RHEA-COMP:14141,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:74890; EC=2.1.1.257;
CC   -!- SUBUNIT: Homodimer.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. TrmY family.
XX
DR   Pfam; PF04013; Methyltrn_RNA_2; 1; trigger=no
XX
KW   Cytoplasm
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
case <OC:Archaea>
KW   tRNA processing
end case
XX
case <OC:Archaea>
GO   GO:0030488; P:tRNA methylation
GO   GO:0008175; F:tRNA methyltransferase activity
end case
GO   GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity
GO   GO:0005737; C:cytoplasm
XX
FT   From: TRMY_METJA (Q59034)
FT   BINDING         179..184
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [LIV]-S-P-L-[ES]-L
FT   BINDING         136
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [LM]
FT   BINDING         156
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: G
FT   BINDING         189
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: C
XX
Size: 192-211;
Related: None;
Template: Q59034; D4GTL8;
Scope:
 Bacteria; Gammaproteobacteria
 Archaea
Fusion:
 Nter: <Unknown>
 Cter: None
Duplicate: None
Plasmid: None
Comments: Formation of 1-methylpseudouridine at position 54 of tRNA has never been identified
 in any bacterial tRNA sequenced so far. The bacterial and archaeal homologs may fulfill
 different functions. See PubMed:22274953.
 Unknown N-terminal domain in ARCFU.
 Divergent PYRAE not shown in alignment and not used in size range.
XX
# Revision 1.28 2022/11/19
//