AC   MF_00997;
DC   Protein; auto
TR   HAMAP; MF_00997; -; 1; level=0
XX
Names: Protease_BepA
XX
ID   BEPA
case <OC:Enterobacterales>
DE   RecName: Full=Beta-barrel assembly-enhancing protease;
DE            EC=3.4.-.-;
GN   Name=bepA;
else
DE   RecName: Full=Putative beta-barrel assembly-enhancing protease;
DE            EC=3.4.-.-;
end case
XX
CC   -!- FUNCTION: Functions as both a chaperone and a metalloprotease.
CC       Maintains the integrity of the outer membrane by promoting either the
CC       assembly or the elimination of outer membrane proteins, depending on
CC       their folding state.
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the peptidase M48 family. BepA subfamily.
XX
DR   PROSITE; PS50005; TPR; 1; trigger=no
DR   PROSITE; PS50293; TPR_REGION; 1; trigger=no
DR   Pfam; PF01435; Peptidase_M48; 1; trigger=no
DR   Pfam; PF07720; TPR_3; 1; trigger=no
DR   Pfam; PF07719; TPR_2; 1; trigger=no
DR   General; Signal; -; 1; trigger=yes
DR   REP; Repeat_TPR; TPR; 0-6; trigger=yes
XX
KW   Hydrolase
KW   Metalloprotease
KW   Periplasm
KW   Protease
KW   Signal
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0008233; F:peptidase activity
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0042597; C:periplasmic space
XX
FT   From: BEPA_ECOLI (P66948)
FT   ACT_SITE        137
FT   Condition: E
FT   ACT_SITE        205
FT                   /note="Proton donor"
FT   Condition: D
FT   BINDING         136
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         140
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         201
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: E
XX
Size: 435-600;
Related: None;
Template: P66948;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2022/11/19
//