AC   MF_01205;
DC   Protein; auto
TR   HAMAP; MF_01205; -; 1; level=0
XX
Names: YmdB
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ID   YMDB
DE   RecName: Full=O-acetyl-ADP-ribose deacetylase;
DE            EC=3.1.1.106;
DE   AltName: Full=Regulator of RNase III activity;
GN   Name=ymdB;
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CC   -!- FUNCTION: Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free
CC       acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by
CC       interacting directly with the region of the ribonuclease that is
CC       required for dimerization/activation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose +
CC         H(+); Xref=Rhea:RHEA:59244, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:142723;
CC         EC=3.1.1.106;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose +
CC         H(+); Xref=Rhea:RHEA:57060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30089, ChEBI:CHEBI:57967, ChEBI:CHEBI:83767;
CC         EC=3.1.1.106;
CC   -!- SUBUNIT: Homodimer. Interacts with RNase III.
CC   -!- SIMILARITY: Belongs to the YmdB family.
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DR   Pfam; PF01661; Macro; 1; trigger=no
DR   PROSITE; PS51154; MACRO; 1; trigger=yes
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KW   Hydrolase
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GO   GO:0001883; F:purine nucleoside binding
GO   GO:0008428; F:ribonuclease inhibitor activity
GO   GO:0019213; F:deacetylase activity
GO   GO:0042278; P:purine nucleoside metabolic process
GO   GO:0060701; P:negative regulation of ribonuclease activity
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FT   From: YMDB_ECOLI (P0A8D6)
FT   BINDING         11..12
FT                   /ligand="substrate"
FT   Condition: D-I
FT   BINDING         33..35
FT                   /ligand="substrate"
FT   Condition: G-V-D
FT   BINDING         122..126
FT                   /ligand="substrate"
FT   Condition: S-T-G-[IVA]-Y
FT   ACT_SITE        35
FT                   /note="Proton acceptor"
FT   Condition: D
FT   BINDING         25
FT                   /ligand="substrate"
FT   Condition: N
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Size: 160-190;
Related: None;
Template: P0A8D6;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: in PANVC
Plasmid: in PANVC
Comments: The family is restricted to Enterobacterales in order to avoid wrong matches.
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# Revision 1.40 2022/05/14
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