AC   MF_01671;
DC   Protein; auto
TR   HAMAP; MF_01671; -; 1; level=0
XX
Names: IolG
XX
ID   IOLG
case <OC:Bacillota>
DE   RecName: Full=Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase;
DE            EC=1.1.1.18;
DE            EC=1.1.1.369;
DE   AltName: Full=Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase;
DE            Short=MI 2-dehydrogenase/DCI 3-dehydrogenase;
else
DE   RecName: Full=Inositol 2-dehydrogenase;
DE            EC=1.1.1.18;
DE   AltName: Full=Myo-inositol 2-dehydrogenase;
DE            Short=MI 2-dehydrogenase;
end case
GN   Name=iolG;
XX
case <OC:Bacillota>
CC   -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) and D-chiro-
CC       inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-
CC       chiro-inositol (1KDCI), respectively.
else
CC   -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-
CC       inositol (2KMI or 2-inosose).
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose;
CC         Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC         ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18;
case <OC:Bacillota>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine;
CC         Xref=Rhea:RHEA:25832, ChEBI:CHEBI:15378, ChEBI:CHEBI:27372,
CC         ChEBI:CHEBI:50920, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.1.1.369;
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA;
CC       acetyl-CoA from myo-inositol: step 1/7.
end case
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family.
XX
DR   Pfam; PF01408; GFO_IDH_MocA; 1; trigger=no
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1; trigger=no
XX
KW   NAD
KW   Oxidoreductase
XX
GO   GO:0050112; F:inositol 2-dehydrogenase activity
GO   GO:0019310; P:inositol catabolic process
XX
Size: 329-366;
Related: None;
Template: P26935;
Scope:
 Bacteria; Actinomycetota
 Bacteria; Bacillota
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in PAEAT, MYCVP, SACEN
Plasmid: None
Comments: None
XX
# Revision 1.13 2023/01/26
//