AC   MF_01808;
DC   Protein; auto
TR   HAMAP; MF_01808; -; 1; level=0
XX
Names: Recomb_XerC_XerD
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ID   XERC
DE   RecName: Full=Tyrosine recombinase XerC;
GN   Name=xerC;
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case <OC:Enterobacterales>
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules. Binds
CC       cooperatively to specific DNA consensus sequences that are separated
CC       from XerD binding sites by a short central region, forming the
CC       heterotetrameric XerC-XerD complex that recombines DNA substrates. The
CC       complex is essential to convert dimers of the bacterial chromosome into
CC       monomers to permit their segregation at cell division. It also
CC       contributes to the segregational stability of plasmids. In the complex
CC       XerC specifically exchanges the top DNA strands.
CC   -!- ACTIVITY REGULATION: FtsK may regulate the catalytic switch between
CC       XerC and XerD in the heterotetrameric complex during the two steps of
CC       the recombination process.
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD, in which XerC interacts
CC       with XerD via its C-terminal region, XerD interacts with XerC via its
CC       C-terminal region and so on.
else
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules. The XerC-
CC       XerD complex is essential to convert dimers of the bacterial chromosome
CC       into monomers to permit their segregation at cell division. It also
CC       contributes to the segregational stability of plasmids.
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC subfamily.
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DR   Pfam; PF00589; Phage_integrase; 1; trigger=no
DR   Pfam; PF02899; Phage_integr_N; 1; trigger=no
DR   NCBIfam; TIGR02224; Recomb_XerC; 1; trigger=no
DR   PROSITE; PS51900; CB; 1; trigger=yes
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1; trigger=yes
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KW   Cell cycle
KW   Cell division
KW   Chromosome partition
KW   Cytoplasm
KW   DNA integration
KW   DNA recombination
KW   DNA-binding
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GO   GO:0009037; F:tyrosine-based site-specific recombinase activity
GO   GO:0007059; P:chromosome segregation
GO   GO:0006310; P:DNA recombination
GO   GO:0006313; P:DNA transposition
GO   GO:0005737; C:cytoplasm
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FT   From: XERC_ECOLI (P0A8P6)
FT   ACT_SITE        148
FT   Condition: R
FT   ACT_SITE        172
FT   Condition: K
FT   ACT_SITE        240
FT   Condition: H
FT   ACT_SITE        243
FT   Condition: R
FT   ACT_SITE        266
FT   Condition: H
FT   ACT_SITE        275
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT   Condition: Y
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Size: 250-356;
Related: MF_01807!;
Template: P0A8P6; P44818; Q51566;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in PSEAE, RALN1, CALS4
Plasmid: in PSEAE, RALN1, SYNE7
Comments: XerC is highly related to XerD and it is therefore difficult to
 discriminate them correctly. Most XerD proteins however contain a [ST]RQ
 tripeptide that allow to distinguish them from XerC.
 Entries that are matched by MF_01808 profile but not by MF_01807 are annotated as XerC.
 Entries that are matched by MF_01808 and MF_01807 profiles are annotated as XerD.
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# Revision 1.38 2023/11/28
//