AC   MF_02030;
DC   Protein; auto
TR   HAMAP; MF_02030; -; 1; level=0
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Names: WecA_Gammaproteo
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ID   WECA
DE   RecName: Full=Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase;
DE            EC=2.7.8.33;
DE   AltName: Full=UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase;
DE   AltName: Full=Undecaprenyl-phosphate GlcNAc-1-phosphate transferase;
GN   Name=wecA;
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CC   -!- FUNCTION: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from
CC       UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P),
CC       yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-
CC         D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-
CC         undecaprenyl diphosphate + UMP; Xref=Rhea:RHEA:28090,
CC         ChEBI:CHEBI:57705, ChEBI:CHEBI:57865, ChEBI:CHEBI:60392,
CC         ChEBI:CHEBI:62959; EC=2.7.8.33;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS O-antigen
CC       biosynthesis.
case <OC:Enterobacterales>
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC       antigen biosynthesis.
end case
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 4 family. WecA
CC       subfamily.
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DR   Pfam; PF00953; Glycos_transf_4; 1; trigger=no
DR   NCBIfam; TIGR02380; ECA_wecA; 1; trigger=no
DR   General; Transmembrane; -; 10-11; trigger=yes
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KW   Cell inner membrane
KW   Cell membrane
KW   Glycosyltransferase
KW   Lipopolysaccharide biosynthesis
KW   Magnesium
KW   Manganese
KW   Membrane
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0036380; F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
case <OC:Enterobacterales>
GO   GO:0009246; P:enterobacterial common antigen biosynthetic process
end case
GO   GO:0009243; P:O antigen biosynthetic process
GO   GO:0005886; C:plasma membrane
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FT   None
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Size: 320-390;
Related: None;
Template: P0AC78;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.7 2023/06/01
//