AC   MF_03003;
DC   Protein; auto
TR   HAMAP; MF_03003; -; 1; level=0
XX
Names: eIF3d
XX
ID   EIF3D
case <OC:Mammalia> or <OC:Viridiplantae>
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit D;
DE            Short=eIF3d;
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 7;
DE   AltName: Full=eIF-3-zeta;
else case <OC:Fungi>
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit D;
DE            Short=eIF3d;
else
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit D;
DE            Short=eIF3d;
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 7;
end case
case <OC:Vertebrata>
GN   Name=EIF3D; Synonyms=EIF3S7;
else case <OC:Caenorhabditis>
GN   Name=eif-3.D;
else case <OC:Drosophilidae>
GN   Name=eIF3d; Synonyms=eIF3-S7;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, a complex required for several
CC       steps in the initiation of protein synthesis of a specialized
CC       repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome
CC       and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-
CC       tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The
CC       eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning
CC       of the mRNA for AUG recognition. The eIF-3 complex is also required for
CC       disassembly and recycling of post-termination ribosomal complexes and
CC       subsequently prevents premature joining of the 40S and 60S ribosomal
CC       subunits prior to initiation. The eIF-3 complex specifically targets
CC       and initiates translation of a subset of mRNAs involved in cell
CC       proliferation, including cell cycling, differentiation and apoptosis,
CC       and uses different modes of RNA stem-loop binding to exert either
CC       translational activation or repression. In the eIF-3 complex, EIF3D
CC       specifically recognizes and binds the 7-methylguanosine cap of a subset
CC       of mRNAs.
else
CC   -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. In the
CC       eIF-3 complex, eif3d specifically recognizes and binds the 7-
CC       methylguanosine cap of a subset of mRNAs.
end case
case <OC:Mammalia>
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC       EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC       EIF3M. The eIF-3 complex appears to include 3 stable modules: module A
CC       is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of
CC       EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D,
CC       EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and
CC       EIF3H of module B, thereby linking the three modules. EIF3J is a labile
CC       subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex
CC       interacts with RPS6KB1 under conditions of nutrient depletion.
CC       Mitogenic stimulation leads to binding and activation of a complex
CC       composed of MTOR and RPTOR, leading to phosphorylation and release of
CC       RPS6KB1 and binding of EIF4B to eIF-3.
else case <OC:Vertebrata> and not <OC:Mammalia>
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A),
CC       @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G),
CC       @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and
CC       @gn(EIF3M).
else case <OC:Drosophilidae>
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
else
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: The RNA gate region regulates mRNA cap recognition to prevent
CC       promiscuous mRNA-binding before assembly of eif3d into the full
CC       eukaryotic translation initiation factor 3 (eIF-3) complex.
case <OC:Mammalia>
CC   -!- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
end case
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit D family.
XX
DR   Pfam; PF05091; eIF-3_zeta; 1; trigger=no
XX
KW   Cytoplasm
KW   Initiation factor
KW   Protein biosynthesis
case <OC:Mammalia>
KW   Phosphoprotein
KW   RNA-binding
end case
XX
GO   GO:0003743; F:translation initiation factor activity
GO   GO:0003723; F:RNA binding
GO   GO:0098808; F:mRNA cap binding
GO   GO:0001732; P:formation of cytoplasmic translation initiation complex
GO   GO:0002191; P:cap-dependent translational initiation
GO   GO:0002183; P:cytoplasmic translational initiation
GO   GO:0005737; C:cytoplasm
GO   GO:0005852; C:eukaryotic translation initiation factor 3 complex
GO   GO:0016282; C:eukaryotic 43S preinitiation complex
GO   GO:0033290; C:eukaryotic 48S preinitiation complex
XX
FT   From: EIF3D_HUMAN (O15371)
FT   REGION          285..299
FT                   /note="RNA gate"
XX
Size: 509-619;
Related: None;
Template: O15371; O70194; O94236; K7IM66;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in DROAN, DROER, DROGR, DROME, DROMO, DROPE, DROPS, DROSE, DROSI,
 DROVI, DROWI, DROYA
Plasmid: None
Comments: None
XX
# Revision 1.17 2021/03/19
//