AC   MF_03163;
DC   Protein; auto
c?   <OC:Eukaryota>
TR   HAMAP; MF_03163; -; 1; level=0
XX
Names: RNA_methyltr_E_SPB1
XX
ID   SPB1
case <OC:Fungi>
DE   RecName: Full=AdoMet-dependent rRNA methyltransferase <gene_name>;
DE            EC=2.1.1.-;
DE   AltName: Full=2'-O-ribose RNA methyltransferase;
DE   AltName: Full=S-adenosyl-L-methionine-dependent methyltransferase;
GN   Name=SPB1;
else case <OC:Vertebrata>
DE   RecName: Full=pre-rRNA processing protein FTSJ3;
DE            EC=2.1.1.-;
DE   AltName: Full=2'-O-ribose RNA methyltransferase SPB1 homolog;
DE   AltName: Full=Protein ftsJ homolog 3;
DE   AltName: Full=Putative rRNA methyltransferase 3;
GN   Name=FTSJ3;
else
DE   RecName: Full=Putative rRNA methyltransferase;
DE            EC=2.1.1.-;
DE   AltName: Full=2'-O-ribose RNA methyltransferase SPB1 homolog;
end case
XX
case <OC:Fungi>
CC   -!- FUNCTION: Required for proper assembly of pre-ribosomal particles
CC       during the biogenesis of the 60S ribosomal subunit.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-
CC         methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:48628, Rhea:RHEA-COMP:12164, Rhea:RHEA-COMP:12165,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90675, ChEBI:CHEBI:90676;
CC   -!- SUBUNIT: Component of the nucleolar and nucleoplasmic pre-60S ribosomal
CC       particle.
else case <OC:Vertebrata>
CC   -!- FUNCTION: Probable methyltransferase involved in the processing of the
CC       34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-
CC         methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:48628, Rhea:RHEA-COMP:12164, Rhea:RHEA-COMP:12165,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90675, ChEBI:CHEBI:90676;
CC   -!- SUBUNIT: Interacts with NIP7.
else
CC   -!- FUNCTION: Probable methyltransferase involved in the maturation of rRNA
CC       and in the biogenesis of ribosomal subunits.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-
CC         methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:48628, Rhea:RHEA-COMP:12164, Rhea:RHEA-COMP:12165,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90675, ChEBI:CHEBI:90676;
end case
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
XX
DR   Pfam; PF11861; DUF3381; 1; trigger=no
DR   Pfam; PF01728; FtsJ; 1; trigger=no
DR   Pfam; PF07780; Spb1_C; 1; trigger=no
DR   Pfam; PF02520; DUF148; 1; trigger=no
DR   PROSITE; PS50312; ASP_RICH; 0-unlimited; trigger=strict
DR   PROSITE; PS50313; GLU_RICH; 0-unlimited; trigger=strict
DR   PROSITE; PS50318; LYS_RICH; 0-unlimited; trigger=strict
DR   General; Coiled_coil; -; 0-unlimited; trigger=strict
XX
KW   Methyltransferase
KW   Nucleus
KW   Ribosome biogenesis
KW   rRNA processing
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0005730; C:nucleolus
case <OC:Fungi>
GO   GO:0030687; C:preribosome, large subunit precursor
GO   GO:0070039; F:rRNA (guanosine-2'-O-)-methyltransferase activity
GO   GO:0008650; F:rRNA (uridine-2'-O-)-methyltransferase activity
else case <OC:Vertebrata>
GO   GO:0030688; C:preribosome, small subunit precursor
GO   GO:0008649; F:rRNA methyltransferase activity
else
GO   GO:0008649; F:rRNA methyltransferase activity
end case
GO   GO:0031167; P:rRNA methylation
XX
FT   From: SPB1_YEAST (P25582)
FT   ACT_SITE        159
FT                   /note="Proton acceptor"
FT   Condition: K
FT   BINDING         58
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: G
FT   BINDING         60
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: [WF]
FT   BINDING         78
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: D
FT   BINDING         94
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: [DN]
FT   BINDING         119
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: D
XX
Size: 736-1019;
Related: MF_01547; MF_03162;
Template: P25582; Q8IY81;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: in SOYBN
Plasmid: None
Comments: None
XX
# Revision 1.11 2023/02/07
//