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HAMAP annotation rule: MF_00052
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General rule information

Accession MF_00052
Dates 1-JUN-2001 (Created)
9-DEC-2011 (Last updated, Version 24)
Data class Protein

case <OC:Bacteria>
Predictors HAMAP; MF_00052_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00052_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_00052_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00052_A]
end case

Names RNase_HII


Propagated annotation

Identifier, protein and gene names
Identifier RNH2
Protein name
RecName: Full=Ribonuclease HII;
Short=RNase HII;
EC=3.1.26.4;
Gene name rnhB
Comments
FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (By similarity).
CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-phosphomonoester.
COFACTOR: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the RNase HII family.
Cross-references
Pfam PF01351; RNase_HII; 1;
TIGRFAMs TIGR00729; TIGR00729; 1;
Keywords
Cytoplasm, Hydrolase, Nuclease, Endonuclease, Manganese, Metal-binding.
Gene Ontology
GO:0030145; Molecular function: manganese ion binding.
GO:0004523; Molecular function: ribonuclease H activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.
Features

case <OC:Bacteria>
From: RNH2_ECOLI (P10442)
Key     From     To       Description   Condition   FTGroup
METAL     16     16       Divalent metal cation (By similarity)   D  
METAL     17     17       Divalent metal cation (By similarity)   E  
METAL     108     108       Divalent metal cation (By similarity)   D  
end case

case <OC:Archaea>
From: RNH2_METJA (Q57599)
Key     From     To       Description   Condition   FTGroup
METAL     7     7       Divalent metal cation (By similarity)   D  
METAL     8     8       Divalent metal cation (By similarity)   E  
METAL     112     112       Divalent metal cation (By similarity)   D  
end case



Additional information


case <OC:Bacteria>
Size range: 181-315 amino acids
end case


case <OC:Archaea>
Size range: 195-277 amino acids
end case

Related UniRules: None
Template: O31744 (RNH2_BACSU); P10442 (RNH2_ECOLI); O29634 (RNH2_ARCFU); Q57599 (RNH2_METJA); O74035 (RNH2_PYRKO): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in METPP, SYMTH, SYNFM
Plasmid encoded: in METPP
Comments: Divergent CAUCR not shown in alignment. Possible wrong start in a number of cases.

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UniProtKB rule member sequences