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HAMAP annotation rule: MF_00054
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General rule information

Accession MF_00054
Dates 1-JUN-2001 (Created)
11-MAY-2011 (Last updated, Version 26)
Data class Protein

case <OC:Bacteria>
Predictors HAMAP; MF_00054_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00054_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_00054_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00054_A]
end case

Names EF-G_EF-2


Propagated annotation

Identifier, protein and gene names

case <OC:Bacteria>
Identifier EFG
Protein name
RecName: Full=Elongation factor G;
Short=EF-G;
end case


case <OC:Archaea>
Identifier EF2
Protein name
RecName: Full=Elongation factor 2;
Short=EF-2;
end case

Gene name fusA
Comments
FUNCTION: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
Cross-references
Pfam PF00679; EFG_C; 1;
PF00009; GTP_EFTU; 1;
PF03144; GTP_EFTU_D2; 1;
PRINTS PR00315; ELONGATNFCT; 1;
TIGRFAMs TIGR00231; Small_GTP; 1;
TIGR00484; EF-G; 1;
TIGR00490; AEF-2; 1;
PROSITE PS00301; EFACTOR_GTP; 1;
Keywords

case <FT:4> or <FT:5>
Acetylation.
end case

Cytoplasm, Elongation factor, Protein biosynthesis, GTP-binding, Nucleotide-binding.
Gene Ontology
GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.
GO:0006414; Biological process: translational elongation.
GO:0005737; Cellular component: cytoplasm.
Features

case <OC:Bacteria>
From: EFG_ECOLI (P0A6M8)
Key     From     To       Description   Condition   FTGroup
NP_BIND     17     24       GTP (By similarity)      
NP_BIND     88     92       GTP (By similarity)      
NP_BIND     142     145       GTP (By similarity)      
end case

case <OC:Escherichia> or <OC:Shigella>
Key     From     To       Description   Condition   FTGroup
MOD_RES     504     504       N6-acetyllysine (By similarity)   K  
MOD_RES     643     643       N6-acetyllysine (By similarity)   K  
end case

case <OC:Archaea>
From: EF2_SULSO (P30925)
Key     From     To       Description   Condition   FTGroup
NP_BIND     27     34       GTP (By similarity)      
NP_BIND     93     97       GTP (By similarity)      
NP_BIND     147     150       GTP (By similarity)      
MOD_RES     603     603       Diphthamide (By similarity)   H  
end case



Additional information


case <OC:Bacteria>
Size range: 669-715 amino acids
end case


case <OC:Archaea>
Size range: 726-743 amino acids
end case

Related UniRules: None
Template: P0A6M8 (EFG_ECOLI); P13551 (EFG_THETH); P30925 (EF2_SULSO): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in ANADE, BDEBA, BORA1, BORAP, BORBR, BORBU, BORGA, BORPA, BURCA, BURMA, BURPS, BURTA, BURXL, DESPS, GEOMG, GEOSL, HAHCH, METCA, MYXXD, PHOPR, POLSJ, PSEA6, PSEAE, PSEPK, RALME, RALSO, SACD2, SHEDO, SHEFN, SHEON, SHESM, SHESR, STRCO, SYNAS, SYNWW, SYNY3, TREDE, TREPA, TRIEI, VIBCH, VIBPA, VIBVY
Plasmid encoded: in RALME, RALSO
Comments: EFG2_BORBU could be made slightly longer in the N-terminal (MVVVGDL) by frameshifting just before the current initiator Met

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UniProtKB rule member sequences