AC   MF_00067;
DC   Protein; auto
TR   HAMAP; MF_00067; -; 1; level=0
XX
Names: GmhA
XX
ID   GMHA
case <OC:Bacteria>
DE   RecName: Full=Phosphoheptose isomerase;
DE            EC=5.3.1.28;
DE   AltName: Full=Sedoheptulose 7-phosphate isomerase;
end case
case <OC:Archaea>
DE   RecName: Full=Probable phosphoheptose isomerase;
DE            EC=5.3.1.28;
DE   AltName: Full=Sedoheptulose 7-phosphate isomerase;
end case
GN   Name=gmhA;
XX
CC   -!- FUNCTION: Catalyzes the isomerization of sedoheptulose 7-phosphate in
CC       D-glycero-D-manno-heptose 7-phosphate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-
CC         heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate;
CC         Xref=Rhea:RHEA:27489, ChEBI:CHEBI:57483, ChEBI:CHEBI:60203,
CC         ChEBI:CHEBI:60204; EC=5.3.1.28;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
CC   -!- PATHWAY: Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-
CC       phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and
CC       D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-
CC       phosphate: step 1/1.
case <OC:Pseudomonadota>
CC   -!- SUBUNIT: Homotetramer.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- MISCELLANEOUS: The reaction produces a racemic mixture of D-glycero-
CC       alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-
CC       phosphate.
CC   -!- SIMILARITY: Belongs to the SIS family. GmhA subfamily.
XX
DR   PROSITE; PS51464; SIS; 1; trigger=yes
DR   Pfam; PF01380; SIS; 1; trigger=no
DR   NCBIfam; TIGR00441; GmhA; 1; trigger=no
XX
KW   Cytoplasm
KW   Carbohydrate metabolism
KW   Isomerase
KW   Metal-binding
KW   Zinc
XX
GO   GO:0008270; F:zinc ion binding
GO   GO:0008968; F:D-sedoheptulose 7-phosphate isomerase activity
GO   GO:0005975; P:carbohydrate metabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: GMHA_BURPS (Q93UJ2)
FT   BINDING         55..57
FT                   /ligand="substrate"
FT   Condition: N-x-G
FT   BINDING         97..98
FT                   /ligand="substrate"
FT   Condition: N-D
FT   BINDING         123..125
FT                   /ligand="substrate"
FT   Condition: [ST]-T-S
FT   BINDING         64
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         68
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: [EQN]
FT   BINDING         175
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: [QH]
FT   BINDING         183
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         68
FT                   /ligand="substrate"
FT   Condition: [EQN]
FT   BINDING         128
FT                   /ligand="substrate"
FT   Condition: S
FT   BINDING         175
FT                   /ligand="substrate"
FT   Condition: [QH]
XX
Size: 182-231;
Related: None;
Template: P63224; Q93UJ2; Q9HVZ0; Q9AGY7;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in CAMJE
Plasmid: None
Comments: None
XX
# Revision 1.32 2023/06/01
//