AC   MF_00069;
DC   Protein; auto
TR   HAMAP; MF_00069; -; 1; level=0
XX
Names: Hydroxylam_reduct
XX
ID   HCP
DE   RecName: Full=Hydroxylamine reductase;
DE            EC=1.7.99.1;
DE   AltName: Full=Hybrid-cluster protein;
DE            Short=HCP;
DE   AltName: Full=Prismane protein;
GN   Name=hcp;
XX
CC   -!- FUNCTION: Catalyzes the reduction of hydroxylamine to form NH(3) and
CC       H(2)O.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine;
CC         Xref=Rhea:RHEA:22052, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15429, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:28938; EC=1.7.99.1;
case <OC:Gammaproteobacteria> and <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC       Note=Binds 1 [2Fe-2S] cluster.;
end case
case not <OC:Gammaproteobacteria> and <FTGroup:2>
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster.;
end case
case <FTGroup:3>
CC   -!- COFACTOR:
CC       Name=hybrid [4Fe-2O-2S] cluster; Xref=ChEBI:CHEBI:60519;
CC       Note=Binds 1 hybrid [4Fe-2O-2S] cluster.;
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the HCP family.
XX
DR   Pfam; PF03063; Prismane; 1; trigger=no
DR   NCBIfam; TIGR01703; hybrid_clust; 1; trigger=no
XX
KW   Cytoplasm
KW   Oxidoreductase
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
KW   Metal-binding
KW   Iron
KW   Iron-sulfur
end case
case <OC:Gammaproteobacteria> and <FTGroup:1>
KW   2Fe-2S
end case
case not <OC:Gammaproteobacteria> and <FTGroup:2>
KW   4Fe-4S
end case
XX
GO   GO:0005737; C:cytoplasm
GO   GO:0050418; F:hydroxylamine reductase activity
GO   GO:0051536; F:iron-sulfur cluster binding
XX
FT   From: HCP_ECOLI (P75825)
case <OC:Gammaproteobacteria>
FT   BINDING         3
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Group: 1; Condition: C
FT   BINDING         6
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Group: 1; Condition: C
FT   BINDING         18
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Group: 1; Condition: C
FT   BINDING         25
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Group: 1; Condition: C
end case
FT   From: HCP_DESVH (P31101)
case not <OC:Gammaproteobacteria>
FT   BINDING         3
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 2; Condition: C
FT   BINDING         6
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 2; Condition: C
FT   BINDING         15
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 2; Condition: C
FT   BINDING         21
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 2; Condition: C
end case
FT   BINDING         244
FT                   /ligand="hybrid [4Fe-2O-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:60519"
FT   Group: 3; Condition: H
FT   BINDING         268
FT                   /ligand="hybrid [4Fe-2O-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:60519"
FT   Group: 3; Condition: E
FT   BINDING         312
FT                   /ligand="hybrid [4Fe-2O-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:60519"
FT   Group: 3; Condition: C
FT   BINDING         406
FT                   /ligand="hybrid [4Fe-2O-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:60519"
FT                   /note="via persulfide group"
FT   Group: 3; Condition: C
FT   BINDING         434
FT                   /ligand="hybrid [4Fe-2O-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:60519"
FT   Group: 3; Condition: C
FT   BINDING         459
FT                   /ligand="hybrid [4Fe-2O-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:60519"
FT   Group: 3; Condition: C
FT   BINDING         494
FT                   /ligand="hybrid [4Fe-2O-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:60519"
FT   Group: 3; Condition: E
FT   BINDING         496
FT                   /ligand="hybrid [4Fe-2O-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:60519"
FT   Group: 3; Condition: K
FT   MOD_RES         406
FT                   /note="Cysteine persulfide"
FT   Condition: C
XX
Size: 427-570;
Related: None;
Template: P31101; Q01770; P75825; Q6WRT6;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in CLOAB
Plasmid: in ACIFR
Comments: Possible wrong start in THEMA and ACIFR.
 Deleted domain in THEMA/METTH.
XX
# Revision 1.42 2023/06/01
//