AC MF_00131; DC Protein; auto TR HAMAP; MF_00131; -; 1; level=0 XX Names: Trp_synth_alpha XX ID TRPA DE RecName: Full=Tryptophan synthase alpha chain; DE EC=4.2.1.20; GN Name=trpA; XX CC -!- FUNCTION: The alpha subunit is responsible for the aldol cleavage of CC indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. CC -!- CATALYTIC ACTIVITY: CC Reaction=(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- CC glyceraldehyde 3-phosphate + H2O + L-tryptophan; CC Xref=Rhea:RHEA:10532, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, CC ChEBI:CHEBI:57912, ChEBI:CHEBI:58866, ChEBI:CHEBI:59776; EC=4.2.1.20; CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L- CC tryptophan from chorismate: step 5/5. CC -!- SUBUNIT: Tetramer of two alpha and two beta chains. case CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast. end case CC -!- SIMILARITY: Belongs to the TrpA family. XX DR Pfam; PF00290; Trp_syntA; 1; trigger=no DR NCBIfam; TIGR00262; TrpA; 1; trigger=no DR PROSITE; PS00167; TRP_SYNTHASE_ALPHA; 1; trigger=no XX KW Amino-acid biosynthesis KW Aromatic amino acid biosynthesis KW Tryptophan biosynthesis KW Lyase XX GO GO:0004834; F:tryptophan synthase activity GO GO:0000162; P:tryptophan biosynthetic process case GO GO:0009507; C:chloroplast end case XX FT From: TRPA_ECOLI (P0A877) FT ACT_SITE 49 FT /note="Proton acceptor" FT Condition: E FT ACT_SITE 60 FT /note="Proton acceptor" FT Condition: [DE] XX Size: 239-293; Related: None; Template: P0A877; P00929; Q8U094; Scope: Bacteria Archaea Plastid Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: Highly divergent CHLTR; sequence not included in alignment XX # Revision 1.41 2023/06/01 //