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HAMAP annotation rule: MF_00147
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General rule information

Accession MF_00147
Dates 1-JUN-2001 (Created)
13-MAR-2012 (Last updated, Version 35)
Data class Protein

case <OC:Bacteria>
Predictors HAMAP; MF_00147_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00147_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_00147_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00147_A]
end case

Names TIM


Propagated annotation

Identifier, protein and gene names
Identifier TPIS
Protein name
RecName: Full=Triosephosphate isomerase;
Short=TIM;
EC=5.3.1.1;
AltName: Full=Triose-phosphate isomerase;
Gene name tpiA
Comments
CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone phosphate.
PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.

case <OC:Pyrococcus> or <OC:Thermoproteus> or <OC:Methanocaldococcus>
SUBUNIT: Homotetramer (By similarity).
end case


case not <OC:Pyrococcus> or <OC:Thermoproteus>
SUBUNIT: Homodimer (By similarity).
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the triosephosphate isomerase family.
Cross-references
Pfam PF00121; TIM; 1;
TIGRFAMs TIGR00419; Tim; 1;
PROSITE PS00171; TIM_1; 1;
Keywords
Cytoplasm, Isomerase, Glycolysis, Gluconeogenesis, Pentose shunt.

case <FT:5>
Phosphoprotein.
end case

Gene Ontology
GO:0004807; Molecular function: triose-phosphate isomerase activity.
GO:0006094; Biological process: gluconeogenesis.
GO:0006096; Biological process: glycolysis.
GO:0006098; Biological process: pentose-phosphate shunt.
GO:0005737; Cellular component: cytoplasm.
Features

case <OC:Bacteria>
From: TPIS_ECOLI (P0A858)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     95     95       Electrophile (By similarity)   H  
ACT_SITE     167     167       Proton acceptor (By similarity)   E  
BINDING     9     9       Substrate (By similarity)   N  
BINDING     11     11       Substrate (By similarity)   K  
end case

case <OC:Bacillaceae>
From: TPIS_BACSU (P27876)
Key     From     To       Description   Condition   FTGroup
MOD_RES     213     213       Phosphoserine (By similarity)   S  
end case

case <OC:Archaea>
From: TPIS_PYRWO (P62003)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     96     96       Electrophile (By similarity)   H  
ACT_SITE     144     144       Proton acceptor (By similarity)   E  
BINDING     12     12       Substrate (By similarity)   N  
BINDING     14     14       Substrate (By similarity)   K  
end case



Additional information


case <OC:Bacteria>
Size range: 223-293 amino acids
end case


case <OC:Archaea>
Size range: 213-231 amino acids
end case

Related UniRules: None
Template: P00943 (TPIS_GEOSE); P0A858 (TPIS_ECOLI); P50921 (TPIS_VIBMA); O74025 (TPIS_METBR); P62003 (TPIS_PYRWO); P36204 (PGKT_THEMA); Q58923 (TPIS_METJA); Q8NKN9 (TPIS_THETK): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: MF_00145 (pgk); Cter: None
Duplicate: in BRUME, BRUSU, LISIN, LISMO, RHILO, RHIME
Plasmid encoded: None
Comments: Probable wrong start in CHLTR

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UniProtKB rule member sequences