AC MF_00152; DC Protein; auto TR HAMAP; MF_00152; -; 1; level=0 XX Names: Nfo XX ID END4 DE RecName: Full=Probable endonuclease 4; DE EC=3.1.21.2; DE AltName: Full=Endodeoxyribonuclease IV; DE AltName: Full=Endonuclease IV; GN Name=nfo; XX CC -!- FUNCTION: Endonuclease IV plays a role in DNA repair. It cleaves CC phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating CC a 3'-hydroxyl group and a 5'-terminal sugar phosphate. CC -!- CATALYTIC ACTIVITY: CC Reaction=Endonucleolytic cleavage to 5'-phosphooligonucleotide end- CC products.; EC=3.1.21.2; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Note=Binds 3 Zn(2+) ions.; CC -!- SIMILARITY: Belongs to the AP endonuclease 2 family. XX DR Pfam; PF01261; AP_endonuc_2; 1; trigger=no DR NCBIfam; TIGR00587; Nfo; 1; trigger=no DR PROSITE; PS00729; AP_NUCLEASE_F2_1; 1; trigger=no DR PROSITE; PS00730; AP_NUCLEASE_F2_2; 1; trigger=no DR PROSITE; PS00731; AP_NUCLEASE_F2_3; 1; trigger=no DR PROSITE; PS51432; AP_NUCLEASE_F2_4; 1; trigger=no XX KW Hydrolase KW Nuclease KW Endonuclease KW DNA damage KW DNA repair KW Metal-binding KW Zinc XX GO GO:0008833; F:deoxyribonuclease IV (phage-T4-induced) activity GO GO:0008270; F:zinc ion binding GO GO:0006281; P:DNA repair XX FT From: END4_ECOLI (P0A6C1) FT BINDING 69 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT Condition: H FT BINDING 109 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT Condition: H FT BINDING 145 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT Condition: E FT BINDING 145 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT Condition: E FT BINDING 179 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT Condition: D FT BINDING 182 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="3" FT Condition: H FT BINDING 216 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT Condition: H FT BINDING 229 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="3" FT Condition: D FT BINDING 231 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="3" FT Condition: H FT BINDING 261 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT Condition: E XX Size: 252-310; Related: None; Template: P0A6C1; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.32 2023/06/01 //