AC   MF_00207;
DC   Protein; auto
TR   HAMAP; MF_00207; -; 1; level=0
XX
Names: PPase_C
XX
ID   PPAC
DE   RecName: Full=Probable manganese-dependent inorganic pyrophosphatase;
DE            EC=3.6.1.1;
DE   AltName: Full=Pyrophosphate phospho-hydrolase;
DE            Short=PPase;
GN   Name=ppaC;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:43474; EC=3.6.1.1;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Note=Binds 2 manganese ions per subunit.;
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the PPase class C family.
XX
DR   Pfam; PF01368; DHH; 1; trigger=no
DR   Pfam; PF02833; DHHA2; 1; trigger=no
XX
KW   Cytoplasm
KW   Hydrolase
case <FTGroup:1>
KW   Manganese
KW   Metal-binding
end case
XX
GO   GO:0004427; F:inorganic diphosphate phosphatase activity
GO   GO:0030145; F:manganese ion binding
GO   GO:0005737; C:cytoplasm
XX
FT   From: PPAC_BACSU (P37487)
FT   BINDING         9
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Group: 1; Condition: H
FT   BINDING         13
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Group: 1; Condition: D
FT   BINDING         15
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Group: 1; Condition: D
FT   BINDING         75
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Group: 1; Condition: D
FT   BINDING         75
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Group: 1; Condition: D
FT   BINDING         97
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Group: 1; Condition: H
FT   BINDING         149
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Group: 1; Condition: D
XX
Size: 307-336;
Related: None;
Template: P37487; Q58025;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: The sequence of ppaC in THEMA is interrupted by a 130-residue insert that
 contains 2 CBS domains.
XX
# Revision 1.26 2022/11/19
//