Annotation rule MF_00220
Send feedback

General rule information [?]

Accession MF_00220
Dates 1-JUN-2001 (Created)
19-MAY-2011 (Last updated, Version 32)
Name PyrC_type2
Scope Bacteria
Archaea
case <OC:Bacteria>
end case

case <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PYRC
Protein name
RecName: Full=Dihydroorotase;
Short=DHOase;
EC=3.5.2.3;
Gene name
pyrC

Comments [?]

Catalytic activity (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.
Cofactor Binds 2 zinc ions per subunit (By similarity).
Pathway Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate; step 3/3.
Subunit Homodimer (By similarity).
Similarity Belongs to the DHOase family. Type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004151; Molecular function: dihydroorotase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.

Cross-references [?]

Pfam PF01979; Amidohydro_1; 1;
TIGRFAMs TIGR00857; PyrC_multi; 1;
PROSITE PS00482; DIHYDROOROTASE_1; 1;
PS00483; DIHYDROOROTASE_2; 1;

Features [?]

case <OC:Bacteria>
From: PYRC_BACSU (P25995)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     59     59       Zinc 1 (By similarity)     H  
METAL     61     61       Zinc 1 (By similarity)     H  
METAL     141     141       Zinc 1; via carbamate group (By similarity)     K  
METAL     141     141       Zinc 2; via carbamate group (By similarity)     K  
METAL     178     178       Zinc 2 (By similarity)     H  
METAL     231     231       Zinc 2 (By similarity)     H  
METAL     304     304       Zinc 1 (By similarity)     D  
MOD_RES     141     141       N6-carboxylysine (By similarity)     K  
end case
case <OC:Archaea>
From: PYRC_PYRAB (Q9UXV6)
METAL     57     57       Zinc 1 (By similarity)     H  
METAL     59     59       Zinc 1 (By similarity)     H  
METAL     130     130       Zinc 1; via carbamate group (By similarity)     K  
METAL     130     130       Zinc 2; via carbamate group (By similarity)     K  
METAL     164     164       Zinc 2 (By similarity)     H  
METAL     204     204       Zinc 2 (By similarity)     H  
METAL     272     272       Zinc 1 (By similarity)     D  
MOD_RES     130     130       N6-carboxylysine (By similarity)     K  
end case

Additional information [?]

case <OC:Bacteria>
Size range 376-447 amino acids
end case
case <OC:Archaea>
Size range 383-467 amino acids
end case
Related rules MF_00219 (PYRC)
Template P25995 (PYRC_BACSU)
Fusion None