HAMAP

Accession	MF_00253
Dates	1-JUN-2001 (Created) 21-NOV-2011 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00253_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00253_B]

Predictors

HAMAP; MF_00253_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00253_A]

Names

Gly_tRNA_synth

Identifier

SYG

Protein name

RecName: Full=Glycine--tRNA ligase; EC=6.1.1.14; AltName: Full=Glycyl-tRNA synthetase; Short=GlyRS;

Gene name

glyQS

Gene name

glyS

FUNCTION: Catalyzes the attachment of glycine to tRNA(Gly) (By similarity).

CATALYTIC ACTIVITY: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.

Pfam	PF00587; tRNA-synt_2b; 1;
PRINTS	PR01043; TRNASYNTHGLY; 1;
TIGRFAMs	TIGR00389; GlyS_dimeric; 1;
PROSITE	PS50862; AA_TRNA_LIGASE_II; 1;

Cytoplasm, Aminoacyl-tRNA synthetase, Protein biosynthesis, Ligase, ATP-binding, Nucleotide-binding.

GO:0005524; Molecular function: ATP binding.
GO:0004820; Molecular function: glycine-tRNA ligase activity.
GO:0006426; Biological process: glycyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

From: SYG_THET8 (P56206)
Key		From		To		Description		Condition		FTGroup
NP_BIND		221		223		ATP (By similarity)		R-N-E
NP_BIND		231		236		ATP (By similarity)		[FILV]-R-x(3)-[FL]
NP_BIND		305		306		ATP (By similarity)		E-[CILV]
NP_BIND		364		367		ATP (By similarity)		G-x(2)-R
REGION		236		240		Substrate binding (By similarity)		[FL]-x-Q-x-E
REGION		360		364		Substrate binding (By similarity)		E-x(3)-G
BINDING		99		99		Substrate (By similarity)		[KR]
BINDING		189		189		Substrate (By similarity)		E

From: SYG_METJA (Q57681)
Key		From		To		Description		Condition		FTGroup
NP_BIND		196		198		ATP (By similarity)		R-N-E
NP_BIND		206		211		ATP (By similarity)		[FILV]-R-x(3)-F
NP_BIND		328		329		ATP (By similarity)		E-[CILV]
NP_BIND		451		454		ATP (By similarity)		G-x(2)-R
REGION		211		215		Substrate binding (By similarity)		F-x(3)-E
REGION		447		451		Substrate binding (By similarity)		E-x(3)-G
BINDING		98		98		Substrate (By similarity)		R
BINDING		164		164		Substrate (By similarity)		E

Size range:

445-506 amino acids

Size range:

565-583 amino acids

Related UniRules:	None
Template:	P56206 (SYG_THET8)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None