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Annotation rule MF_00253
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General rule information [?]

Accession MF_00253
Dates 1-JUN-2001 (Created)
26-SEP-2014 (Last updated, Version 25)
Name Gly_tRNA_synth
Scope Bacteria
Archaea
Template P56206 (SYG_THET8)
case <OC:Bacteria>
end case

case <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SYG
Protein name
RecName: Full=Glycine--tRNA ligase;
EC=6.1.1.14;
AltName: Full=Glycyl-tRNA synthetase;
Short=GlyRS;
case <OC:Bacteria>
Gene name
glyQS
end case
case <OC:Archaea>
Gene name
glyS
end case

Comments [?]

Function Catalyzes the attachment of glycine to tRNA(Gly).
Catalytic activity ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
case <OC:Bacteria>
Subunit Homodimer.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the class-II aminoacyl-tRNA synthetase family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004820; Molecular function: glycine-tRNA ligase activity.
GO:0006426; Biological process: glycyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00587; tRNA-synt_2b; 1;
PRINTS PR01043; TRNASYNTHGLY; 1;
TIGRFAMs TIGR00389; GlyS_dimeric; 1;
PROSITE PS50862; AA_TRNA_LIGASE_II; 1;

Features [?]

case <OC:Bacteria>
From: SYG_THET8 (P56206)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     221     223       ATP     R-N-E  
NP_BIND     231     236       ATP     [FILV]-R-x(3)-[FL]  
NP_BIND     305     306       ATP     E-[CILV]  
NP_BIND     364     367       ATP     G-x(2)-R  
REGION     236     240       Substrate binding     [FL]-x-Q-x-E  
REGION     360     364       Substrate binding     E-x(3)-G  
BINDING     99     99       Substrate     [KR]  
BINDING     189     189       Substrate     E  
end case
case <OC:Archaea>
From: SYG_METJA (Q57681)
NP_BIND     196     198       ATP     R-N-E  
NP_BIND     206     211       ATP     [FILV]-R-x(3)-F  
NP_BIND     328     329       ATP     E-[CILV]  
NP_BIND     451     454       ATP     G-x(2)-R  
REGION     211     215       Substrate binding     F-x(3)-E  
REGION     447     451       Substrate binding     E-x(3)-G  
BINDING     98     98       Substrate     R  
BINDING     164     164       Substrate     E  
end case

Additional information [?]

case <OC:Bacteria>
Size range 445-506 amino acids
end case
case <OC:Archaea>
Size range 565-583 amino acids
end case
Related rules None
Fusion None