AC MF_00290; DC Protein; auto TR HAMAP; MF_00290; -; 1; level=0 XX Names: tRNA_dimethyltr_TRM1 XX ID TRM1 case DE RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase; DE EC=2.1.1.216; DE AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase; DE AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase; DE AltName: Full=tRNA(m(2,2)G26)dimethyltransferase; end case case DE RecName: Full=tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase; DE EC=2.1.1.215; end case GN Name=trm1; XX case CC -!- FUNCTION: Dimethylates a single guanine residue at position 26 of a CC number of tRNAs using S-adenosyl-L-methionine as donor of the methyl CC groups. CC -!- CATALYTIC ACTIVITY: CC Reaction=guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + CC N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine; CC Xref=Rhea:RHEA:43140, Rhea:RHEA-COMP:10359, Rhea:RHEA-COMP:10360, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, CC ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.216; end case case CC -!- FUNCTION: Dimethylates the guanine residues at position 26 and 27 of CC one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl CC groups. CC -!- CATALYTIC ACTIVITY: CC Reaction=guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L- CC methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)- CC dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine; CC Xref=Rhea:RHEA:43136, Rhea:RHEA-COMP:10353, Rhea:RHEA-COMP:10354, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, CC ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.215; end case CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase CC superfamily. Trm1 family. XX DR Pfam; PF02005; TRM; 1; trigger=no DR NCBIfam; TIGR00308; TRM1; 1; trigger=no DR PROSITE; PS51626; SAM_MT_TRM1; 1; trigger=yes XX KW Methyltransferase KW S-adenosyl-L-methionine KW Transferase KW tRNA processing XX GO GO:0160104; F:tRNA (guanine(26)-N2)-dimethyltransferase activity GO GO:0030488; P:tRNA methylation XX FT None XX Size: 340-420; Related: None; Template: P81554; O67010; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.24 2023/12/15 //