AC MF_00387; DC Protein; auto TR HAMAP; MF_00387; -; 1; level=0 XX Names: LpxA XX ID LPXA DE RecName: Full=Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; DE Short=UDP-N-acetylglucosamine acyltransferase; DE EC=2.3.1.129; GN Name=lpxA; XX case not CC -!- FUNCTION: Involved in the biosynthesis of lipid A, a phosphorylated CC glycolipid that anchors the lipopolysaccharide to the outer membrane of CC the cell. end case case CC -!- FUNCTION: Involved in the biosynthesis of lipid A, a phosphorylated CC glycolipid that in bacteria anchors the lipopolysaccharide to the outer CC membrane of the cell. The target for the lipopolysaccharides produced CC in the chloroplast could either be the cell envelope of the eukaryote CC or the plastid membrane. end case CC -!- CATALYTIC ACTIVITY: CC Reaction=a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = CC a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo- CC [ACP]; Xref=Rhea:RHEA:67812, Rhea:RHEA-COMP:9685, Rhea:RHEA- CC COMP:9945, ChEBI:CHEBI:57705, ChEBI:CHEBI:64479, ChEBI:CHEBI:78827, CC ChEBI:CHEBI:173225; EC=2.3.1.129; CC -!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) CC from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- CC acetyl-alpha-D-glucosamine: step 1/6. CC -!- SUBUNIT: Homotrimer. case CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast. else CC -!- SUBCELLULAR LOCATION: Cytoplasm. end case CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family. LpxA CC subfamily. XX DR Pfam; PF00132; Hexapep; 5-8; trigger=no DR PIRSF; PIRSF000456; UDP-GlcNAc_acltr; 1; trigger=no DR NCBIfam; TIGR01852; Lipid_A_lpxA; 1; trigger=no DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1; trigger=no XX case not KW Cytoplasm end case KW Acyltransferase KW Lipid A biosynthesis KW Lipid biosynthesis KW Lipid metabolism KW Repeat KW Transferase XX GO GO:0008780; F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity GO GO:0009245; P:lipid A biosynthetic process case GO GO:0009507; C:chloroplast else GO GO:0005737; C:cytoplasm end case XX FT None XX Size: 257-283; Related: MF_00523; Template: P0A722; P32199; Scope: Bacteria Plastid Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.36 2023/06/01 //