AC   MF_00394;
DC   Protein; auto
TR   HAMAP; MF_00394; -; 1; level=0
XX
Names: NAD_Glyc3P_dehydrog
XX
ID   GPDA
DE   RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(P)+];
DE            EC=1.1.1.94;
DE   AltName: Full=NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
GN   Name=gpsA;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate
CC         + H(+) + NADH; Xref=Rhea:RHEA:11092, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642,
CC         ChEBI:CHEBI:57945; EC=1.1.1.94;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate
CC         + H(+) + NADPH; Xref=Rhea:RHEA:11096, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349; EC=1.1.1.94;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- PATHWAY: Membrane lipid metabolism; glycerophospholipid metabolism.
CC   -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate
CC       dehydrogenase family.
XX
DR   Pfam; PF07479; NAD_Gly3P_dh_C; 1; trigger=no
DR   Pfam; PF01210; NAD_Gly3P_dh_N; 1; trigger=no
DR   PIRSF; PIRSF000114; Glycerol-3-P_dh; 1; trigger=no
DR   PRINTS; PR00077; GPDHDRGNASE; 1; trigger=no
DR   PROSITE; PS00957; NAD_G3PDH; 1; trigger=no
XX
KW   Cytoplasm
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Phospholipid biosynthesis
KW   Phospholipid metabolism
KW   NAD
KW   Oxidoreductase
XX
GO   GO:0047952; F:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO   GO:0046167; P:glycerol-3-phosphate biosynthetic process
GO   GO:0008654; P:phospholipid biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: GPDA_ECOLI (P0A6S7)
FT   BINDING         12..17
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   BINDING         259..260
FT                   /ligand="substrate"
FT   Condition: R-N
FT   ACT_SITE        195
FT                   /note="Proton acceptor"
FT   Condition: K
FT   BINDING         110
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: K
FT   BINDING         110
FT                   /ligand="substrate"
FT   Condition: K
FT   BINDING         143
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [AS]
FT   BINDING         259
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: R
FT   BINDING         285
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: E
XX
Size: 297-369;
Related: None;
Template: O29390;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in MYCPA, MYCTU
Plasmid: None
Comments: None
XX
# Revision 1.37 2022/11/19
//