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HAMAP annotation rule: MF_00400
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General rule information

Accession MF_00400
Dates 1-JUN-2001 (Created)
7-OCT-2011 (Last updated, Version 34)
Data class Protein
Predictors HAMAP; MF_00400; [distribution of match scores in UniProtKB];[seed alignment for MF_00400]
Names MdtK


Propagated annotation

Identifier, protein and gene names
Identifier MDTK
Protein name
RecName: Full=Multidrug resistance protein MdtK;
AltName: Full=Multidrug-efflux transporter;
Gene name mdtK
Comments
FUNCTION: Multidrug efflux pump that functions probably as a Na(+)/drug antiporter (By similarity).

case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case

SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
Cross-references
Pfam PF01554; MatE; 2;
TIGRFAMs TIGR00797; MatE; 1;
General Transmembrane; -; 12; trigger=Yes;
Keywords
Antiport.

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case

Cell membrane, Ion transport, Membrane, Sodium, Sodium transport, Transmembrane, Transport, Transmembrane helix.
Gene Ontology
GO:0015297; Molecular function: antiporter activity.
GO:0015238; Molecular function: drug transmembrane transporter activity.
GO:0006855; Biological process: drug transmembrane transport.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.


Additional information

Size range: 457-457 amino acids
Related UniRules: None
Template: P37340 (MDTK_ECOLI); Q7WTR3 (MDTK_ERWAM): [Recover all]
Scope: Bacteria; Enterobacteriaceae
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences