AC   MF_00496;
DC   Protein; auto
TR   HAMAP; MF_00496; -; 1; level=0
XX
Names: F6P_aldolase
XX
ID   FSA
case <OC:Enterobacterales>
DE   RecName: Full=Fructose-6-phosphate aldolase;
DE            EC=4.1.2.-;
else
DE   RecName: Full=Probable fructose-6-phosphate aldolase;
DE            EC=4.1.2.-;
end case
GN   Name=fsa;
XX
CC   -!- FUNCTION: Catalyzes the reversible formation of fructose 6-phosphate
CC       from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an
CC       aldolization reaction.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 6-phosphate = dihydroxyacetone + D-
CC         glyceraldehyde 3-phosphate; Xref=Rhea:RHEA:28002, ChEBI:CHEBI:16016,
CC         ChEBI:CHEBI:57634, ChEBI:CHEBI:59776;
case <OC:Enterobacterales>
CC   -!- SUBUNIT: Homodecamer.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the transaldolase family. Type 3A subfamily.
XX
DR   Pfam; PF00923; TAL_FSA; 1; trigger=no
DR   NCBIfam; TIGR00875; fsa_talC_mipB; 1; trigger=no
DR   PROSITE; PS01054; TRANSALDOLASE_1; 1; trigger=no
DR   PROSITE; PS00958; TRANSALDOLASE_2; 1; trigger=no
XX
KW   Carbohydrate metabolism
KW   Cytoplasm
KW   Lyase
KW   Schiff base
XX
GO   GO:0016832; F:aldehyde-lyase activity
GO   GO:0006000; P:fructose metabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: FSAA_ECOLI (P78055)
FT   ACT_SITE        85
FT                   /note="Nucleophile; Schiff-base intermediate with
FT                   substrate"
FT   Condition: K
FT   ACT_SITE        131
FT                   /note="Proton donor/acceptor"
FT   Condition: Y
XX
Size: 210-230;
Related: MF_00492; MF_00493; MF_00494;
Template: P78055; P32669;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in ECO57, ECOLI
Plasmid: None
Comments: None
XX
# Version: 20
# Last updated date: 2025-11-26
# Created date: 2005-02-28
//