HAMAP rule MF_00704
General rule information
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Accession | MF_00704 |
Dates | 27-AUG-2003 (Created)
17-FEB-2023 (Last updated, Version 21) |
Name | Aspartoacylase |
Scope(s) |
Bacteria Cyanobacteriota |
Template(s) | P45381 (ACY2_HUMAN); [ Recover all ] |
Triggered by |
HAMAP; MF_00704 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ASPA |
Protein name | RecName: Full=Probable aspartoacylase; EC=3.5.1.15; |
Comments
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CATALYTIC ACTIVITY | Reaction=H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate; Xref=Rhea:RHEA:10872, ChEBI:CHEBI:15377, ChEBI:CHEBI:29067, ChEBI:CHEBI:29991, ChEBI:CHEBI:58497; EC=3.5.1.15; |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
SIMILARITY | Belongs to the AspA/AstE family. Aspartoacylase subfamily. |
Keywords
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Hydrolase | |
case <FTGroup:1> | |
Metal-binding | |
Zinc | |
end case |
Gene Ontology
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case <FTGroup:1> | |
GO:0008270; Molecular function:zinc ion binding | |
end case | |
GO:0019807; Molecular function:aspartoacylase activity |
Cross-references
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Pfam | PF04952; AstE_AspA; 1; |
PIRSF | PIRSF018001; Aspartoacylase; 1; |
Features
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From: ASPA_NOSS1 (Q8YQC1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 63 | 64 | /ligand="substrate" | N-R | ||||||||
BINDING | 14 | 14 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
BINDING | 17 | 17 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
E | 1 | |||||||
BINDING | 106 | 106 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
BINDING | 56 | 56 | /ligand="substrate" | R | ||||||||
BINDING | 164 | 164 | /ligand="substrate" | E | ||||||||
BINDING | 275 | 275 | /ligand="substrate" | Y |
Additional information
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Size range | 288-307 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |