AC   MF_01006;
DC   Protein; auto
TR   HAMAP; MF_01006; -; 1; level=0
XX
Names: Undec_diphosphatase
XX
ID   UPPP
case <OC:Bacteria>
DE   RecName: Full=Undecaprenyl-diphosphatase;
DE            EC=3.6.1.27;
DE   AltName: Full=Bacitracin resistance protein;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase;
end case
case <OC:Archaea>
DE   RecName: Full=Undecaprenyl-diphosphatase;
DE            EC=3.6.1.27;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase;
end case
GN   Name=uppP;
XX
case <OC:Bacteria>
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl diphosphate
CC       (UPP). Confers resistance to bacitracin.
end case
case <OC:Archaea>
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl diphosphate
CC       (UPP).
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-
CC         trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate;
CC         Xref=Rhea:RHEA:28094, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58405, ChEBI:CHEBI:60392; EC=3.6.1.27;
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
case <OC:Bacteria>
CC   -!- MISCELLANEOUS: Bacitracin is thought to be involved in the inhibition
CC       of peptidoglycan synthesis by sequestering undecaprenyl diphosphate,
CC       thereby reducing the pool of lipid carrier available.
end case
CC   -!- SIMILARITY: Belongs to the UppP family.
XX
DR   Pfam; PF02673; BacA; 1; trigger=no
DR   NCBIfam; TIGR00753; Undec_PP_bacA; 1; trigger=no
DR   General; Transmembrane; -; 5-9; trigger=yes
XX
case <OC:Bacteria>
KW   Antibiotic resistance
KW   Cell shape
KW   Cell wall biogenesis/degradation
end case
KW   Hydrolase
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
case <OC:Bacteria>
KW   Peptidoglycan synthesis
end case
KW   Cell membrane
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0050380; F:undecaprenyl-diphosphatase activity
case <OC:Bacteria>
GO   GO:0046677; P:response to antibiotic
end case
GO   GO:0005886; C:plasma membrane
XX
FT   None
XX
Size: 237-343;
Related: None;
Template: P60932; P60934;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in ACIAD, AGRFC, BACAH, BACAN, BACC1, BACCR, BACCZ, HALH5, BACHK,
 BACLD, SHOC1, BURO1, BURCH, BURCM, BURP0, BURP1, BURPS, BURL3, BURTA, PARXL,
 CHRVO, CLOAB, CLOD6, CORJK, ENTFA, FRAAA, FRACC, MAGSA, OENOB, PSET1, PSEPF,
 STUS1, RHILO, RHORT, SHEON, STRAW, STRCO
Plasmid: in CORST, ENTFA
Comments: UPPP2 from RHILO is shorter but can not easily be extended.
XX
# Revision 1.59 2023/11/29
//