AC   MF_01109;
DC   Protein; auto
TR   HAMAP; MF_01109; -; 1; level=0
XX
Names: OTCase
XX
case defined <Property:ARGININE_BS> and not <Property:ARGININE_BS>
ID   OTCC
DE   RecName: Full=Ornithine carbamoyltransferase, catabolic;
DE            Short=OTCase;
DE            EC=2.1.3.3;
else
ID   OTC
DE   RecName: Full=Ornithine carbamoyltransferase;
DE            Short=OTCase;
DE            EC=2.1.3.3;
end case
case <Property:ARGININE_BS> and <OC:Enterobacterales>
GN   Name=argI;
end case
case <Property:ARGININE_BS> and not <OC:Enterobacterales>
GN   Name=argF;
end case
case not <Property:ARGININE_BS>
GN   Name=arcB;
end case
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + L-ornithine = H(+) + L-citrulline +
CC         phosphate; Xref=Rhea:RHEA:19513, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:46911, ChEBI:CHEBI:57743,
CC         ChEBI:CHEBI:58228; EC=2.1.3.3;
case <Property:ARGININE_BS>
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 1/3.
end case
case not <Property:ARGININE_BS>
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 2/2.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. OTCase family.
XX
DR   Pfam; PF00185; OTCace; 1; trigger=no
DR   Pfam; PF02729; OTCace_N; 1; trigger=no
DR   PRINTS; PR00100; AOTCASE; 1; trigger=no
DR   NCBIfam; TIGR00658; Orni_carb_tr; 1; trigger=no
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1; trigger=no
XX
case <Property:ARGININE_BS>
KW   Amino-acid biosynthesis
KW   Arginine biosynthesis
end case
case not <Property:ARGININE_BS>
KW   Arginine metabolism
end case
KW   Cytoplasm
KW   Transferase
XX
GO   GO:0004585; F:ornithine carbamoyltransferase activity
case <Property:ARGININE_BS>
GO   GO:0006526; P:arginine biosynthetic process
end case
case not <Property:ARGININE_BS>
GO   GO:0019546; P:arginine deiminase pathway
end case
GO   GO:0005737; C:cytoplasm
XX
FT   From: OTC1_ECOLI (P04391)
FT   BINDING         56..59
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT   Condition: S-[TS]-R-T
FT   BINDING         134..137
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT   Condition: H-x(2)-Q
FT   BINDING         236..237
FT                   /ligand="L-ornithine"
FT                   /ligand_id="ChEBI:CHEBI:46911"
FT   Condition: S-[MIL]
FT   BINDING         274..275
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT   Condition: C-L
FT   BINDING         83
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT   Condition: [QN]
FT   BINDING         107
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT   Condition: R
FT   BINDING         168
FT                   /ligand="L-ornithine"
FT                   /ligand_id="ChEBI:CHEBI:46911"
FT   Condition: N
FT   BINDING         232
FT                   /ligand="L-ornithine"
FT                   /ligand_id="ChEBI:CHEBI:46911"
FT   Condition: D
FT   BINDING         320
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT   Condition: [RK]
XX
Size: 295-354;
Related: MF_02102!;
Template: P04391; P9WIT9; Q8DCF5;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in ECOL6, LACLA, PSEAE, PSEPK, RHIME, SALTI, SALTY, STAAM, STAAN,
 STAAW, STAES, STRA3, STRA5
Plasmid: in HALSA, RHIME
Comments: OTCases can be involved in the biosynthesis of arginine and in
 its catabolism, by the arginine deiminase pathway. Some bacteria
 possess two distinct OTCases; some do not degrade arginine using this
 pathway and others do not synthesize arginine. As it is impossible to
 distinguish between anabolic and catabolic OTCases based on sequence
 similarity alone, if paralogs are found in a given genome, then one is
 probably the anabolic enzyme and the other the catabolic one, named
 arcB, which is usually located in the arcABC operon. E.coli K-12
 carries two genes for anabolic OTCase, argF and argI; their products
 interact to form a family of four trimeric isoenzymes. Only argI can be
 found in E.coli B, E.coli W or in other enterobacteria.
XX
# Revision 1.40 2023/06/01
//