AC   MF_01132;
DC   Protein; auto
TR   HAMAP; MF_01132; -; 1; level=0
XX
Names: Spx
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ID   SPX
DE   RecName: Full=Global transcriptional regulator Spx;
GN   Name=spx;
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CC   -!- FUNCTION: Global transcriptional regulator that plays a key role in
CC       stress response and exerts either positive or negative regulation of
CC       genes. Acts by interacting with the C-terminal domain of the alpha
CC       subunit of the RNA polymerase (RNAP). This interaction can enhance
CC       binding of RNAP to the promoter region of target genes and stimulate
CC       their transcription, or block interaction of RNAP with activator
CC   -!- SUBUNIT: Interacts with the C-terminal domain of the alpha subunit of
CC       the RNAP.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
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DR   Pfam; PF03960; ArsC; 1; trigger=no
DR   NCBIfam; TIGR01617; arsC_related; 1; trigger=no
DR   PROSITE; PS51353; ARSC; 1; trigger=yes
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KW   Cytoplasm
case <FT:1>
KW   Disulfide bond
KW   Redox-active center
end case
KW   Transcription
KW   Transcription regulation
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GO   GO:0006355; P:regulation of DNA-templated transcription
GO   GO:0005737; C:cytoplasm
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FT   From: SPX_BACSU (O31602)
FT   DISULFID        10..13
FT                   /note="Redox-active"
FT   Condition: C-x-x-C
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Size: 128-160;
Related: None;
Template: O31602; Q2G1U6;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAN, BACCR, LACLA, OCEIH
Plasmid: None
Comments: None
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# Revision 1.26 2023/06/01
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