AC MF_01143; DC Protein; auto TR HAMAP; MF_01143; -; 1; level=0 XX Names: CidA XX ID CIDA DE RecName: Full=Holin-like protein CidA; GN Name=cidA; XX case CC -!- FUNCTION: Increases the activity of extracellular murein hydrolases CC possibly by mediating their export via hole formation. Inhibited by the CC antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB CC products probably inhibit the function of the CidAB proteins. When a CC cell is stressed by the addition of antibiotics or by other factors in CC the environment, the CidAB proteins possibly oligomerize within the CC bacterial cell membrane, creating lesions that disrupt the proton CC motive force, which in turn results in loss of cell viability. These CC lesions are also hypothesized to regulate the subsequent cell lysis by CC either allowing the murein hydrolases access to the cell wall substrate CC and/or regulating their activity by a possible change in the cell wall CC pH that results from loss of membrane potential. else CC -!- FUNCTION: Increases the activity of extracellular murein hydrolases CC possibly by mediating their export via hole formation. Inhibited by the CC antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB CC products probably inhibit the function of the CidA protein. When a cell CC is stressed by the addition of antibiotics or by other factors in the CC environment, CidA possibly oligomerizes within the bacterial cell CC membrane, creating lesions that disrupt the proton motive force, which CC in turn results in loss of cell viability. These lesions are also CC hypothesized to regulate the subsequent cell lysis by either allowing CC the murein hydrolases access to the cell wall substrate and/or CC regulating their activity by a possible change in the cell wall pH that CC results from loss of membrane potential. end case CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the CidA/LrgA family. CidA subfamily. XX DR Pfam; PF03788; LrgA; 1; trigger=no DR General; Transmembrane; -; 4; trigger=yes XX KW Cell membrane KW Cytolysis KW Membrane KW Transmembrane KW Transmembrane helix XX GO GO:0019835; P:cytolysis GO GO:0012501; P:programmed cell death GO GO:0005886; C:plasma membrane XX FT None XX Size: 118-131; Related: None; Template: P60647; Scope: Bacteria; Bacillales Fusion: Nter: None Cter: None Duplicate: in BACAN, BACCR Plasmid: None Comments: None XX # Revision 1.18 2019/11/19 //