HAMAP rule MF_01163
General rule information
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| Accession | MF_01163 |
| Dates | 11-APR-2005 (Created)
19-NOV-2022 (Last updated, Version 21) |
| Name | IMP_biosynth_PurP |
| Scope(s) |
Archaea |
| Template(s) | Q57600 (PURP_METJA); Q8U0R7 (PURP_PYRFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01163 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PURP |
| Protein name | RecName: Full=5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase; EC=6.3.4.23; AltName: Full=5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase; |
| Gene name | Name=purP; |
Comments
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| FUNCTION | Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. |
| CATALYTIC ACTIVITY | Reaction=5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide + ADP + phosphate; Xref=Rhea:RHEA:24836, ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58467, ChEBI:CHEBI:58475, ChEBI:CHEBI:456216; EC=6.3.4.23; |
| PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino- 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1. |
| SIMILARITY | Belongs to the phosphohexose mutase family. |
Keywords
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Gene Ontology
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| GO:0016879; Molecular function:ligase activity, forming carbon-nitrogen bonds |
| GO:0006189; Biological process:'de novo' IMP biosynthetic process |
Cross-references
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Features
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| From: PURP_PYRFU (Q8U0R7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 204 | 204 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
E | ||||||||
| BINDING | 11 | 11 | /ligand="5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide" /ligand_id="ChEBI:CHEBI:58475" |
H | ||||||||
| BINDING | 71 | 71 | /ligand="5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide" /ligand_id="ChEBI:CHEBI:58475" |
[ST] | ||||||||
| BINDING | 232 | 232 | /ligand="5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide" /ligand_id="ChEBI:CHEBI:58475" |
N | ||||||||
Additional information
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| Size range | 330-377 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |