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| HAMAP annotation rule MF_01200 |
| Accession | MF_01200 |
| Dates | 15-JAN-2002 (Created) 31-OCT-2011 (Last updated, Version 26) |
| Name | OMPdecase_type1 |
| Scope | Bacteria Archaea |
case <OC:Bacteria>
| Triggered by |
end case
case <OC:Archaea>
| Triggered by |
end case
| Identifier |
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| Protein name |
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| Gene name |
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| FUNCTION | Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity). |
| CATALYTIC ACTIVITY | Orotidine 5'-phosphate = UMP + CO(2). |
| PATHWAY | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate; step 2/2. |
| SUBUNIT | Homodimer (By similarity). |
| SIMILARITY | Belongs to the OMP decarboxylase family. Type 1 subfamily. |
GO:0004590; Molecular function: orotidine-5'-phosphate decarboxylase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
case <OC:Bacteria>
| From: PYRF_ECOLI (P08244) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 71 | 80 | Substrate binding (By similarity) | D-x-K-x-x-D-x-x-x-x | ||||||||
| ACT_SITE | 73 | 73 | Proton donor (By similarity) | K | ||||||||
| BINDING | 22 | 22 | Substrate (By similarity) | D | ||||||||
| BINDING | 44 | 44 | Substrate (By similarity) | K | ||||||||
| BINDING | 131 | 131 | Substrate (By similarity) | T | ||||||||
| BINDING | 192 | 192 | Substrate (By similarity) | R | ||||||||
| BINDING | 201 | 201 | Substrate (By similarity) | Q | ||||||||
| BINDING (Optional) | 221 | 221 | Substrate; via amide nitrogen (By similarity) | G | ||||||||
| BINDING | 222 | 222 | Substrate (By similarity) | R | ||||||||
end case
case <OC:Archaea>
| From: PYRF_METTH (O26232) | ||||||||||||
| REGION | 70 | 79 | Substrate binding (By similarity) | D-x-K-x-x-D-x-x-x-x | ||||||||
| REGION | 180 | 190 | Substrate binding (By similarity) | |||||||||
| ACT_SITE | 72 | 72 | Proton donor (By similarity) | K | ||||||||
| BINDING | 20 | 20 | Substrate (By similarity) | D | ||||||||
| BINDING | 42 | 42 | Substrate (By similarity) | K | ||||||||
| BINDING | 127 | 127 | Substrate (By similarity) | S | ||||||||
| BINDING | 202 | 202 | Substrate; via amide nitrogen (By similarity) | G | ||||||||
| BINDING | 203 | 203 | Substrate (By similarity) | R | ||||||||
end case
case <OC:Bacteria>
| Size range: | 224-279 amino acids |
end case
case <OC:Archaea>
| Size range: | 208-244 amino acids |
end case
| Related Rules: | MF_01215 (PYRF) |
| Templates: | P25971 (PYRF_BACSU); P08244 (PYRF_ECOLI); Q59654 (PYRF_PSEAE); P07691 (PYRF_SALTY); O26232 (PYRF_METTH); O74110 (PYRF_THEAC); O58462 (PYRF_PYRHO); Q9WYG7 (PYRF_THEMA): [Recover all] |
| Fusion: | Nter: None; Cter: MF_01208 (pyrE) |
| Comments: | Divergent THEMA; sequence not included in alignment and not taken into account in size range |