AC   MF_01201;
DC   Protein; auto
TR   HAMAP; MF_01201; -; 1; level=0
XX
Names: Ala_racemase
XX
ID   ALR
DE   RecName: Full=Alanine racemase;
DE            EC=5.1.1.1;
XX
CC   -!- FUNCTION: Catalyzes the interconversion of L-alanine and D-alanine. May
CC       also act on other amino acids.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-alanine = D-alanine; Xref=Rhea:RHEA:20249,
CC         ChEBI:CHEBI:57416, ChEBI:CHEBI:57972; EC=5.1.1.1;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- PATHWAY: Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine
CC       from L-alanine: step 1/1.
CC   -!- SIMILARITY: Belongs to the alanine racemase family.
XX
DR   Pfam; PF00842; Ala_racemase_C; 1; trigger=no
DR   Pfam; PF01168; Ala_racemase_N; 1; trigger=no
DR   PRINTS; PR00992; ALARACEMASE; 1; trigger=no
DR   NCBIfam; TIGR00492; alr; 1; trigger=no
DR   PROSITE; PS00395; ALANINE_RACEMASE; 1; trigger=no
XX
KW   Isomerase
KW   Pyridoxal phosphate
XX
GO   GO:0008784; F:alanine racemase activity
GO   GO:0030170; F:pyridoxal phosphate binding
GO   GO:0006522; P:alanine metabolic process
XX
FT   From: ALR_GEOSE (P10724)
FT   ACT_SITE        39
FT                   /note="Proton acceptor; specific for D-alanine"
FT   Condition: K
FT   ACT_SITE        265
FT                   /note="Proton acceptor; specific for L-alanine"
FT   Condition: Y
FT   BINDING         136
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         312
FT                   /ligand="substrate"
FT   Optional; Condition: M
FT   MOD_RES         39
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
XX
Size: 300-470;
Related: None;
Template: P10724; Q9RER4; Q9S5V6; P10725; P0A6B4; P29012; O30746; Q9FCV2; G2K4Q7; Q9L888; P94967; P9WQA9; Q9HUN4; Q9HTQ2; P33162; Q9RAE7; P0A1A3; P06191; Q932V0; Q93HP9;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in AGRFC, BACSU, CLOAB, ECO57, ECOLI, OCEIH, PSEAE, RHILO, SALTI,
 SALTY, STAAM, STAAN, STAAU, VIBCH, YERPE
Plasmid: in RHILO
Comments: Annotated as alanine racemase, but could use other substrates in some organisms.
 In addition, it is not possible to automatically make a distinction between alr and dadX
 (or dadB) genes, but if these two genes are found in a genome, note that
 the catabolic alanine racemase dadX (which only exists in several species)
 is part of the dad operon (i.e. must be close to dadA gene).
XX
# Revision 1.41 2023/06/01
//