HAMAP

Accession	MF_01225
Dates	13-SEP-2002 (Created) 9-DEC-2011 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_01225_B; [distribution of match scores in UniProtKB];[seed alignment for MF_01225_B]

Predictors

HAMAP; MF_01225_A; [distribution of match scores in UniProtKB];[seed alignment for MF_01225_A]

Names

MoaA

Identifier

MOAA

Protein name

RecName: Full=Molybdenum cofactor biosynthesis protein A;

Protein name

RecName: Full=Probable molybdenum cofactor biosynthesis protein A;

Gene name

moaA

FUNCTION: Together with MoaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z (By similarity).

COFACTOR: Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate (By similarity).

PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.

SUBUNIT: Monomer and homodimer (By similarity).

SIMILARITY: Belongs to the radical SAM superfamily. MoaA family.

PROSITE	PS01305; MOAA_NIFB_PQQE; 1;
Pfam	PF06463; Mob_synth_C; 1; PF04055; Radical_SAM; 1;
TIGRFAMs	TIGR02666; MoaA; 1;

4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Molybdenum cofactor biosynthesis, Nucleotide-binding, S-adenosyl-L-methionine.

GO:0006777; Biological process: Mo-molybdopterin cofactor biosynthetic process.

From: MOAA_STAAN (P65388)
Key		From		To		Description		Condition		FTGroup
REGION		266		268		GTP binding (By similarity)		[RK]-x-R
METAL		24		24		Iron-sulfur 1 (4Fe-4S-S-AdoMet) (By similarity)		C
METAL		28		28		Iron-sulfur 1 (4Fe-4S-S-AdoMet) (By similarity)		C
METAL		31		31		Iron-sulfur 1 (4Fe-4S-S-AdoMet) (By similarity)		C
METAL		261		261		Iron-sulfur 2 (4Fe-4S-substrate) (By similarity)		C
METAL		264		264		Iron-sulfur 2 (4Fe-4S-substrate) (By similarity)		C
METAL		278		278		Iron-sulfur 2 (4Fe-4S-substrate) (By similarity)		C
BINDING		17		17		GTP (By similarity)		R
BINDING		30		30		S-adenosyl-L-methionine (By similarity)		Y
BINDING		71		71		GTP (By similarity)		R
BINDING		75		75		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)		G
BINDING		102		102		GTP (By similarity)		[TS]
BINDING		126		126		S-adenosyl-L-methionine (By similarity)		S
BINDING		163		163		GTP (By similarity)		K
BINDING		197		197		S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen (By similarity)		M

From: MOAA_PYRAB (Q9V2G2)
Key		From		To		Description		Condition		FTGroup
REGION		255		257		GTP binding (By similarity)		R-x-R
METAL		21		21		Iron-sulfur 1 (4Fe-4S-S-AdoMet) (By similarity)		C
METAL		25		25		Iron-sulfur 1 (4Fe-4S-S-AdoMet) (By similarity)		C
METAL		28		28		Iron-sulfur 1 (4Fe-4S-S-AdoMet) (By similarity)		C
METAL		250		250		Iron-sulfur 2 (4Fe-4S-substrate) (By similarity)		C
METAL		253		253		Iron-sulfur 2 (4Fe-4S-substrate) (By similarity)		C
METAL		267		267		Iron-sulfur 2 (4Fe-4S-substrate) (By similarity)		C
BINDING		14		14		GTP (By similarity)		R
BINDING (Optional)		27		27		S-adenosyl-L-methionine (By similarity)		Y
BINDING		61		61		GTP (By similarity)		[KR]
BINDING		65		65		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)		G
BINDING		90		90		GTP (By similarity)		T
BINDING		114		114		S-adenosyl-L-methionine (By similarity)		S
BINDING		150		150		GTP (By similarity)		K
BINDING (Optional)		189		189		S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen (By similarity)		M

Size range:

318-378 amino acids

Size range:

296-357 amino acids

Related UniRules:	None
Template:	P65388 (MOAA_STAAN); Q44118 (MOAA_ARTNI); P30745 (MOAA_ECOLI); Q9X5W3 (MOAA_RHOCA): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in MYCTU, PSEAE
Plasmid encoded:	in ARTNI