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| HAMAP annotation rule: MF_01259 |
| Accession |
MF_01259 |
| Dates |
21-APR-2005 (Created) 24-SEP-2010 (Last updated, Version 11) |
| Protein name |
| RecName: |
Full=F420-0:gamma-glutamyl ligase; EC=6.3.2.-; |
|
FUNCTION: Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives (By similarity).
CATALYTIC ACTIVITY: GTP + F420-0 + n L-glutamate = GDP + phosphate + F420-n.
COFACTOR: Divalent cation. The ion could be magnesium (By similarity).
COFACTOR: Monovalent cation. The ion could be potassium (By similarity).
PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
SIMILARITY: In the N-terminal section; belongs to the CofE family.
GO:0016881; Molecular function: acid-amino acid ligase activity.
GO:0009108; Biological process: coenzyme biosynthetic process.
| From: COFE_MYCBO (Q7TWV3) |
| Key |
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From |
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To |
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Description |
|
Condition |
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FTGroup |
| REGION |
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Nter |
|
244 |
|
F420-0:gamma-glutamyl ligase |
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|
|
|
| REGION |
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245 |
|
Cter |
|
Unknown |
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|
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| Size range: |
423-457 amino acids |
| Related UniRules: |
MF_01258 (COFE) |
| Template: |
Q7TWV3 (COFE_MYCBO) |
| Scope: |
Bacteria; Mycobacterium
Bacteria; Nocardia
Bacteria; Streptomyces |
| Fusion: |
Nter: None; Cter: None |
| Duplicate: |
None |
| Plasmid encoded: |
None |
| Comments: |
CofE homologs are found in the genomes of all organisms currently known to produce coenzyme F420. These include not only the methanogenic archaea but also nonmethanogenic archaea such as Halobacteria and Archaeoglobus (see MF_01258), as well as some eubacteria such as Streptomyces, Mycobacterium, Nocardia, and Thermobifida. |
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