AC   MF_01274;
DC   Protein; auto
TR   HAMAP; MF_01274; -; 1; level=0
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Names: Pantothen_kinase_3
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ID   COAX
DE   RecName: Full=Type III pantothenate kinase;
DE            EC=2.7.1.33;
DE   AltName: Full=PanK-III;
DE   AltName: Full=Pantothenic acid kinase;
GN   Name=coaX;
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CC   -!- FUNCTION: Catalyzes the phosphorylation of pantothenate (Pan), the
CC       first step in CoA biosynthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP +
CC         H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216;
CC         EC=2.7.1.33;
CC   -!- COFACTOR:
CC       Name=NH4(+); Xref=ChEBI:CHEBI:28938;
CC       Name=K(+); Xref=ChEBI:CHEBI:29103;
CC       Note=A monovalent cation. Ammonium or potassium.;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 1/5.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the type III pantothenate kinase family.
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DR   Pfam; PF03309; Pan_kinase; 1; trigger=no
DR   NCBIfam; TIGR00671; Baf; 1; trigger=no
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KW   Cytoplasm
KW   ATP-binding
KW   Coenzyme A biosynthesis
KW   Kinase
case <FT:4>
KW   Metal-binding
end case
KW   Nucleotide-binding
KW   Transferase
KW   Potassium
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GO   GO:0005524; F:ATP binding
GO   GO:0004594; F:pantothenate kinase activity
case <FT:4>
GO   GO:0043169; F:cation binding
end case
GO   GO:0015937; P:coenzyme A biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   From: COAX_PSEAE (Q9HWC1)
FT   BINDING         6..13
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   BINDING         99..102
FT                   /ligand="substrate"
FT   Condition: G-x-D-x
FT   ACT_SITE        101
FT                   /note="Proton acceptor"
FT   Condition: D
FT   BINDING         121
FT                   /ligand="K(+)"
FT                   /ligand_id="ChEBI:CHEBI:29103"
FT   Optional; Condition: D
FT   BINDING         92
FT                   /ligand="substrate"
FT   Optional; Condition: [YF]
FT   BINDING         124
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [TS]
FT   BINDING         180
FT                   /ligand="substrate"
FT   Optional; Condition: [TS]
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Size: 205-295;
Related: None;
Template: Q9HWC1; P37564; O25533; Q9WZY5;
Scope:
 Bacteria
Fusion:
 Nter: <birA>
 Cter: None
Duplicate: in FRAT1, FRATH, FRATO, FRATT, SYMTH
Plasmid: None
Comments: There are three distinct types of pantothenate kinase, as differenciated
 by primary sequence analysis and biochemical properties: type I (MF_00215),
 type II (MF_01273) and type III (MF_01274).
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# Revision 1.24 2023/06/01
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