AC   MF_01467;
DC   Protein; auto
TR   HAMAP; MF_01467; -; 1; level=0
XX
Names: Hypx_phosphoribosyltr
XX
case not <OC:Halobacteria>
ID   HPRT
DE   RecName: Full=Hypoxanthine/guanine phosphoribosyltransferase;
DE            Short=HGPRTase;
DE            EC=2.4.2.8;
GN   Name=hpt;
else case <OC:Halobacteria>
ID   HPRL
DE   RecName: Full=HGPRTase-like protein;
DE            EC=2.4.2.-;
end case
XX
case not <OC:Halobacteria>
CC   -!- FUNCTION: Catalyzes a salvage reaction resulting in the formation of
CC       IMP that is energically less costly than de novo synthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         hypoxanthine; Xref=Rhea:RHEA:17973, ChEBI:CHEBI:17368,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58053; EC=2.4.2.8;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         guanine; Xref=Rhea:RHEA:25424, ChEBI:CHEBI:16235, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58017, ChEBI:CHEBI:58115;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from hypoxanthine: step 1/1.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
else case <OC:Halobacteria>
CC   -!- FUNCTION: May catalyze a purine salvage reaction, the substrate is
CC       unknown.
end case
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. Archaeal HPRT subfamily.
XX
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1; trigger=no
DR   Pfam; PF00156; Pribosyltran; 1; trigger=no
XX
case not <OC:Halobacteria>
KW   Cytoplasm
KW   Glycosyltransferase
end case
KW   Purine salvage
KW   Transferase
XX
case not <OC:Halobacteria>
GO   GO:0004422; F:hypoxanthine phosphoribosyltransferase activity
GO   GO:0043103; P:hypoxanthine salvage
GO   GO:0005737; C:cytoplasm
end case
XX
FT   None
XX
Size: 181-196;
Related: None;
Template: O33174;
Scope:
 Archaea; Euryarchaeota
Fusion:
 Nter: None
 Cter: None
Duplicate: in HALJB, HALMA, HALTV, HALVD, HALWC, HALWD, NATMM
Plasmid: None
Comments: Halobacteria are known to have both hypoxanthine/guanine and
 adenine phosphoribosyltransferase activities; therefore we do not know
 what is the substrate for this enzyme is in Halobacteria.
XX
# Revision 1.5 2019/11/19
//