AC   MF_01511;
DC   Protein; auto
TR   HAMAP; MF_01511; -; 1; level=0
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Names: GMP_reduct_type2
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ID   GUAC
DE   RecName: Full=GMP reductase;
DE            EC=1.7.1.7;
DE   AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
DE            Short=Guanosine monophosphate reductase;
GN   Name=guaC;
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CC   -!- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP
CC       to IMP. It functions in the conversion of nucleobase, nucleoside and
CC       nucleotide derivatives of G to A nucleotides, and in maintaining the
CC       intracellular balance of A and G nucleotides.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH;
CC         Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115,
CC         ChEBI:CHEBI:58349; EC=1.7.1.7;
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
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DR   Pfam; PF00478; IMPDH; 1; trigger=no
DR   NCBIfam; TIGR01306; GMP_reduct_2; 1; trigger=no
DR   PROSITE; PS00487; IMP_DH_GMP_RED; 1; trigger=no
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KW   Oxidoreductase
KW   NADP
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GO   GO:0003920; F:GMP reductase activity
GO   GO:0006163; P:purine nucleotide metabolic process
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FT   From: GUAC_BACSU (O05269)
FT   BINDING         204..227
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   ACT_SITE        175
FT                   /note="Thioimidate intermediate"
FT   Condition: C
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Size: 316-330;
Related: None;
Template: O05269;
Scope:
 Bacteria; Bacillota
 Bacteria; Betaproteobacteria
 Bacteria; Campylobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.19 2023/06/01
//