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HAMAP annotation rule: MF_01585
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General rule information

Accession MF_01585
Dates 10-OCT-2007 (Created)
13-JUL-2010 (Last updated, Version 12)
Data class Protein
Predictors HAMAP; MF_01585; [distribution of match scores in UniProtKB];[seed alignment for MF_01585]
Names MFS_LplT


Propagated annotation

Identifier, protein and gene names
Identifier LPLT
Protein name
RecName: Full=Lysophospholipid transporter lplT;
Gene name lplT
Comments
FUNCTION: Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell (By similarity).

case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case

SIMILARITY: Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
Cross-references
PROSITE PS50850; MFS; 1;
Pfam PF07690; MFS_1; 1;
case not <OC:Escherichia> and not <OC:Shigella>
General Transmembrane; -; 11-12; trigger=Yes;
end case

Keywords
Cell membrane.

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case

Lipid transport, Membrane, Transmembrane, Transport, Transmembrane helix.
Gene Ontology
GO:0005319; Molecular function: lipid transporter activity.
GO:0006869; Biological process: lipid transport.
GO:0005886; Cellular component: plasma membrane.
Features

case <OC:Escherichia> or <OC:Shigella>
From: LPLT_ECOLI (P39196)
Key     From     To       Description   Condition   FTGroup
TOPO_DOM     Nter     17       Periplasmic (Potential)      
TRANSMEM     18     38       Helical; (Potential)      
TOPO_DOM     39     52       Cytoplasmic (Potential)      
TRANSMEM     53     73       Helical; (Potential)      
TOPO_DOM     74     90       Periplasmic (Potential)      
TRANSMEM     91     111       Helical; (Potential)      
TOPO_DOM     112     144       Cytoplasmic (Potential)      
TRANSMEM     145     165       Helical; (Potential)      
TOPO_DOM     166     166       Periplasmic (Potential)      
TRANSMEM     167     187       Helical; (Potential)      
TOPO_DOM     188     226       Cytoplasmic (Potential)      
TRANSMEM     227     247       Helical; (Potential)      
TOPO_DOM     248     256       Periplasmic (Potential)      
TRANSMEM     257     277       Helical; (Potential)      
TOPO_DOM     278     280       Cytoplasmic (Potential)      
TRANSMEM     281     301       Helical; (Potential)      
TOPO_DOM     302     304       Periplasmic (Potential)      
TRANSMEM     305     325       Helical; (Potential)      
TOPO_DOM     326     343       Cytoplasmic (Potential)      
TRANSMEM     344     364       Helical; (Potential)      
TOPO_DOM     365     366       Periplasmic (Potential)      
TRANSMEM     367     387       Helical; (Potential)      
TOPO_DOM     388     Cter       Cytoplasmic (Potential)      
end case



Additional information

Size range: 396-407 amino acids
Related UniRules: None
Template: P39196 (LPLT_ECOLI)
Scope: Bacteria; Enterobacteriaceae
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences