AC   MF_01611;
DC   Protein; auto
TR   HAMAP; MF_01611; -; 1; level=0
XX
Names: FO_synth_sub1
XX
ID   COFG
DE   RecName: Full=7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase;
DE            EC=4.3.1.32;
DE   AltName: Full=FO synthase subunit 1;
GN   Name=cofG;
XX
CC   -!- FUNCTION: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-
CC       hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-
CC       ribitylimino)-5,6-dihydrouracil.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-
CC         dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-
CC         didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine +
CC         NH4(+); Xref=Rhea:RHEA:55204, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319,
CC         ChEBI:CHEBI:28938, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:59904, ChEBI:CHEBI:85936; EC=4.3.1.32;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.;
end case
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F0 biosynthesis.
CC   -!- SUBUNIT: The FO synthase complex consists of two subunits, CofG and
CC       CofH.
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. CofG family.
XX
DR   Pfam; PF04055; Radical_SAM; 1; trigger=no
DR   NCBIfam; TIGR03550; F420_cofG; 1; trigger=no
XX
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
KW   S-adenosyl-L-methionine
end case
KW   Lyase
XX
case <FTGroup:1>
GO   GO:0005506; F:iron ion binding
end case
GO   GO:0016841; F:ammonia-lyase activity
XX
FT   From: COFG_METJA (Q57888)
FT   BINDING         49
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
FT   BINDING         53
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
FT   BINDING         56
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
XX
Size: 313-380;
Related: None;
Template: Q57888;
Scope:
 Bacteria; Cyanobacteriota
 Archaea; Euryarchaeota
Fusion:
 Nter: None
 Cter: MF_01612 (cofH)
Duplicate: None
Plasmid: None
Comments: Euryarchaeota, cyanobacteria and actinomycetes are known to produce coenzyme FO.
 Euryarchaeota and actinomycetes use it to synthesize coenzyme F420, whereas cyanobacteria
 use it for FO-dependent DNA photolyases.
 In actinomycetes, the two subunits cofG and cofH are fused, and are called fbiC.
 Possible wrong starts.
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# Revision 1.26 2023/06/01
//