AC   MF_01651;
DC   Protein; auto
TR   HAMAP; MF_01651; -; 1; level=0
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Names: HcaD
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ID   HCAD
DE   RecName: Full=3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component;
DE            EC=1.18.1.3;
GN   Name=hcaD;
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CC   -!- FUNCTION: Part of the multicomponent 3-phenylpropionate dioxygenase,
CC       that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into
CC       3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-
CC       dihydrodiol (CI-dihydrodiol), respectively.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2
CC         oxidized [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:16521, Rhea:RHEA-
CC         COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.18.1.3;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.
CC   -!- SUBUNIT: This dioxygenase system consists of four proteins: the two
CC       subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin
CC       (HcaC) and a ferredoxin reductase (HcaD).
CC   -!- SIMILARITY: Belongs to the bacterial ring-hydroxylating dioxygenase
CC       ferredoxin reductase family.
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DR   Pfam; PF00070; Pyr_redox; 1; trigger=no
DR   Pfam; PF07992; Pyr_redox_2; 1; trigger=no
DR   PRINTS; PR00368; FADPNR; 1; trigger=no
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KW   Aromatic hydrocarbons catabolism
KW   FAD
KW   Flavoprotein
KW   NAD
KW   Oxidoreductase
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GO   GO:0008695; F:3-phenylpropionate dioxygenase activity
GO   GO:0019439; P:aromatic compound catabolic process
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FT   From: HCAD_ECOLI (P77650)
FT   BINDING         5..36
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   BINDING         146..174
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
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Size: 394-410;
Related: None;
Template: P77650;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: in ECO24
Plasmid: None
Comments: None
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# Revision 1.18 2022/11/19
//